Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Vitamin D and Risk of Cognitive Decline in Elderly Persons

Vitamin D and Risk of Cognitive Decline in Elderly Persons ORIGINAL INVESTIGATION Vitamin D and Risk of Cognitive Decline in Elderly Persons David J. Llewellyn, PhD; Iain A. Lang, PhD; Kenneth M. Langa, MD, PhD; Graciela Muniz-Terrera, PhD; Caroline L. Phillips, MS; Antonio Cherubini, MD; Luigi Ferrucci, MD, PhD; David Melzer, PhD Background: To our knowledge, no prospective study the MMSE in participants who were severely serum 25 has examined the association between vitamin D and cog- (OH)D deficient (levels25 nmol/L) in comparison with nitive decline or dementia. those with sufficient levels of 25(OH)D (75 nmol/L) was 1.60 (95% CI, 1.19-2.00). Multivariate adjusted ran- Methods: We determined whether low levels of serum dom-effects models demonstrated that the scores of par- 25-hydroxyvitamin D (25[OH]D) were associated with an ticipants who were severely 25(OH)D deficient de- increased risk of substantial cognitive decline in the clined by an additional 0.3 MMSE points per year more InCHIANTI population–based study conducted in Italy be- than those with sufficient levels of 25(OH)D. The rela- tween 1998 and 2006 with follow-up assessments every tive risk for substantial decline on Trail-Making Test B 3 years. A total of 858 adults 65 years or older completed was 1.31 (95% CI, 1.03-1.51) among those who were se- interviews, cognitive http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Vitamin D and Risk of Cognitive Decline in Elderly Persons

Download PDF
7 pages
Read Article

Loading next page...
 
/lp/american-medical-association/vitamin-d-and-risk-of-cognitive-decline-in-elderly-persons-RF7Fow8Y0p
Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2010.173
pmid
20625021
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Vitamin D and Risk of Cognitive Decline in Elderly Persons David J. Llewellyn, PhD; Iain A. Lang, PhD; Kenneth M. Langa, MD, PhD; Graciela Muniz-Terrera, PhD; Caroline L. Phillips, MS; Antonio Cherubini, MD; Luigi Ferrucci, MD, PhD; David Melzer, PhD Background: To our knowledge, no prospective study the MMSE in participants who were severely serum 25 has examined the association between vitamin D and cog- (OH)D deficient (levels25 nmol/L) in comparison with nitive decline or dementia. those with sufficient levels of 25(OH)D (75 nmol/L) was 1.60 (95% CI, 1.19-2.00). Multivariate adjusted ran- Methods: We determined whether low levels of serum dom-effects models demonstrated that the scores of par- 25-hydroxyvitamin D (25[OH]D) were associated with an ticipants who were severely 25(OH)D deficient de- increased risk of substantial cognitive decline in the clined by an additional 0.3 MMSE points per year more InCHIANTI population–based study conducted in Italy be- than those with sufficient levels of 25(OH)D. The rela- tween 1998 and 2006 with follow-up assessments every tive risk for substantial decline on Trail-Making Test B 3 years. A total of 858 adults 65 years or older completed was 1.31 (95% CI, 1.03-1.51) among those who were se- interviews, cognitive

Journal

JAMA Internal Medicine – American Medical Association

Published: Jul 12, 2010

References

  • Vitamin D deficiency.
    Holick, MF
  • Serum vitamin D concentrations among elderly people in Europe.
    van der Wielen, RP; Lowik, MR; van den Berg, H
  • Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials.
    Autier, P; Gandini, S
  • Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
    Bischoff-Ferrari, HA; Willett, WC; Wong, JB; Giovannucci, E; Dietrich, T; Dawson-Hughes, B
  • Vitamin D in health and disease.
    Heaney, RP
  • Global prevalence of dementia: a Delphi consensus study.
    Ferri, CP; Prince, M; Brayne, C
  • Prevalence of cognitive impairment without dementia in the United States.
    Plassman, BL; Langa, KM; Fisher, GG
  • Prevalence of dementia in the United States: the aging, demographics, and memory study.
    Plassman, BL; Langa, KM; Fisher, GG
  • Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?
    McCann, JC; Ames, BN
  • Vitamin D and neurocognitive dysfunction: preventing “D”ecline?
    Buell, JS; Dawson-Hughes, B
  • 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients.
    Masoumi, A; Goldenson, B; Ghirmai, S
  • New clues about vitamin D functions in the nervous system.
    Garcion, E; Wion-Barbot, N; Montero-Menei, CN; Berger, F; Wion, D
  • Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain, I: micronutrients.
    Bourre, JM
  • Vitamin D deficiency associated with self-neglect in the elderly.
    Aung, K; Burnett, J; Smith, SM; Dyer, CB
  • Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels: the Tromso study.
    Jorde, R; Waterloo, K; Saleh, F; Haug, E; Svartberg, J
  • Bone density, vitamin D nutrition, and parathyroid hormone levels in women with dementia.
    Kipen, E; Helme, RD; Wark, JD; Flicker, L
  • Dietary intakes and nutritional status of old people with dementia living at home in Oslo.
    Nes, M; Sem, SW; Rousseau, B
  • Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer's disease.
    Oudshoorn, C; Mattace-Raso, FU; van der Velde, N; Colin, EM; van der Cammen, TJ
  • Is vitamin D important for preserving cognition? a positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function.
    Przybelski, RJ; Binkley, NC
  • Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults.
    Wilkins, CH; Sheline, YI; Roe, CM; Birge, SJ; Morris, JC
  • No association between serum 25-hydroxyvitamin D3 level and performance on psychometric tests in NHANES III.
    McGrath, J; Scragg, R; Chant, D; Eyles, D; Burne, T; Obradovic, D
  • Serum 25-hydroxyvitamin d concentration and cognitive impairment.
    Llewellyn, DJ; Langa, KM; Lang, IA
  • Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
    Lee, DM; Tajar, A; Ulubaev, A
  • Vitamin D is associated with cognitive function in elders receiving home health services.
    Buell, JS; Scott, TM; Dawson-Hughes, B
  • Vitamin D supplementation improves neuromuscular function in older people who fall.
    Dhesi, JK; Jackson, SH; Bearne, LM
  • Rapid correction of low vitamin D status in nursing home residents.
    Przybelski, R; Agrawal, S; Krueger, D; Engelke, JA; Walbrun, F; Binkley, N
  • Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study.
    Ferrucci, L; Bandinelli, S; Benvenuti, E
  • “Mini-Mental State”: a practical method for grading the cognitive state of patients for the clinician.
    Folstein, MF; Folstein, SE; McHugh, PR
  • 25(OH)D serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults.
    Maggio, D; Cherubini, A; Lauretani, F
  • Assessing depressive symptoms across cultures: Italian validation of the CES-D self-rating scale.
    Fava, GA
  • Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres.
    Pisani, P; Faggiano, F; Krogh, V; Palli, D; Vineis, P; Berrino, F
  • Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study.
    Cherubini, A; Martin, A; Andres-Lacueva, C
  • Neighbourhood deprivation and incident mobility disability in older adults.
    Lang, IA; Llewellyn, DJ; Langa, KM; Wallace, RB; Melzer, D
  • What's the relative risk? a method of correcting the odds ratio in cohort studies of common outcomes.
    Zhang, J; Yu, KF
  • Random-effects models for longitudinal data.
    Laird, NM; Ware, JH
  • Estimating the dimension of a model.
    Schwarz, GE
  • Diagnostic and Statistical Manual of Mental Disorders.
  • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis.
    Munger, KL; Levin, LI; Hollis, BW; Howard, NS; Ascherio, A
  • Vitamin D and Parkinson's disease–a hypothesis.
    Newmark, HL; Newmark, J
  • 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons.
    Brown, J; Bianco, JI; McGrath, JJ; Eyles, DW

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial