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VITAMIN D2 IN THE TREATMENT OF PSORIASIS

VITAMIN D2 IN THE TREATMENT OF PSORIASIS Abstract The use of vitamin D in the treatment of psoriasis has been advocated by Krafka1 and Ceder and Zon2 after the encouraging results they obtained. Other authors, however, reported equivocal or unimpressive results (Wright,3 Pascher and co-workers4 and Clarke5). One of the drawbacks of using vitamin D has been the possibility of toxic reactions. Recently, refinements of production have eliminated some of the toxic substances responsible for undesirable side effects. In an attempt to evaluate the effects of a modern preparation of vitamin D2, a limited number of unselected patients with psoriasis were treated with a sterile solution of persic oil and ether containing 600,000 U. S. P. units of crystalline vitamin D2 per cubic centimeter.6 METHOD Prior to treatment, the history of each patient was taken. A complete physical examination was performed, after which a skin specimen was taken for biopsy. References 1. Krafka, J., Jr.: A Simple Treatment for Psoriasis , J. Lab. & Clin. Med. 21:1147-1148, 1936; 2. Vitamin D Therapy in Psoriasis , J. M. A. Georgia 30:398-400, 1941. 3. Ceder, E. T., and Zon, L.: Treatment of Psoriasis with Massive Doses of Crystalline Vitamin D and Irradiated Ergosterol: Preliminary Report , Pub. Health Rep. 52:1580-1584, 1937. 4. Wright, C. S.: Vitamin D Therapy in Dermatology , Arch. Dermat. & Syph. 43:145-154 ( (Jan.) ) 1941. 5. Pascher, F.; Silverberg, M. G.; Marks, I. E., and Markel, J.: Therapeutic Assays of the New York Skin and Cancer Unit, Post Graduate Medical School, New York University-Bellevue Medical Center: Assay II—Calciferol (D2) , J. Invest. Dermat. 12:193-202, 1949. 6. Clarke, G. E.: Treatment of Psoriasis with Concentrated Viosterol , Arch. Dermat. & Syph. 41:664-666, 1940. 7. Metadee,® furnished by Sharp & Dohme, Inc., Philadelphia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1951 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1951.01570020088013
Publisher site
See Article on Publisher Site

Abstract

Abstract The use of vitamin D in the treatment of psoriasis has been advocated by Krafka1 and Ceder and Zon2 after the encouraging results they obtained. Other authors, however, reported equivocal or unimpressive results (Wright,3 Pascher and co-workers4 and Clarke5). One of the drawbacks of using vitamin D has been the possibility of toxic reactions. Recently, refinements of production have eliminated some of the toxic substances responsible for undesirable side effects. In an attempt to evaluate the effects of a modern preparation of vitamin D2, a limited number of unselected patients with psoriasis were treated with a sterile solution of persic oil and ether containing 600,000 U. S. P. units of crystalline vitamin D2 per cubic centimeter.6 METHOD Prior to treatment, the history of each patient was taken. A complete physical examination was performed, after which a skin specimen was taken for biopsy. References 1. Krafka, J., Jr.: A Simple Treatment for Psoriasis , J. Lab. & Clin. Med. 21:1147-1148, 1936; 2. Vitamin D Therapy in Psoriasis , J. M. A. Georgia 30:398-400, 1941. 3. Ceder, E. T., and Zon, L.: Treatment of Psoriasis with Massive Doses of Crystalline Vitamin D and Irradiated Ergosterol: Preliminary Report , Pub. Health Rep. 52:1580-1584, 1937. 4. Wright, C. S.: Vitamin D Therapy in Dermatology , Arch. Dermat. & Syph. 43:145-154 ( (Jan.) ) 1941. 5. Pascher, F.; Silverberg, M. G.; Marks, I. E., and Markel, J.: Therapeutic Assays of the New York Skin and Cancer Unit, Post Graduate Medical School, New York University-Bellevue Medical Center: Assay II—Calciferol (D2) , J. Invest. Dermat. 12:193-202, 1949. 6. Clarke, G. E.: Treatment of Psoriasis with Concentrated Viosterol , Arch. Dermat. & Syph. 41:664-666, 1940. 7. Metadee,® furnished by Sharp & Dohme, Inc., Philadelphia.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Feb 1, 1951

References