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Vitamin K Deficiency Associated with Prolonged Antibiotic Administration

Vitamin K Deficiency Associated with Prolonged Antibiotic Administration Abstract Vitamin K deficiency as the cause of a hemorrhagic diathesis has been recognized for many years. Clinical deficiency of this vitamin has usually been associated with some defect in absorption from the gastrointestinal tract, such as that associated with biliary-tract obstruction or with sprue. Dietary deficiency of vitamin K has not been important because of the ability of the normal intestinal bacteria to synthesize vitamin K. Since the introduction of the broadspectrum antibiotics it has become possible to greatly reduce the bacterial content of the intestine and, as a consequence, to decrease the amount of vitamin K produced. The fact that this can occasionally produce a severe hemorrhagic diathesis is attested by the following case. Report of Case A 46-year-old white woman was admitted to the urology service of the Medical College of Virginia Hospital on June 6, 1956, because of right ureteral obstruction and chronic renal infection. Five years References 1. Brinkhous, K. M.: Plasma Prothrombin: Vitamin K , Medicine 19:329-416 ( (Sept.) ) 1940.Crossref 2. Almquist, H. J.; Pentler, C. F., and Mecchi, F.: Synthesis of the Antihemorrhagic Vitamin by Bacteria , Proc. Soc. Exper. Biol. & Med. 38:336-338 ( (April) ) 1938. 3. Butt, H. R.; Snell, A. N., and Osterberg, A. E.: Further Observations on the Use of Vitamin K in the Prevention and Control of the Hemorrhagic Diathesis in Cases of Jaundice , Proc. Staff. Meet. Mayo Clin. 13:753-761 ( (Nov. 30) ) 1938. 4. Lewis, J. H.; Ferguson, J. H.; Spaugh, E.; Fresh, J. W., and Zucker, M. B.: Acquired Hypoprothrombinemia , Blood 12:84-89 ( (Jan.) ) 1957. 5. Castle, W. B.: Disorders of the Blood , in Pathologic Physiology: Mechanisms of Disease , edited by W. A. Sodeman, Ed. 2, Philadelphia, W. B. Saunders Company, 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

Vitamin K Deficiency Associated with Prolonged Antibiotic Administration

A.M.A. Archives of Internal Medicine , Volume 100 (6) – Dec 1, 1957

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1957.00260120130015
Publisher site
See Article on Publisher Site

Abstract

Abstract Vitamin K deficiency as the cause of a hemorrhagic diathesis has been recognized for many years. Clinical deficiency of this vitamin has usually been associated with some defect in absorption from the gastrointestinal tract, such as that associated with biliary-tract obstruction or with sprue. Dietary deficiency of vitamin K has not been important because of the ability of the normal intestinal bacteria to synthesize vitamin K. Since the introduction of the broadspectrum antibiotics it has become possible to greatly reduce the bacterial content of the intestine and, as a consequence, to decrease the amount of vitamin K produced. The fact that this can occasionally produce a severe hemorrhagic diathesis is attested by the following case. Report of Case A 46-year-old white woman was admitted to the urology service of the Medical College of Virginia Hospital on June 6, 1956, because of right ureteral obstruction and chronic renal infection. Five years References 1. Brinkhous, K. M.: Plasma Prothrombin: Vitamin K , Medicine 19:329-416 ( (Sept.) ) 1940.Crossref 2. Almquist, H. J.; Pentler, C. F., and Mecchi, F.: Synthesis of the Antihemorrhagic Vitamin by Bacteria , Proc. Soc. Exper. Biol. & Med. 38:336-338 ( (April) ) 1938. 3. Butt, H. R.; Snell, A. N., and Osterberg, A. E.: Further Observations on the Use of Vitamin K in the Prevention and Control of the Hemorrhagic Diathesis in Cases of Jaundice , Proc. Staff. Meet. Mayo Clin. 13:753-761 ( (Nov. 30) ) 1938. 4. Lewis, J. H.; Ferguson, J. H.; Spaugh, E.; Fresh, J. W., and Zucker, M. B.: Acquired Hypoprothrombinemia , Blood 12:84-89 ( (Jan.) ) 1957. 5. Castle, W. B.: Disorders of the Blood , in Pathologic Physiology: Mechanisms of Disease , edited by W. A. Sodeman, Ed. 2, Philadelphia, W. B. Saunders Company, 1956.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1957

References