Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Werner Syndrome Disputed

Werner Syndrome Disputed This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor. —In the July issue of the Archives (90:53-56, 1973), Drs. Bullock and Howard reported a case of Werner syndrome. I find the diagnosis unconvincing because of the number of atypical features, which are as follows: Age of presentation. Cataract is commonly present by the age of 20, and by the age of 30 causes severe visual impairment. In more than 100 reported cases, only about 30 patients were over the age of 40 at diagnosis, mostly either relatives of patients with the syndrome who did not show the full picture, or patients in whom the diagnosis was missed at earlier examinations. Looseness of paper-like skin around the knees and ankles may be seen early in the disease, but tautness of skin over the face and extremities and ulceration are the characteristic features later. It is unusual for these patients to father children, since hypogonadism http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Werner Syndrome Disputed

Archives of Ophthalmology , Volume 91 (4) – Apr 1, 1974

Werner Syndrome Disputed

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor. —In the July issue of the Archives (90:53-56, 1973), Drs. Bullock and Howard reported a case of Werner syndrome. I find the diagnosis unconvincing because of the number of atypical features, which are as follows: Age of presentation. Cataract is commonly present by the age of 20, and by the age of 30 causes severe visual...
Loading next page...
 
/lp/american-medical-association/werner-syndrome-disputed-h89gEUiyLy
Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1974.03900060342020
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor. —In the July issue of the Archives (90:53-56, 1973), Drs. Bullock and Howard reported a case of Werner syndrome. I find the diagnosis unconvincing because of the number of atypical features, which are as follows: Age of presentation. Cataract is commonly present by the age of 20, and by the age of 30 causes severe visual impairment. In more than 100 reported cases, only about 30 patients were over the age of 40 at diagnosis, mostly either relatives of patients with the syndrome who did not show the full picture, or patients in whom the diagnosis was missed at earlier examinations. Looseness of paper-like skin around the knees and ankles may be seen early in the disease, but tautness of skin over the face and extremities and ulceration are the characteristic features later. It is unusual for these patients to father children, since hypogonadism

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1974

There are no references for this article.