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Vitreous Body Volume Reduction in the Rabbit: Effect of Surgical Opening of the Anterior Chamber in the Normal Eye

Vitreous Body Volume Reduction in the Rabbit: Effect of Surgical Opening of the Anterior Chamber... Abstract The anterior chamber of one eye of anesthetized rabbits was surgically opened, simulating the condition which exists prior to cataract extraction in man. Compared to the control eye, the weight of the lens and vitreous was found to diminish at an average rate of 5 mg/min. If it is assumed that the observed weight loss is due to loss of vitreous water, the volume of the vitreous compartment will have diminished by 50μl ten minutes after opening the anterior chamber. This volume is comparable to that lost from the vitreous body as a result of preoperative administration of hyperosmotic agents. It is speculated that the fluid loss from the vitreous body resulting from opening the anterior chamber will not be affected by preoperative maneuvers used to reduce the volume of the vitreous compartment. References 1. Kirsch RE, Steinman W: Digital pressure: An important safeguard in cataract surgery . Arch Ophthal 54:697-783, 1955.Crossref 2. Kirsch RE: Further studies on the use of digital pressure in cataract surgery . Arch Ophthal 58:641-646, 1957.Crossref 3. Kettesy A: Loss of vitreous: Incidence, significance, causes and preventive measures . Klin Mbl Augenheilk 150:785-804, 1967. 4. Robbins R, Blumenthal M, Galin MA: Reduction of vitreous weight by ocular massage . Amer J Ophthal 69:603-607, 1970. 5. Davis MD, Duehr PA, Javid M: The clinical use of urea for reduction of intraocular pressure . Arch Ophthal 65:526-531, 1961.Crossref 6. Bucci MG: Weight changes of the vitreous body after oral glycerol administration in rabbits . Boll Oculist 42:569-577, 1963. 7. Virno M, Cantore P, Bietti C, et al: Oral glycerol in ophthalmology: A valuable new method for the reduction of intraocular pressure . Amer J Ophthal 55:1133-1142, 1963. 8. Jaffe NS, Light DS: Oral glycerin in cataract surgery . Arch Ophthal 73:516-518, 1965.Crossref 9. Galin MA, Davidson R, Shachter N: Ophthalmological use of osmotic therapy . Amer J Ophthal 62:629-634, 1966. 10. Awasthi P, Mathur SP, Srivastava MP: Oral glycerol in cataract surgery . Brit J Ophthal 51:130-131, 1967.Crossref 11. Becker B, Kolker AE, Krupin T: Isosorbide: An oral hyperosmotic agent . Arch Ophthal 78:147-150, 1967.Crossref 12. Krudysz J: Glycerol in the treatment of glaucoma . Klin Oczna 37:645-649, 1967. 13. Bucci MG, Santillo C, Pecori Giraldi J: Quantitative determination of vitreous participation to the ocular hypotonizing effect of osmotic substances . Boll Oculist 47:638-651, 1968. 14. Muto K: Experimental study of effects of osmotic agents on vitreous . Acta Soc Ophthal Jap 73:2070-2081, 1969. 15. Robbins R, Galin MA: Effect of osmotic agents on the vitreous body . Arch Ophthal 82:694-699, 1969.Crossref 16. Krupin T, Kolker AE, Becker B: A comparison of isosorbide and glycerol for cataract surgery . Amer J Ophthal 69:737-740, 1970. 17. Duncan LS Jr, Ellis PP, Paterson CA: Effect of hyperosmotic agents on vitreous osmolality . Exp Eye Res 10:129-132, 1970.Crossref 18. Agarwal LP, Gupta RBL, Malik SRK: Drug administration in cataract surgery . Brit J Ophthal 43:302-308, 1959.Crossref 19. Gartner S: Methods of inducing anesthesia and hypotony for cataract surgery . Arch Ophthal 61:50-54, 1959.Crossref 20. Robbins RM, Obstbaum SA, Galin MA: Intraocular pressure rebound . Brit J Ophthal 55:177-182, 1971.Crossref 21. Galin MA, Robbins R, Obstbaum SA: Prevention of vitreous loss . Brit J Ophthal 55:533-537, 1971.Crossref 22. Bárány EH: The immediate effect on outflow resistance of intravenous pilocarpine in the vervet monkey, Cercopithecus ethiops . Invest Ophthal 6:373-380, 1967. 23. Field J, Tainter EG, Martin AW, et al: Studies on the oxygen consumption of the rabbit lens and the effect of 2-4 Dinitrophenol Thereon . Amer J Ophthal 20:779-794, 1937. 24. Visser-Heerema J: Ueber das Spezifische Gewicht der bei der Operation von Netzhautablösungen gewonnenen Flüssigkeit . Arch Augenheilk 109:543-561, 1936. 25. DeVincentiis M: Further observations on the content of pyruvic and lactic acid in the vitreous humour . Boll Soc Ital Biol Sper 27:309-312, 1951. 26. Langham ME, Heald K: Factors affecting the concentration of ascorbic acid in the crystalline lens of cattle and rabbits . Biochem J 63:52-56, 1956. 27. Kinsey VE, Grant M, Cogan DG: Water movement and the eye . Arch Ophthal 27:242-252, 1942.Crossref 28. Maurice DM: The permeability to sodium ions of the living rabbit's cornea . J Physiol 112:367-391, 1951. 29. Kinsey VE, Reddy DVN, Skrentny G: Intraocular transport of C14-labeled urea and the influence of Diamox on its rate of accumulation in aqueous humors . Amer J Ophthal 50:1130-1141, 1960. 30. Kinsey VE, Reddy DVN: Chemistry and dynamics of aqueous humor , in Prince JH (ed): The Rabbit in Eye Research . Springfield, Ill, Charles C Thomas Publisher, 1964, p 254. 31. Bárány EH: A mathematical formulation of intraocular pressure as dependent on secretion, ultrafiltration, bulk outflow, and osmotic reabsorption of fluid . Invest Ophthal 2:584-590, 1963. 32. Brubaker RF: Determination of episcleral venous pressure in the eye . Arch Ophthal 77:110-114, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Vitreous Body Volume Reduction in the Rabbit: Effect of Surgical Opening of the Anterior Chamber in the Normal Eye

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1972.01000020440014
Publisher site
See Article on Publisher Site

Abstract

Abstract The anterior chamber of one eye of anesthetized rabbits was surgically opened, simulating the condition which exists prior to cataract extraction in man. Compared to the control eye, the weight of the lens and vitreous was found to diminish at an average rate of 5 mg/min. If it is assumed that the observed weight loss is due to loss of vitreous water, the volume of the vitreous compartment will have diminished by 50μl ten minutes after opening the anterior chamber. This volume is comparable to that lost from the vitreous body as a result of preoperative administration of hyperosmotic agents. It is speculated that the fluid loss from the vitreous body resulting from opening the anterior chamber will not be affected by preoperative maneuvers used to reduce the volume of the vitreous compartment. References 1. Kirsch RE, Steinman W: Digital pressure: An important safeguard in cataract surgery . Arch Ophthal 54:697-783, 1955.Crossref 2. Kirsch RE: Further studies on the use of digital pressure in cataract surgery . Arch Ophthal 58:641-646, 1957.Crossref 3. Kettesy A: Loss of vitreous: Incidence, significance, causes and preventive measures . Klin Mbl Augenheilk 150:785-804, 1967. 4. Robbins R, Blumenthal M, Galin MA: Reduction of vitreous weight by ocular massage . Amer J Ophthal 69:603-607, 1970. 5. Davis MD, Duehr PA, Javid M: The clinical use of urea for reduction of intraocular pressure . Arch Ophthal 65:526-531, 1961.Crossref 6. Bucci MG: Weight changes of the vitreous body after oral glycerol administration in rabbits . Boll Oculist 42:569-577, 1963. 7. Virno M, Cantore P, Bietti C, et al: Oral glycerol in ophthalmology: A valuable new method for the reduction of intraocular pressure . Amer J Ophthal 55:1133-1142, 1963. 8. Jaffe NS, Light DS: Oral glycerin in cataract surgery . Arch Ophthal 73:516-518, 1965.Crossref 9. Galin MA, Davidson R, Shachter N: Ophthalmological use of osmotic therapy . Amer J Ophthal 62:629-634, 1966. 10. Awasthi P, Mathur SP, Srivastava MP: Oral glycerol in cataract surgery . Brit J Ophthal 51:130-131, 1967.Crossref 11. Becker B, Kolker AE, Krupin T: Isosorbide: An oral hyperosmotic agent . Arch Ophthal 78:147-150, 1967.Crossref 12. Krudysz J: Glycerol in the treatment of glaucoma . Klin Oczna 37:645-649, 1967. 13. Bucci MG, Santillo C, Pecori Giraldi J: Quantitative determination of vitreous participation to the ocular hypotonizing effect of osmotic substances . Boll Oculist 47:638-651, 1968. 14. Muto K: Experimental study of effects of osmotic agents on vitreous . Acta Soc Ophthal Jap 73:2070-2081, 1969. 15. Robbins R, Galin MA: Effect of osmotic agents on the vitreous body . Arch Ophthal 82:694-699, 1969.Crossref 16. Krupin T, Kolker AE, Becker B: A comparison of isosorbide and glycerol for cataract surgery . Amer J Ophthal 69:737-740, 1970. 17. Duncan LS Jr, Ellis PP, Paterson CA: Effect of hyperosmotic agents on vitreous osmolality . Exp Eye Res 10:129-132, 1970.Crossref 18. Agarwal LP, Gupta RBL, Malik SRK: Drug administration in cataract surgery . Brit J Ophthal 43:302-308, 1959.Crossref 19. Gartner S: Methods of inducing anesthesia and hypotony for cataract surgery . Arch Ophthal 61:50-54, 1959.Crossref 20. Robbins RM, Obstbaum SA, Galin MA: Intraocular pressure rebound . Brit J Ophthal 55:177-182, 1971.Crossref 21. Galin MA, Robbins R, Obstbaum SA: Prevention of vitreous loss . Brit J Ophthal 55:533-537, 1971.Crossref 22. Bárány EH: The immediate effect on outflow resistance of intravenous pilocarpine in the vervet monkey, Cercopithecus ethiops . Invest Ophthal 6:373-380, 1967. 23. Field J, Tainter EG, Martin AW, et al: Studies on the oxygen consumption of the rabbit lens and the effect of 2-4 Dinitrophenol Thereon . Amer J Ophthal 20:779-794, 1937. 24. Visser-Heerema J: Ueber das Spezifische Gewicht der bei der Operation von Netzhautablösungen gewonnenen Flüssigkeit . Arch Augenheilk 109:543-561, 1936. 25. DeVincentiis M: Further observations on the content of pyruvic and lactic acid in the vitreous humour . Boll Soc Ital Biol Sper 27:309-312, 1951. 26. Langham ME, Heald K: Factors affecting the concentration of ascorbic acid in the crystalline lens of cattle and rabbits . Biochem J 63:52-56, 1956. 27. Kinsey VE, Grant M, Cogan DG: Water movement and the eye . Arch Ophthal 27:242-252, 1942.Crossref 28. Maurice DM: The permeability to sodium ions of the living rabbit's cornea . J Physiol 112:367-391, 1951. 29. Kinsey VE, Reddy DVN, Skrentny G: Intraocular transport of C14-labeled urea and the influence of Diamox on its rate of accumulation in aqueous humors . Amer J Ophthal 50:1130-1141, 1960. 30. Kinsey VE, Reddy DVN: Chemistry and dynamics of aqueous humor , in Prince JH (ed): The Rabbit in Eye Research . Springfield, Ill, Charles C Thomas Publisher, 1964, p 254. 31. Bárány EH: A mathematical formulation of intraocular pressure as dependent on secretion, ultrafiltration, bulk outflow, and osmotic reabsorption of fluid . Invest Ophthal 2:584-590, 1963. 32. Brubaker RF: Determination of episcleral venous pressure in the eye . Arch Ophthal 77:110-114, 1967.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1972

References