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WARNING AGAINST INTRATHECAL USE OF METHYLENE BLUE

WARNING AGAINST INTRATHECAL USE OF METHYLENE BLUE To the Editor:— For at least 30 years methylene blue has been used by neurosurgeons as a dye to color the cerebrospinal fluid. In most instances the dye has been injected into hydrocephalic ventricles in the effort to demonstrate the presence or absence of a block somewhere within the ventricular system. Under these circumstances the dye becomes almost immediately very dilute. Emboldened by the use of the dye in this fashion, neurosurgeons have, on occasion, injected the dye directly or in diluted form into the lumbar subarachnoid space. We recently have used the dye in this fashion drawn from a 10-cc. ampul of aqueous 1% methylene blue solution as used intravenously. In our own case 1 cc. of the dye was diluted in 25 cc. of spinal fluid and was then injected. Shortly thereafter there was discomfort, and then followed a rather profound paraplegia, which fortunately cleared in the course http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

WARNING AGAINST INTRATHECAL USE OF METHYLENE BLUE

JAMA , Volume 169 (5) – Jan 31, 1959

WARNING AGAINST INTRATHECAL USE OF METHYLENE BLUE

Abstract



To the Editor:—
For at least 30 years methylene blue has been used by neurosurgeons as a dye to color the cerebrospinal fluid. In most instances the dye has been injected into hydrocephalic ventricles in the effort to demonstrate the presence or absence of a block somewhere within the ventricular system. Under these circumstances the dye becomes almost immediately very dilute. Emboldened by the use of the dye in this fashion, neurosurgeons have, on...
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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1959.03000220106025
Publisher site
See Article on Publisher Site

Abstract

To the Editor:— For at least 30 years methylene blue has been used by neurosurgeons as a dye to color the cerebrospinal fluid. In most instances the dye has been injected into hydrocephalic ventricles in the effort to demonstrate the presence or absence of a block somewhere within the ventricular system. Under these circumstances the dye becomes almost immediately very dilute. Emboldened by the use of the dye in this fashion, neurosurgeons have, on occasion, injected the dye directly or in diluted form into the lumbar subarachnoid space. We recently have used the dye in this fashion drawn from a 10-cc. ampul of aqueous 1% methylene blue solution as used intravenously. In our own case 1 cc. of the dye was diluted in 25 cc. of spinal fluid and was then injected. Shortly thereafter there was discomfort, and then followed a rather profound paraplegia, which fortunately cleared in the course

Journal

JAMAAmerican Medical Association

Published: Jan 31, 1959

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