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Vitamin D–Dependent Rickets as a Possible Risk Factor for Multiple Sclerosis

Vitamin D–Dependent Rickets as a Possible Risk Factor for Multiple Sclerosis OBSERVATION Vitamin D–Dependent Rickets as a Possible Risk Factor for Multiple Sclerosis Øivind Torkildsen, MD; Per Morten Knappskog, PhD; Harald I. Nyland, MD, PhD; Kjell-Morten Myhr, MD, PhD Background: Vitamin D–dependent rickets type I Patients: Three patients in 2 families with a co- occurrence of VDDR I and MS. (VDDR I) (OMIM 264700) is a rare hereditary condi- tion caused by a mutation in CYP27B1. Vitamin D is Results: All 3 patients had VDDR I verified by genetic emerging as an important risk factor for susceptibility to testing and fulfilled the Poser criteria for MS. Two of the multiple sclerosis (MS), but there have been no studies patients have undergone magnetic resonance imaging, on the possible association between hereditary rickets and which confirmed the diagnosis of long-lasting MS. this disease. Conclusions: Vitamin D–dependent rickets type I is a Objective: To investigate the association between very uncommon genetic subtype of rickets. We have iden- VDDR I and MS. tified 3 patients with this disease who later developed MS. We propose that VDDR I and possibly other hereditary Design: Case studies. rickets mutations that influence vitamin D metabolism could be risk factors for this disease. Setting: Haukeland University Hospital, Bergen, Norway. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Vitamin D–Dependent Rickets as a Possible Risk Factor for Multiple Sclerosis

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Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.65.6.809
pmid
18541802
Publisher site
See Article on Publisher Site

Abstract

OBSERVATION Vitamin D–Dependent Rickets as a Possible Risk Factor for Multiple Sclerosis Øivind Torkildsen, MD; Per Morten Knappskog, PhD; Harald I. Nyland, MD, PhD; Kjell-Morten Myhr, MD, PhD Background: Vitamin D–dependent rickets type I Patients: Three patients in 2 families with a co- occurrence of VDDR I and MS. (VDDR I) (OMIM 264700) is a rare hereditary condi- tion caused by a mutation in CYP27B1. Vitamin D is Results: All 3 patients had VDDR I verified by genetic emerging as an important risk factor for susceptibility to testing and fulfilled the Poser criteria for MS. Two of the multiple sclerosis (MS), but there have been no studies patients have undergone magnetic resonance imaging, on the possible association between hereditary rickets and which confirmed the diagnosis of long-lasting MS. this disease. Conclusions: Vitamin D–dependent rickets type I is a Objective: To investigate the association between very uncommon genetic subtype of rickets. We have iden- VDDR I and MS. tified 3 patients with this disease who later developed MS. We propose that VDDR I and possibly other hereditary Design: Case studies. rickets mutations that influence vitamin D metabolism could be risk factors for this disease. Setting: Haukeland University Hospital, Bergen, Norway.

Journal

JAMA NeurologyAmerican Medical Association

Published: Jun 1, 2008

References