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Warthin's Tumor: Electron Microscopic Studies

Warthin's Tumor: Electron Microscopic Studies Abstract PAPILLARY cystadenoma lymphomatosum, a benign neoplasm of the human parotid gland, was first recognized in 1895 by Hildebrand1 and was accurately described in 1910 by Albrecht and Arzt.2 This tumor acquired its eponymic designation in 1929, when it was described in the American literature by Warthin.3 Warthin's tumor is thought to arise from salivary gland structures incorporated in lymph nodes adjacent to or embedded in the parotid gland.4,5 Azzopardi and Hou4 have demonstrated direct histological transition from normal ducts to tumor epithelium. Smith5 considers Warthin's tumor to be the result of metaplastic and neoplastic alteration of salivary gland ductal epithelium accompanied by an increase in lymphoid tissue. In the light microscope, Warthin's tumor is seen to be made up of blunt, papillomatous processes, which consist of masses of lymphoid cells covered by a layer of pseudostratified epithelium.6 These processes project into cystic spaces References 1. Hildebrand, O.: Uber angeborene epitheliale Cysten und Fisteln des Halses , Arch Klin Chir 49:167-192, 1895. 2. Albrecht, H., and Arzt, L.: Beiträge zur Frage der Gewebsverirrung: Papilläre Cystadenome in Lymphdrüsen , Z Path 4:47-69, 1910. 3. Warthin, A.S.: Papillary Cystadenoma Lymphomatosum: A Rare Teratoid of the Parotid Region , J Cancer Res 13:116-125, 1929. 4. Azzopardi, J.G., and Hou, L.T.: The Genesis of Adenolymphoma , J Path Bact 88:213-218, 1964.Crossref 5. Smith, J.F.: Classification of Major Salivary Gland Lesions , Arch Otolaryng 80:322-349, 1964.Crossref 6. Tandler, B., and Shipkey, F.H.: Ultrastructure of Warthin's Tumor: I. Mitochondria , J Ultrastruct Res 11:292-305, 1964.Crossref 7. Fisher, E.R., and Sharkey, D.A.: The Ultrastructure of Colonic Polyps and Cancer With Special Reference to the Epithelial Inclusion Bodies of Leuchtenberger , Cancer 15:160-170, 1962.Crossref 8. Ito, S.: The Enteric Surface Coat on Cat Intestinal Microvilli , J Cell Biol 27:475-491, 1965.Crossref 9. Fawcett, D.W.: Surface Specializations of Absorbing Cells , J Histochem Cytochem 13:75-91, 1965.Crossref 10. Azzopardi, J.G., and Smith, O.D.: Salivary Gland Tumors and Their Mucins , J Path Bact 77:131-140, 1959.Crossref 11. Balogh, K., Jr., and Roth, S.I.: Histochemical and Electron Microscopic Studies of Eosinophilic Granular Cells (Oncocytes) in Tumors of the Parotid Gland , Lab Invest 14:310-320, 1965. 12. McGavran, M.H.: The Ultrastructure of Papillary Cystadenoma Lymphomatosum of the Parotid Gland , Virchow Arch Path Anat 338:195-202, 1965.Crossref 13. Chauncey, H.H.; Shklar, G.; and Brooks, R.A.: Histochemistry of Human Salivary Gland Tumors , Oral Surg 15:950-964, 1962.Crossref 14. Beaulaton, J.: Sur l'accumulation intramitochondriale de glycogène dans la glande prothoracique du Ver à soie du Chêne Antheraea pernyi (Guér.) pendant les quatrième et cinquième stades larvaires , C R Acad Sci 258:4139-4141, 1964. 15. Personne, P., and André, J.: Existence de glycogène mitochondrial dans le spermatozoide de la Testacelle , J Microscopie 3:643-650, 1964. 16. Ishikawa, T., and Pei, Y.F.: Intramitochondrial Glycogen Particles in Rat Retinal Receptor Cells , J Cell Biol 25:402-407, 1965.Crossref 17. Tandler, B., and Shipkey, F.H.: Ultrastructure of Warthin's Tumor: II. Crystalloids , J Ultrastruct Res 11:306-314, 1964.Crossref 18. Nakai, T.: The Induction and Ultrastructural Study of Amelanotic Dermal Melanocytoma in the Syrian Albino Hamster , Lab Invest 12:554-562, 1963. 19. Porter, K.R.: " The Ground Substance: Observations From Electron Microscopy ," in Brachet, J., and Mirsky, A.E.: The Cell , New York: Academic Press, Inc., 1961, vol 2, p 652. 20. Wilson, R.B., and McWhorter, C.A.: Isolated Flagella in Human Skin , Lab Invest 12:242-249, 1963. 21. Grillo, M.A., and Palay, S.L.: Ciliated Schwann Cells in the Autonomic Nervous System of the Adult Rat , J Cell Biol 16:430-436, 1963.Crossref 22. Barnes, B.G.: Ciliated Secretory Cel's in the Pars Distalis of the Mouse Hypophysis , J Ultrastruct Res 5:453-467, 1961.Crossref 23. Schuster, F.L.: Ciliated Fibroblasts From a Human Brain Tumor , Anat Rec 150:417-422, 1964.Crossref 24. Sorokin, S.: Centrioles and the Formation of Rudimentary Cilia by Fibroblasts and Smooth Muscle Cells , J Cell Biol 15:363-377, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Warthin's Tumor: Electron Microscopic Studies

Archives of Otolaryngology , Volume 84 (1) – Jul 1, 1966

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1966.00760030070006
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Abstract

Abstract PAPILLARY cystadenoma lymphomatosum, a benign neoplasm of the human parotid gland, was first recognized in 1895 by Hildebrand1 and was accurately described in 1910 by Albrecht and Arzt.2 This tumor acquired its eponymic designation in 1929, when it was described in the American literature by Warthin.3 Warthin's tumor is thought to arise from salivary gland structures incorporated in lymph nodes adjacent to or embedded in the parotid gland.4,5 Azzopardi and Hou4 have demonstrated direct histological transition from normal ducts to tumor epithelium. Smith5 considers Warthin's tumor to be the result of metaplastic and neoplastic alteration of salivary gland ductal epithelium accompanied by an increase in lymphoid tissue. In the light microscope, Warthin's tumor is seen to be made up of blunt, papillomatous processes, which consist of masses of lymphoid cells covered by a layer of pseudostratified epithelium.6 These processes project into cystic spaces References 1. Hildebrand, O.: Uber angeborene epitheliale Cysten und Fisteln des Halses , Arch Klin Chir 49:167-192, 1895. 2. Albrecht, H., and Arzt, L.: Beiträge zur Frage der Gewebsverirrung: Papilläre Cystadenome in Lymphdrüsen , Z Path 4:47-69, 1910. 3. Warthin, A.S.: Papillary Cystadenoma Lymphomatosum: A Rare Teratoid of the Parotid Region , J Cancer Res 13:116-125, 1929. 4. Azzopardi, J.G., and Hou, L.T.: The Genesis of Adenolymphoma , J Path Bact 88:213-218, 1964.Crossref 5. Smith, J.F.: Classification of Major Salivary Gland Lesions , Arch Otolaryng 80:322-349, 1964.Crossref 6. Tandler, B., and Shipkey, F.H.: Ultrastructure of Warthin's Tumor: I. Mitochondria , J Ultrastruct Res 11:292-305, 1964.Crossref 7. Fisher, E.R., and Sharkey, D.A.: The Ultrastructure of Colonic Polyps and Cancer With Special Reference to the Epithelial Inclusion Bodies of Leuchtenberger , Cancer 15:160-170, 1962.Crossref 8. Ito, S.: The Enteric Surface Coat on Cat Intestinal Microvilli , J Cell Biol 27:475-491, 1965.Crossref 9. Fawcett, D.W.: Surface Specializations of Absorbing Cells , J Histochem Cytochem 13:75-91, 1965.Crossref 10. Azzopardi, J.G., and Smith, O.D.: Salivary Gland Tumors and Their Mucins , J Path Bact 77:131-140, 1959.Crossref 11. Balogh, K., Jr., and Roth, S.I.: Histochemical and Electron Microscopic Studies of Eosinophilic Granular Cells (Oncocytes) in Tumors of the Parotid Gland , Lab Invest 14:310-320, 1965. 12. McGavran, M.H.: The Ultrastructure of Papillary Cystadenoma Lymphomatosum of the Parotid Gland , Virchow Arch Path Anat 338:195-202, 1965.Crossref 13. Chauncey, H.H.; Shklar, G.; and Brooks, R.A.: Histochemistry of Human Salivary Gland Tumors , Oral Surg 15:950-964, 1962.Crossref 14. Beaulaton, J.: Sur l'accumulation intramitochondriale de glycogène dans la glande prothoracique du Ver à soie du Chêne Antheraea pernyi (Guér.) pendant les quatrième et cinquième stades larvaires , C R Acad Sci 258:4139-4141, 1964. 15. Personne, P., and André, J.: Existence de glycogène mitochondrial dans le spermatozoide de la Testacelle , J Microscopie 3:643-650, 1964. 16. Ishikawa, T., and Pei, Y.F.: Intramitochondrial Glycogen Particles in Rat Retinal Receptor Cells , J Cell Biol 25:402-407, 1965.Crossref 17. Tandler, B., and Shipkey, F.H.: Ultrastructure of Warthin's Tumor: II. Crystalloids , J Ultrastruct Res 11:306-314, 1964.Crossref 18. Nakai, T.: The Induction and Ultrastructural Study of Amelanotic Dermal Melanocytoma in the Syrian Albino Hamster , Lab Invest 12:554-562, 1963. 19. Porter, K.R.: " The Ground Substance: Observations From Electron Microscopy ," in Brachet, J., and Mirsky, A.E.: The Cell , New York: Academic Press, Inc., 1961, vol 2, p 652. 20. Wilson, R.B., and McWhorter, C.A.: Isolated Flagella in Human Skin , Lab Invest 12:242-249, 1963. 21. Grillo, M.A., and Palay, S.L.: Ciliated Schwann Cells in the Autonomic Nervous System of the Adult Rat , J Cell Biol 16:430-436, 1963.Crossref 22. Barnes, B.G.: Ciliated Secretory Cel's in the Pars Distalis of the Mouse Hypophysis , J Ultrastruct Res 5:453-467, 1961.Crossref 23. Schuster, F.L.: Ciliated Fibroblasts From a Human Brain Tumor , Anat Rec 150:417-422, 1964.Crossref 24. Sorokin, S.: Centrioles and the Formation of Rudimentary Cilia by Fibroblasts and Smooth Muscle Cells , J Cell Biol 15:363-377, 1962.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Jul 1, 1966

References