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Vitamin D, Pregnancy, Breastfeeding, and Postpartum Multiple Sclerosis Relapses

Vitamin D, Pregnancy, Breastfeeding, and Postpartum Multiple Sclerosis Relapses ORIGINAL CONTRIBUTION ONLINE FIRST Vitamin D, Pregnancy, Breastfeeding, and Postpartum Multiple Sclerosis Relapses Annette Langer-Gould, MD, PhD; Stella Huang, MS, DO; Stephen K. Van Den Eeden, PhD; Rohit Gupta, BS; Amethyst D. Leimpeter, MS; Kathleen B. Albers, MPH; Ron Horst, PhD; Bruce Hollis, PhD; Lawrence Steinman, MD; Lorene M. Nelson, PhD Objective: To determine whether low levels of Results: Fourteen (50%) women breastfed exclusively, and 25-hydroxyvitamin D (25[OH]D) contribute to the 12 women (43%) relapsed within 6 months after giving increased risk of postpartum multiple sclerosis (MS) birth. During pregnancy, the average 25(OH)D levels were relapses. 25.4 ng/mL (range, 13.7-42.6) and were affected only by season (P = .009). In contrast, in the postpartum period, 25 Design: Prospective cohort study. (OH)D levels were significantly affected by breastfeeding and relapse status. Levels of 25(OH)D remained low in the Setting: Outpatients identified through membership rec- exclusive breastfeeding group, yet rose significantly in the ords of Kaiser Permanente Northern California or Stan- nonexclusive breastfeeding group regardless of season ford University outpatient neurology clinics. (P = .007, unadjusted; P = .02, adjusted for season). By 4 and 6 months after childbirth, 25(OH)D levels were, on aver- Patients: Twenty-eight pregnant women with MS. age, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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References (18)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2010.291
pmid
21059988
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION ONLINE FIRST Vitamin D, Pregnancy, Breastfeeding, and Postpartum Multiple Sclerosis Relapses Annette Langer-Gould, MD, PhD; Stella Huang, MS, DO; Stephen K. Van Den Eeden, PhD; Rohit Gupta, BS; Amethyst D. Leimpeter, MS; Kathleen B. Albers, MPH; Ron Horst, PhD; Bruce Hollis, PhD; Lawrence Steinman, MD; Lorene M. Nelson, PhD Objective: To determine whether low levels of Results: Fourteen (50%) women breastfed exclusively, and 25-hydroxyvitamin D (25[OH]D) contribute to the 12 women (43%) relapsed within 6 months after giving increased risk of postpartum multiple sclerosis (MS) birth. During pregnancy, the average 25(OH)D levels were relapses. 25.4 ng/mL (range, 13.7-42.6) and were affected only by season (P = .009). In contrast, in the postpartum period, 25 Design: Prospective cohort study. (OH)D levels were significantly affected by breastfeeding and relapse status. Levels of 25(OH)D remained low in the Setting: Outpatients identified through membership rec- exclusive breastfeeding group, yet rose significantly in the ords of Kaiser Permanente Northern California or Stan- nonexclusive breastfeeding group regardless of season ford University outpatient neurology clinics. (P = .007, unadjusted; P = .02, adjusted for season). By 4 and 6 months after childbirth, 25(OH)D levels were, on aver- Patients: Twenty-eight pregnant women with MS. age,

Journal

JAMA NeurologyAmerican Medical Association

Published: Mar 1, 2011

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