Opinion EDITORIAL Vitamin D to Treat COVID-19 Different Disease, Same Answer David E. Leaf, MD, MMSc; Adit A. Ginde, MD, MPH Biological activity of vitamin D and its metabolites include, eficial effects in patients who are already infected because among other properties, potent antimicrobial and anti- SARS-CoV-2–mediated downregulation of ACE2 may per- 1 11 petuate lung injury. inflammatory effects in vitro. In animal models, administra- tion of vitamin D metabolites attenuates a variety of acute or- In this issue of JAMA, Murai et al examine the therapeu- gan dysfunction, including tic efficacy of vitamin D administration in patients with acute lung injury. Observa- COVID-19. The authors enrolled 240 hospitalized patients Related article tional data from patient co- with moderate to severe COVID-19 admitted to 2 hospitals in horts support the potential therapeutic application of these Brazil and randomly assigned them to receive a single dose findings. Specifically, lower circulating levels of vitamin D me- of vitamin D (200 000 IU) or placebo. Approximately 90% of tabolites are independently associated with worse outcomes the patients in both groups required supplemental oxygen or in patients with acute illness, including patients with corona- noninvasive mechanical ventilation at enrollment, but pa- virus disease
JAMA – American Medical Association
Published: Mar 16, 2021
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