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WATER METABOLISM IN WATER INTOXICATION

WATER METABOLISM IN WATER INTOXICATION HISTORY IN HIS classic study of the effects on mammals of the administration of excessive quantities of water, Rowntree1 stated that physiologists were apparently the first to notice the toxicity of fresh water for lower orders of life. In 1866 Bert2 ascribed the toxic effect of fresh water for the mullet to the difference in osmotic pressure between fresh water and sea water, the former causing the tissues to absorb water in excess. In 1904 Bullot3 proved the toxicity of distilled water for the fresh-water grammarus and also found that the addition of sodium chloride, sufficient to yield 0.000008-molar salt solution, was effective in overcoming the toxicity. In 1921 Miller and Williams4 studied the effect of excessive intake of water, clinically, on the blood pressure and nonprotein nitrogen in the blood of three patients with renal disease who were given 5 to 15 liters of water http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1952.02040090064006
Publisher site
See Article on Publisher Site

Abstract

HISTORY IN HIS classic study of the effects on mammals of the administration of excessive quantities of water, Rowntree1 stated that physiologists were apparently the first to notice the toxicity of fresh water for lower orders of life. In 1866 Bert2 ascribed the toxic effect of fresh water for the mullet to the difference in osmotic pressure between fresh water and sea water, the former causing the tissues to absorb water in excess. In 1904 Bullot3 proved the toxicity of distilled water for the fresh-water grammarus and also found that the addition of sodium chloride, sufficient to yield 0.000008-molar salt solution, was effective in overcoming the toxicity. In 1921 Miller and Williams4 studied the effect of excessive intake of water, clinically, on the blood pressure and nonprotein nitrogen in the blood of three patients with renal disease who were given 5 to 15 liters of water

Journal

American journal of diseases of childrenAmerican Medical Association

Published: May 1, 1952

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