Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

WERNER'S SYNDROME: Report of Two Cases

WERNER'S SYNDROME: Report of Two Cases Abstract WERNER1 described cataracts associated with scleroderma in four brothers and sisters. Since his publication in 1904, the syndrome to which his name has been attached has been considerably altered. Endocrine abnormalities, including hypogonadism, osteoporosis, and hyperglycemia have been added features, whereas one of the two original characteristics, the sclerotic tightening of the skin has proved not to be scleroderma. Contrary to early reports of cataracts developing in the second and third decades, Schott and Dann2 observed the onset in the fourth decade, also mentioning instances in which all characteristics of the syndrome were not present. They considered these as "forme fruste." It is therefore possible to diagnose Werner's syndrome by only one of the two original signs, if there are endocrine and skeletal findings. Franceschetti and Maeder3 defined Werner's syndrome as cataracts associated with scleroderma, and differentiated it from References 1. References 7 and 8. 2. Werner, C. W. O.: Über Katarakt in Verbindung mit Sklerodermie, Thesis, Kiel, Schmidt and Klauning, 1904. 3. Schott, J., and Dann, S.: Werner's Syndrome: Report of 2 Cases , New England J. Med. , 240:641-644, 1949.Crossref 4. Franceschetti, A., and Maeder, G.: Cataracte et affections cutanées de type póikilodermie (syndrome de Rothmund) et du type Sclérodermie (Syndrome de Werner) , Schweiz. Med Wchnschr. 79: 657-663, 1949. 5. Thannhauser, S. J.: Werner's Syndrome (Progeria of Adults) and Rothmund's Syndrome: 2 Types of Closely Related Heredofamilial Atrophic Dermatoses with Juvenile Cataracts and Endocrine Features; Critical Study with 5 New Cases , Ann. Int. Med. 23:559-626, 1945.Crossref 6. Weber, F. P.: Proc. Roy. Soc. Med. 29: 453-455 ( (Pt. I) ) 1936. 7. Rook, A., and Whimster, I.: Congenital Cutaneous Dystrophy (Thomson's Type) , Brit. J. Dermat. 61:197-205, 1949.Crossref 8. Oppenheimer, B. S., and Kugel, V. H.: Werner's Syndrome: Heredofamilial Disorders with Scleroderma, Bilateral Juvenile Cataract, Precocious Graying of the Hair and Endocrine Stigmatization , Tr. A. Am. Physicians 49:358-370, 1934. 9. Oppenheimer, B. S., and Kugel, V. H.: Werner's Syndrome: Report of First Necropsy and of Findings in New Case , Am. J. M. Sc. 202:629-642, 1941.Crossref 10. Winer, N. J.: The Hamilton-Schwartz Test and Hyperparathyroidism in Various Diseases , Am. J. M. Sc. 202:642-650, 1941.Crossref 11. Irwin, G. W., and Ward, P. B.: Werner's Syndrome, with a Report of 2 Cases , Am. J. Med. 15:266-271, 1953.Crossref 12. Reed, R.; Seville, R. H., and Tattersall, R. N.: Werner's Syndrome , Brit. J. Dermat. 65:165-176, 1953.Crossref 13. Sulzberger, M. B.: Dyshormonal Dermatoses (Werner's Syndrome) (Scleroderma, Poikiloderma, Bilateral Juvenile Cataract, Precocious Graying of the Hair, Pluriglandular Dysfunction), Case Presentation, New York Academy of Medicine, Section of Dermatology and Syphilis, Feb. 2, 1937 , Arch. Dermat. & Syph. 36:1256-1259, 1937. 14. Bloch, B., and Stauffer, H.: Skin Diseases of Endocrine Origin (Dyshormonal Dermatosis): Poikiloderma-like Changes in Connection with Underdevelopment of the Sexual Glands and Dystrophia Adiposogenitalis , Arch. Dermat. & Syph. , 19: 22-34, 1929. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

WERNER'S SYNDROME: Report of Two Cases

Loading next page...
 
/lp/american-medical-association/werner-s-syndrome-report-of-two-cases-RDABaX3QcH

References (9)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1955.01540260055012
Publisher site
See Article on Publisher Site

Abstract

Abstract WERNER1 described cataracts associated with scleroderma in four brothers and sisters. Since his publication in 1904, the syndrome to which his name has been attached has been considerably altered. Endocrine abnormalities, including hypogonadism, osteoporosis, and hyperglycemia have been added features, whereas one of the two original characteristics, the sclerotic tightening of the skin has proved not to be scleroderma. Contrary to early reports of cataracts developing in the second and third decades, Schott and Dann2 observed the onset in the fourth decade, also mentioning instances in which all characteristics of the syndrome were not present. They considered these as "forme fruste." It is therefore possible to diagnose Werner's syndrome by only one of the two original signs, if there are endocrine and skeletal findings. Franceschetti and Maeder3 defined Werner's syndrome as cataracts associated with scleroderma, and differentiated it from References 1. References 7 and 8. 2. Werner, C. W. O.: Über Katarakt in Verbindung mit Sklerodermie, Thesis, Kiel, Schmidt and Klauning, 1904. 3. Schott, J., and Dann, S.: Werner's Syndrome: Report of 2 Cases , New England J. Med. , 240:641-644, 1949.Crossref 4. Franceschetti, A., and Maeder, G.: Cataracte et affections cutanées de type póikilodermie (syndrome de Rothmund) et du type Sclérodermie (Syndrome de Werner) , Schweiz. Med Wchnschr. 79: 657-663, 1949. 5. Thannhauser, S. J.: Werner's Syndrome (Progeria of Adults) and Rothmund's Syndrome: 2 Types of Closely Related Heredofamilial Atrophic Dermatoses with Juvenile Cataracts and Endocrine Features; Critical Study with 5 New Cases , Ann. Int. Med. 23:559-626, 1945.Crossref 6. Weber, F. P.: Proc. Roy. Soc. Med. 29: 453-455 ( (Pt. I) ) 1936. 7. Rook, A., and Whimster, I.: Congenital Cutaneous Dystrophy (Thomson's Type) , Brit. J. Dermat. 61:197-205, 1949.Crossref 8. Oppenheimer, B. S., and Kugel, V. H.: Werner's Syndrome: Heredofamilial Disorders with Scleroderma, Bilateral Juvenile Cataract, Precocious Graying of the Hair and Endocrine Stigmatization , Tr. A. Am. Physicians 49:358-370, 1934. 9. Oppenheimer, B. S., and Kugel, V. H.: Werner's Syndrome: Report of First Necropsy and of Findings in New Case , Am. J. M. Sc. 202:629-642, 1941.Crossref 10. Winer, N. J.: The Hamilton-Schwartz Test and Hyperparathyroidism in Various Diseases , Am. J. M. Sc. 202:642-650, 1941.Crossref 11. Irwin, G. W., and Ward, P. B.: Werner's Syndrome, with a Report of 2 Cases , Am. J. Med. 15:266-271, 1953.Crossref 12. Reed, R.; Seville, R. H., and Tattersall, R. N.: Werner's Syndrome , Brit. J. Dermat. 65:165-176, 1953.Crossref 13. Sulzberger, M. B.: Dyshormonal Dermatoses (Werner's Syndrome) (Scleroderma, Poikiloderma, Bilateral Juvenile Cataract, Precocious Graying of the Hair, Pluriglandular Dysfunction), Case Presentation, New York Academy of Medicine, Section of Dermatology and Syphilis, Feb. 2, 1937 , Arch. Dermat. & Syph. 36:1256-1259, 1937. 14. Bloch, B., and Stauffer, H.: Skin Diseases of Endocrine Origin (Dyshormonal Dermatosis): Poikiloderma-like Changes in Connection with Underdevelopment of the Sexual Glands and Dystrophia Adiposogenitalis , Arch. Dermat. & Syph. , 19: 22-34, 1929.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1955

There are no references for this article.