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What Is the Evidence Supporting Chemotherapy for Intraocular Retinoblastoma?

What Is the Evidence Supporting Chemotherapy for Intraocular Retinoblastoma? Abstract I read with interest the article by Gallie et al1 in the November 1996 issue of the Archives regarding the use of chemotherapy in eyes with intraocular retinoblastoma. Gallie et al describe a series of 40 eyes treated with focal therapy and chemotherapy—eyes that "conventionally should be enucleated or receive radiotherapy."1 However, 16 (40%) of these 40 eyes contained tumors that measured 10 disc diameters or less (Reese-Ellsworth [RE] classification I-II), which in other institutions would have been treated with focal treatment modalities alone (laser therapy, cryotherapy, and plaque brachytherapy) if the macula was uninvolved. These patients would not have required external beam radiotherapy [EBR], much less enucleation. This discrepancy could be due to the unavailability of plaque brachytherapy in their institution, but this is not mentioned in the text; it is also not explained why the authors did not make this focal modality available to their patients References 1. Gallie BL, Budning A, DeBoer G, et al. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy . Arch Ophthalmol . 1996;114:1321-1328.Crossref 2. Murphree AL, Villabianca JG, Deegan WF III, et al. Chemotherapy plus local treatment in the management of intraocular retinoblastoma . Arch Ophthalmol . 1996;114:1348-1356.Crossref 3. Hernandez JC, Brady LW. Conservative treatment of retinoblastoma: the use of plaque brachytherapy . Am J Clin Oncol . 1993;16:397-401.Crossref 4. Eng C, Li FP, Abramson DH, et al. Mortality from second tumors among long-term survivors of retinoblastoma . J Nati Cancer Inst . 1993;85:1121-1128.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

What Is the Evidence Supporting Chemotherapy for Intraocular Retinoblastoma?

Archives of Ophthalmology , Volume 115 (12) – Dec 1, 1997

What Is the Evidence Supporting Chemotherapy for Intraocular Retinoblastoma?

Abstract

Abstract I read with interest the article by Gallie et al1 in the November 1996 issue of the Archives regarding the use of chemotherapy in eyes with intraocular retinoblastoma. Gallie et al describe a series of 40 eyes treated with focal therapy and chemotherapy—eyes that "conventionally should be enucleated or receive radiotherapy."1 However, 16 (40%) of these 40 eyes contained tumors that measured 10 disc diameters or less (Reese-Ellsworth [RE] classification I-II), which in...
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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1997.01100160774025
Publisher site
See Article on Publisher Site

Abstract

Abstract I read with interest the article by Gallie et al1 in the November 1996 issue of the Archives regarding the use of chemotherapy in eyes with intraocular retinoblastoma. Gallie et al describe a series of 40 eyes treated with focal therapy and chemotherapy—eyes that "conventionally should be enucleated or receive radiotherapy."1 However, 16 (40%) of these 40 eyes contained tumors that measured 10 disc diameters or less (Reese-Ellsworth [RE] classification I-II), which in other institutions would have been treated with focal treatment modalities alone (laser therapy, cryotherapy, and plaque brachytherapy) if the macula was uninvolved. These patients would not have required external beam radiotherapy [EBR], much less enucleation. This discrepancy could be due to the unavailability of plaque brachytherapy in their institution, but this is not mentioned in the text; it is also not explained why the authors did not make this focal modality available to their patients References 1. Gallie BL, Budning A, DeBoer G, et al. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy . Arch Ophthalmol . 1996;114:1321-1328.Crossref 2. Murphree AL, Villabianca JG, Deegan WF III, et al. Chemotherapy plus local treatment in the management of intraocular retinoblastoma . Arch Ophthalmol . 1996;114:1348-1356.Crossref 3. Hernandez JC, Brady LW. Conservative treatment of retinoblastoma: the use of plaque brachytherapy . Am J Clin Oncol . 1993;16:397-401.Crossref 4. Eng C, Li FP, Abramson DH, et al. Mortality from second tumors among long-term survivors of retinoblastoma . J Nati Cancer Inst . 1993;85:1121-1128.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1997

References