Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Weight Gain at the Time of Menopause

Weight Gain at the Time of Menopause Abstract We studied prospectively the weight change and the effect of weight change on changes in coronary heart disease risk factors in a population-based sample of 485 middle-aged women. All women were studied first in 1983 to 1984, when they were premenopausal and aged 42 to 50 years, and then restudied in 1987. Women gained an average of 2.25 +-4.14.19 kg during this 3-year period; 20% of women gained 4.5 kg or more, and only 3% lost 4.5 kg or more. There were no significant differences in weight gain of women who remained premenopausal and those who had a natural menopause ( + 2.07 kg vs +11.35 kg). Weight gain was significantly associated with increases in blood pressure and levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, and fasting insulin. Weight gain is thus a common occurrence for women at the time of menopause and is related to the changes in coronary heart disease risk factors observed during this period. Efforts to lose weight or to prevent weight gain may help to mitigate the worsening in coronary heart disease risk factors in middle-aged women. (Arch Intern Med. 1991;151:97-102) References 1. Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk factor for coronary heart disease . N Engl J Med. 1989;321:641-646.Crossref 2. Hjortland MC, McNamara, Kannel WB. Some atherogenic concomitants of menopause: the Framingham Study . Am J Epidemiol. 1976;103:304-311. 3. Lindquist 0, Bengtsson C. Serum lipids, arterial blood pressure and body weight in relation to the menopause: results from a population study of women in Goteborg,Sweden. Scand J Clin Lab Invest. 1980;40:629-636.Crossref 4. Hamman RF, Bennett PH, Miller M. The effect of menopause on serum cholesterol in American (Pima) Indian women . Am J Epidemiol. 1975;102:164-169. 5. Matthews KA, Kelsey SF, Meilahn EN, Kuller LH, Wing RR. Education al attainment and behavioral and biological risk factors for coronary heart disease in middle aged women . Am J Epidemiol. 1989;129:1132-1144. 6. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determi nation of total serum cholesterol . Clin Chem. 1974;20:470-475. 7. Warnick GR, Albers JJ. A comprehensive evaluation of the heparinmanganese precipitation procedure for estimating high density lipoprotein cholesterol . J Lipid Res. 1978;19:65-76. 8. Gidz LI, Miller GJ, Burstein M, et al. Analyses of plasma high density lipoprotein subclasses by a precipitation procedure: correlations with prepara tive and analytical centrifugation . In: Lippel K, ed. Report of the High Density Lipoprotein Methodology Workshop, San Francisco, California, March 12, 13, and 14, 1979 . Bethesda, Md: Department of Health, Education, and Wel fare, Public Health Service, National Institutes of Health; 1979:328-342. NIH publication 79-1661. 9. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes . Clin Chem. 1973;19:476-482. 10. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentra tion of low-density lipoprotein cholesterol in plasma, without use of the prepar ative ultracentrifuge . Clin Chem. 1972;18:499-502. 11. Medoza SG, Zerpa A, Carrasco H, et al. Estradiol, testosterone, apolipo proteins, lipoprotein cholesterol, and lipolytic enzymes in men with premature myocardial infarction and angiographically assessed coronary occlusion . Ar tery. 1983;12:1-23. 12. Stein EA, DiPersio L, Pesce AJ, et al. Enzyme-linked immunoabsorbent assay of apolipoprotein A-II in plasma, with use of a monoclonal antibody . Clin Chem. 1986;32:967-971. 13. Herbert V, Lauk K-S, Gottlieb CW, Belcher SJ. Coated charcoal immu noassay of insulin . J Clin Endocrinol Metab. 1965;25:1375-1384.Crossref 14. Garrow JS. Zero-muddler for unprejudiced sphygmomanometry . Lan cet. 1963;2:1205. 15. Dischinger P, DuChene AG. Quality control aspects of blood pressure measurements in the Multiple Risk Factor Intervention Trial . Controlled Clin Trials. 1986;7( (suppl) ):137S-157S.Crossref 16. Paffenbarger RS Jr, Wing AL, Hyde RT. Physical activity as an index of heart attack risk in college alumni . Am J Epidemiol. 1978;108:161-175. 17. Adams CF. Nutritive Value of American Foods in Common Units. Washington,DC: Agricultural Research Service, Department of Agriculture; 1975. Agriculture handbook 456. 18. Nutrition Coordinating Center. Reference Food Table, Version 10. Min neapolis, Minn: University of Minnesota; 1984. 19. Haynes SG, Levine S, Scotch N, et al. The relationship of psychosocial factors to coronary heart disease in the Framingham study . Am J Epidemiol. 1978;107:362-383. 20. Beck AT, Beamesderfer A. Assessment of depression: the depression inventory . In: Pinchot P, ed. Psychological Measurements in Psychopharmacology . Basel, Switzerland: S Karger AG; 1974;7:151-169. 21. Spielberger CD, Johnson EH, Russell SF, et al. The experience and expression of anger . In: Chesney MA, Goldston SE, Rosenman RH, eds. Anger and Hostility in Behavioral Medicine . New York, NY: Hemisphere/McGraw-Hill International Book Co; 1985:3-19. 22. Utian WH. Effect of postmenopausal estrogen therapy on diastolic blood pressure and body weight . Maturitas. 1978;1:3-8.Crossref 23. Williamson DF, Kahn HS, Remington PL, Anda RF. The 10-year inci dence of overweight and major weight gain in US adults . Arch Intern Med. 1990;150:665-672.Crossref 24. Blackburn GL, Read JL. Benefits of reducing—revisited . Postgrad Med. 1984;60:13-18. 25. Follick MJ, Abrams DB, Smith TW, et al. Contrasting short- and long-term effects of weight loss on lipoprotein levels . Arch Intern Med. 1984;144:1571-1574.Crossref 26. Jacob RG, Wing R, Shapiro AP. The behavioral treatment of hyperten sion: long-term effects . Behav Ther. 1987;18:325-352.Crossref 27. Manson JE, Colditz GA, Stampeer MJ, et al. A prospective study of obesity and risk of coronary heart disease in women . N Engl J Med. 1990;322:882-889.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Loading next page...
 
/lp/american-medical-association/weight-gain-at-the-time-of-menopause-0HPmZFQncp
Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1991.00400010111016
Publisher site
See Article on Publisher Site

Abstract

Abstract We studied prospectively the weight change and the effect of weight change on changes in coronary heart disease risk factors in a population-based sample of 485 middle-aged women. All women were studied first in 1983 to 1984, when they were premenopausal and aged 42 to 50 years, and then restudied in 1987. Women gained an average of 2.25 +-4.14.19 kg during this 3-year period; 20% of women gained 4.5 kg or more, and only 3% lost 4.5 kg or more. There were no significant differences in weight gain of women who remained premenopausal and those who had a natural menopause ( + 2.07 kg vs +11.35 kg). Weight gain was significantly associated with increases in blood pressure and levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, and fasting insulin. Weight gain is thus a common occurrence for women at the time of menopause and is related to the changes in coronary heart disease risk factors observed during this period. Efforts to lose weight or to prevent weight gain may help to mitigate the worsening in coronary heart disease risk factors in middle-aged women. (Arch Intern Med. 1991;151:97-102) References 1. Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk factor for coronary heart disease . N Engl J Med. 1989;321:641-646.Crossref 2. Hjortland MC, McNamara, Kannel WB. Some atherogenic concomitants of menopause: the Framingham Study . Am J Epidemiol. 1976;103:304-311. 3. Lindquist 0, Bengtsson C. Serum lipids, arterial blood pressure and body weight in relation to the menopause: results from a population study of women in Goteborg,Sweden. Scand J Clin Lab Invest. 1980;40:629-636.Crossref 4. Hamman RF, Bennett PH, Miller M. The effect of menopause on serum cholesterol in American (Pima) Indian women . Am J Epidemiol. 1975;102:164-169. 5. Matthews KA, Kelsey SF, Meilahn EN, Kuller LH, Wing RR. Education al attainment and behavioral and biological risk factors for coronary heart disease in middle aged women . Am J Epidemiol. 1989;129:1132-1144. 6. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determi nation of total serum cholesterol . Clin Chem. 1974;20:470-475. 7. Warnick GR, Albers JJ. A comprehensive evaluation of the heparinmanganese precipitation procedure for estimating high density lipoprotein cholesterol . J Lipid Res. 1978;19:65-76. 8. Gidz LI, Miller GJ, Burstein M, et al. Analyses of plasma high density lipoprotein subclasses by a precipitation procedure: correlations with prepara tive and analytical centrifugation . In: Lippel K, ed. Report of the High Density Lipoprotein Methodology Workshop, San Francisco, California, March 12, 13, and 14, 1979 . Bethesda, Md: Department of Health, Education, and Wel fare, Public Health Service, National Institutes of Health; 1979:328-342. NIH publication 79-1661. 9. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes . Clin Chem. 1973;19:476-482. 10. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentra tion of low-density lipoprotein cholesterol in plasma, without use of the prepar ative ultracentrifuge . Clin Chem. 1972;18:499-502. 11. Medoza SG, Zerpa A, Carrasco H, et al. Estradiol, testosterone, apolipo proteins, lipoprotein cholesterol, and lipolytic enzymes in men with premature myocardial infarction and angiographically assessed coronary occlusion . Ar tery. 1983;12:1-23. 12. Stein EA, DiPersio L, Pesce AJ, et al. Enzyme-linked immunoabsorbent assay of apolipoprotein A-II in plasma, with use of a monoclonal antibody . Clin Chem. 1986;32:967-971. 13. Herbert V, Lauk K-S, Gottlieb CW, Belcher SJ. Coated charcoal immu noassay of insulin . J Clin Endocrinol Metab. 1965;25:1375-1384.Crossref 14. Garrow JS. Zero-muddler for unprejudiced sphygmomanometry . Lan cet. 1963;2:1205. 15. Dischinger P, DuChene AG. Quality control aspects of blood pressure measurements in the Multiple Risk Factor Intervention Trial . Controlled Clin Trials. 1986;7( (suppl) ):137S-157S.Crossref 16. Paffenbarger RS Jr, Wing AL, Hyde RT. Physical activity as an index of heart attack risk in college alumni . Am J Epidemiol. 1978;108:161-175. 17. Adams CF. Nutritive Value of American Foods in Common Units. Washington,DC: Agricultural Research Service, Department of Agriculture; 1975. Agriculture handbook 456. 18. Nutrition Coordinating Center. Reference Food Table, Version 10. Min neapolis, Minn: University of Minnesota; 1984. 19. Haynes SG, Levine S, Scotch N, et al. The relationship of psychosocial factors to coronary heart disease in the Framingham study . Am J Epidemiol. 1978;107:362-383. 20. Beck AT, Beamesderfer A. Assessment of depression: the depression inventory . In: Pinchot P, ed. Psychological Measurements in Psychopharmacology . Basel, Switzerland: S Karger AG; 1974;7:151-169. 21. Spielberger CD, Johnson EH, Russell SF, et al. The experience and expression of anger . In: Chesney MA, Goldston SE, Rosenman RH, eds. Anger and Hostility in Behavioral Medicine . New York, NY: Hemisphere/McGraw-Hill International Book Co; 1985:3-19. 22. Utian WH. Effect of postmenopausal estrogen therapy on diastolic blood pressure and body weight . Maturitas. 1978;1:3-8.Crossref 23. Williamson DF, Kahn HS, Remington PL, Anda RF. The 10-year inci dence of overweight and major weight gain in US adults . Arch Intern Med. 1990;150:665-672.Crossref 24. Blackburn GL, Read JL. Benefits of reducing—revisited . Postgrad Med. 1984;60:13-18. 25. Follick MJ, Abrams DB, Smith TW, et al. Contrasting short- and long-term effects of weight loss on lipoprotein levels . Arch Intern Med. 1984;144:1571-1574.Crossref 26. Jacob RG, Wing R, Shapiro AP. The behavioral treatment of hyperten sion: long-term effects . Behav Ther. 1987;18:325-352.Crossref 27. Manson JE, Colditz GA, Stampeer MJ, et al. A prospective study of obesity and risk of coronary heart disease in women . N Engl J Med. 1990;322:882-889.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1991

References