ORIGINAL INVESTIGATION Vitamin D and Risk of Cognitive Decline in Elderly Persons David J. Llewellyn, PhD; Iain A. Lang, PhD; Kenneth M. Langa, MD, PhD; Graciela Muniz-Terrera, PhD; Caroline L. Phillips, MS; Antonio Cherubini, MD; Luigi Ferrucci, MD, PhD; David Melzer, PhD Background: To our knowledge, no prospective study the MMSE in participants who were severely serum 25 has examined the association between vitamin D and cog- (OH)D deficient (levels25 nmol/L) in comparison with nitive decline or dementia. those with sufficient levels of 25(OH)D (75 nmol/L) was 1.60 (95% CI, 1.19-2.00). Multivariate adjusted ran- Methods: We determined whether low levels of serum dom-effects models demonstrated that the scores of par- 25-hydroxyvitamin D (25[OH]D) were associated with an ticipants who were severely 25(OH)D deficient de- increased risk of substantial cognitive decline in the clined by an additional 0.3 MMSE points per year more InCHIANTI population–based study conducted in Italy be- than those with sufficient levels of 25(OH)D. The rela- tween 1998 and 2006 with follow-up assessments every tive risk for substantial decline on Trail-Making Test B 3 years. A total of 858 adults 65 years or older completed was 1.31 (95% CI, 1.03-1.51) among those who were se- interviews, cognitive
JAMA Internal Medicine – American Medical Association
Published: Jul 12, 2010
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