Abstract ALTHOUGH the role of vitamin C in wound healing has long been known, its behavior during and after surgical operations was not realized until 1937, when it was shown1 that operation or injury increased greatly the need for this vitamin. This was confirmed a few year later.2 Moreover large concentrations of ascorbic acid are mobilized in areas of injury, an observation3 which may explain the increased needs. A second possible relationship between vitamin C and injury was suggested by its behavior in surgical shock. It was shown, for example, that large doses of vitamin C seem to have a beneficial therapeutic effect in experimental hemorrhage4 and traumatic shock5 even when there is no deficit. Other experiments6 showed that animals deficient in vitamin C were less able to resist the effects of injury on the peripheral circulation. While no specific clinical data are available, the References 1. Lanman, T. H., and Ingalls, T. H.: Vitamin C Deficiency and Wound Healing: An Experimental and Clinical Study , Ann. Surg. 105:616, 1937.Crossref 2. Lauber, H. J.: Ueber den Vitamin C-Stoffwechsel bei chirurgischen Erkrankungen und Eingriffen , Arch. f. klin. Chir. 189:282, 1937. 3. Bourne, G. H.: Vitamin C and Repair of Injured Tissues , Lancet 2:661, 1942.Crossref 4. Bartlett, M. K.; Jones, C. M., and Ryan, A. E.: Vitamin C in Surgery , Ann. Surg. 111:1, 1940Crossref 5. Vitamin C and Wound Healing , New England J. Med. 226:469, 1942.Crossref 6. Stewart, C. P.; Learmonth, J. R., and Pollock, G. A.: Intravenous Ascorbic Acid in Experimental Acute Haemorrhage , Lancet 1:818, 1941.Crossref 7. Ungar, G.: Experimental Traumatic "Shock," Lancet 1:421, 1943.Crossref 8. Schneider, E.: Erfassbare Vitaminverlust und ihre Bedeutung fur das Knochensystem , Arch. f. klin. Chir. 189:288, 1937. 9. Holmes, H. N.: Vitamin C in War , Science 96:384, 1942.Crossref 10. Mindlin, R. L., and Butler, A. M.: Determination of Ascorbic Acid in Plasma: Macromethod and Micromethod , J. Biol. Chem. 122:673, 1938. 11. Zerbini, E. de J.: Importance of Ascorbic Acid (Vitamin C) in Chest Surgery , J. Thoracic Surg. 14:309, 1945.
Archives of Surgery – American Medical Association
Published: Feb 1, 1947