ORIGINAL CONTRIBUTION ONLINE FIRST Vitamin D, Pregnancy, Breastfeeding, and Postpartum Multiple Sclerosis Relapses Annette Langer-Gould, MD, PhD; Stella Huang, MS, DO; Stephen K. Van Den Eeden, PhD; Rohit Gupta, BS; Amethyst D. Leimpeter, MS; Kathleen B. Albers, MPH; Ron Horst, PhD; Bruce Hollis, PhD; Lawrence Steinman, MD; Lorene M. Nelson, PhD Objective: To determine whether low levels of Results: Fourteen (50%) women breastfed exclusively, and 25-hydroxyvitamin D (25[OH]D) contribute to the 12 women (43%) relapsed within 6 months after giving increased risk of postpartum multiple sclerosis (MS) birth. During pregnancy, the average 25(OH)D levels were relapses. 25.4 ng/mL (range, 13.7-42.6) and were affected only by season (P = .009). In contrast, in the postpartum period, 25 Design: Prospective cohort study. (OH)D levels were significantly affected by breastfeeding and relapse status. Levels of 25(OH)D remained low in the Setting: Outpatients identified through membership rec- exclusive breastfeeding group, yet rose significantly in the ords of Kaiser Permanente Northern California or Stan- nonexclusive breastfeeding group regardless of season ford University outpatient neurology clinics. (P = .007, unadjusted; P = .02, adjusted for season). By 4 and 6 months after childbirth, 25(OH)D levels were, on aver- Patients: Twenty-eight pregnant women with MS. age,
JAMA Neurology – American Medical Association
Published: Mar 1, 2011
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