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Vitiligo and Pernicious Anemia

Vitiligo and Pernicious Anemia Abstract It has long been suspected by one of us (A. C. C.) that the combined diagnoses of pernicious anemia and vitiligo occurred in a greater than statistically expected concurrence. To substantiate this observation a survey of patients with either or both diseases was made. Of 801,678 admissions to the University of Michigan Hospital from 1934 through 1954 there were 1398 patients diagnosed as having pernicious anemia, 531 as vitiligo, and 22 patients with the combined diagnosis. Pernicious anemia was present in 0.17% of the patients admitted and 0.066% had vitiligo. Arithmetically then 1.6% of the patients with pernicious anemia had vitiligo and 4.1% of the patients with vitiligo had pernicious anemia (Table). To calculate the theoretical occurrence of the combined diagnoses the formula NP1P2 was used. N equals the total number of patients observed (801,670), P1 equals the frequency of occurrence of patients References 1. Boenheim, F.; Schwimmer, D., and McGavack, T. H.: Combination of Hyperthyroidism and Pernicious Anemia , Ann. Int. Med. 23:869-879, 1945.Crossref 2. Schwartz, S. O., and Gore, M.: Pernicious Anemia in Negroes , Arch. Int. Med. 72:782, 1943.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1955.03730350009002
Publisher site
See Article on Publisher Site

Abstract

Abstract It has long been suspected by one of us (A. C. C.) that the combined diagnoses of pernicious anemia and vitiligo occurred in a greater than statistically expected concurrence. To substantiate this observation a survey of patients with either or both diseases was made. Of 801,678 admissions to the University of Michigan Hospital from 1934 through 1954 there were 1398 patients diagnosed as having pernicious anemia, 531 as vitiligo, and 22 patients with the combined diagnosis. Pernicious anemia was present in 0.17% of the patients admitted and 0.066% had vitiligo. Arithmetically then 1.6% of the patients with pernicious anemia had vitiligo and 4.1% of the patients with vitiligo had pernicious anemia (Table). To calculate the theoretical occurrence of the combined diagnoses the formula NP1P2 was used. N equals the total number of patients observed (801,670), P1 equals the frequency of occurrence of patients References 1. Boenheim, F.; Schwimmer, D., and McGavack, T. H.: Combination of Hyperthyroidism and Pernicious Anemia , Ann. Int. Med. 23:869-879, 1945.Crossref 2. Schwartz, S. O., and Gore, M.: Pernicious Anemia in Negroes , Arch. Int. Med. 72:782, 1943.Crossref

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1955

References