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When Is a New Prediction Marker Useful?

When Is a New Prediction Marker Useful? EDITORIAL A Consideration of Lipoprotein-Associated Phospholipase A and C-Reactive Protein for Stroke Risk SCHEMIC STROKE IS A COMMON AND OFTEN DEV- justed for the major traditional risk factors. In the high- astating condition that can cause significant dis- est tertile, CRP level was associated with higher stroke ability or death. In light of the dire conse- risk by about 2-fold, although confidence intervals were quences of a completed stroke, the search for wide. For Lp-PLA levels in the top tertile, with adjust- I improved predictive models and new markers ment for traditional risk factors and CRP, stroke risk was to identify patients at heightened risk is well justified. higher by about 2-fold as well. Thus, Lp-PLA level was Such high-risk patients would be candidates for proven a moderately strong stroke risk predictor, and its asso- stroke-prevention therapies including aspirin, antihy- ciation with stroke in this study was statistically inde- pertensive medications, and HMG-CoA (3-hydroxy-3- pendent of traditional risk factors as well as the inflam- methylglutaryl coenzyme A) reductase inhibitors. matory marker CRP. In unadjusted analyses, apparently Over the past several decades, multivariable models healthy middle-aged people with high levels of both CRP have been developed for prediction of coronary http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

When Is a New Prediction Marker Useful?

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Publisher
American Medical Association
Copyright
Copyright 2005 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinte.165.21.2454
pmid
16314539
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL A Consideration of Lipoprotein-Associated Phospholipase A and C-Reactive Protein for Stroke Risk SCHEMIC STROKE IS A COMMON AND OFTEN DEV- justed for the major traditional risk factors. In the high- astating condition that can cause significant dis- est tertile, CRP level was associated with higher stroke ability or death. In light of the dire conse- risk by about 2-fold, although confidence intervals were quences of a completed stroke, the search for wide. For Lp-PLA levels in the top tertile, with adjust- I improved predictive models and new markers ment for traditional risk factors and CRP, stroke risk was to identify patients at heightened risk is well justified. higher by about 2-fold as well. Thus, Lp-PLA level was Such high-risk patients would be candidates for proven a moderately strong stroke risk predictor, and its asso- stroke-prevention therapies including aspirin, antihy- ciation with stroke in this study was statistically inde- pertensive medications, and HMG-CoA (3-hydroxy-3- pendent of traditional risk factors as well as the inflam- methylglutaryl coenzyme A) reductase inhibitors. matory marker CRP. In unadjusted analyses, apparently Over the past several decades, multivariable models healthy middle-aged people with high levels of both CRP have been developed for prediction of coronary

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Nov 28, 2005

References