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Vitamin B6 in Internal Medicine

Vitamin B6 in Internal Medicine Abstract Introduction Vitamin B6 is required as a growth factor by a wide variety of bacteria, yeasts, and molds and for the nutrition of all species of animals studied. In man it is an essential nutrient, and deficiency of vitamin B6 results in characteristic alterations of the skin, mucous membranes, and nervous system. Like other vitamins, vitamin B6 functions as a coenzyme of importance in a wide variety of enzyme systems concerned with intermediary metabolism.Vitamin B6 is now used as a class name to include all compounds having vitamin B6 activity. These include pyridoxine, pyridoxal, and pyridoxamine. To Gyorgy1 (1934) goes the credit for establishing vitamin B6 as an entity in the vitamin B complex. Within two years of the original observations of Gyorgy, five independent reports announced the isolation of pyridoxine from various natural materials.2-6 In 1939, Harris and Folkers7 successfully synthesized pyridoxine. Snell8 recognized the existence of other References 1. Mixtures of these antibiotics were furnished by Reed & Carnrick (neomycin and bacitracin [Neobacin]) and Burroughs Wellcome & Company, Inc. (polymixin B sulfate [Aerosporin Sulfate]). 2. Blood-group-specific Substances A and B were purchased from the Knickerbocker Blood Bank, New York. 3. Miss Betty Matuska provided technical assistance during the antibody studies. 4. Gyorgy, P.: Vitamin B2 and the Pellagralike Dermatitis in Rats , Nature, London , 133: 498, 1934.Crossref 5. Lepkovsky, I. S.: Crystalline Factor I , Science 87:169, 1938.Crossref 6. Keresztesy, J. C., and Stevens, J. R.: Crystalline Vitamin B-6 , Proc. Soc. Exper. Biol. & Med. 38:64, 1938. 7. Gyorgy, P.: Crystalline Vitamin B6 , J. Am. Chem. Soc. 600:983, 1938. 8. Kahn, R., and Wendt, G.: The Antidermatitis in Yeast , Ber. deutsch. chem. Gesellsch. 71: 780, 1938. 9. Ichiba, A., and Michi, K.: Crystalline Vitamin B6 , Scient. Papers Inst. Phys. & Chem. Res. , Tokyo 34:623, 1938. 10. Harris, S. A., and Folkers, K.: Synthesis of Vitamin B6 , J. Am. Chem. Soc. 61:1245, 1939. 11. Snell, E. E.: The Vitamin B6 Group: I. Formation of Additional Members from Pyridoxine and Evidence Concerning Their Structure , J. Am. Chem. Soc. 66:2082, 1944. 12. Harris, S. A.; Heyl, D., and Folkers, K.: The Structure and Synthesis of Pyridoxamine and Pyridoxal , J. Biol. Chem. 154:315, 1944. 13. Harris, S. A.; Heyl, D., and Folkers, K.: The Vitamin B6 Group: II. The Structure and Synthesis of Pyridoxamine and Pyridoxal , J. Am. Chem. Soc. 66:2088, 1944. 14. Snell, E. E.: Metabolism Significance of B-Vitamins: Symposium; Summary of Known Metabolic Functions of Nicotinic Acid, Riboflavin and Vitamin B6 , Physiol. Rev. 33:509, 1953. 15. Umbreit, W. W., in The Vitamins: Chemistry, Physiology, Pathology , edited by W. H. Sebrell Jr. and R. S. Harris, New York, Academic Press, Inc., 1954, Vol. 3, p. 234. 16. Lepkovsky, S.; Roboz, E., and Haagen-Smith, A. J.: Xanthurenic Acid and Its Role in the Tryptophan Metabolism of Pyridoxine-Deficient Rats , J. Biol. Chem. 149:195, 1943. 17. Lepkovsky, S., and Nielsen, E.: A Green Pigment-Producing Compound in Urine of Pyridoxine-Deficient Rats , J. Biol. Chem. 144:135, 1942. 18. Greenberg, L. D.; Bohr, D. F.; McGrath, H., and Rinehart, J. F.: Xanthurenic Acid Excretion in the Human Subject on a Pyridoxine-Deficient Diet , Arch. Biochem. 21:237, 1949. 19. Sherman, H., in Vitamins andd Hormones: Advances in Research and Application , edited by R. S. Harris and K. V. Thimann, New York, Academic Press, Inc., 1950, Vol. 8, p. 55. 20. Witten, P. W., and Holman, R. T.: Polyethenoid Fatty Acid Metabolism: VI. Effect of Pyridoxine on Essential Fatty Acid Conversions , Arch. Biochem. 41:266, 1952. 21. Elvehjem, C. A.: Role of Intestinal Bacteria in Nutrition , J. Am. Dietet. A. 22:959, 1946. 22. Sarma, P. S.; Snell, E. E., and Elvehjem, C. A.: The Vitamin B6 Group: VIII. Biological Assay of Pyridoxal, Pyridoxamine, and Pyridoxine , J. Biol. Chem. 165:55, 1946. 23. Sauberlich, H. E.: Effect of Aureomycin and Penicillin upon the Vitamin Requirements of the Rat , J. Nutrition 46:99, 1952. 24. Carpenter, K. J.; Harris, L. J., and Kodicek, E.: Pyridoxine and Riboflavin Deficiencies in Rats on Synthetic Diets Containing Succinyl Sulfathiazol , Brit. J. Nutrition 2:VII, 1948. 25. Gyorgy, P.; Sullivan, M., and Karsner, H. T.: Nutritional Dermatoses in Rats , Proc. Soc. Exper. Biol. & Med. 37:313, 1937. 26. Chick, H.; El Sadr, M. M., and Worden, A. M.: Occurrence of Fits of an Epileptiform Nature in Rats Maintained for Long Periods of Time on a Diet Deficient of Vitamin B6 , Biochem. J. 34:595, 1940. 27. Kornberg, A.; Tabor, H., and Sebrell, W. H.: Blood Regeneration in Pyridoxine-Deficient Rats , Am. J. Physiol. 143:434, 1945. 28. Stoerk, H. C.; Eisen, H. N., and John, H. M.: Impairment of Antibody Response in Pyridoxine-Deficient Rats , J. Exper. Med. 85:365, 1947.Crossref 29. Axelrod, A. E.: Role of Vitamins in Antibody Production, in Recent Advances in Nutrition Research with Emphasis on Newer B Vitamins: Proceedings of the Scientific Sessions of the 7th Annual Meeting, National Vitamin Foundation, Inc., New York, April 3, 1952, Nutrition Symposium Series No. 5, edited by A. E. Axelrod et al., New York, National Vitamin Foundation, Inc., 1952, p. 27. 30. Rinehart, J. F., and Greenberg, L. D.: Arteriosclerotic Lesions in Pyridoxine-Deficient Monkeys , Am. J. Path. 25:481, 1949. 31. Cartwright, G. E., and Wintrobe, M. M.: Studies on Free Erythrocyte Protoporphyrin, Plasma Copper, and Plasma Iron in Normal and in Pyridoxine-Deficient Swine , J. Biol. Chem. 172:557, 1948. 32. Scudi, J. V.; Unna, K., and Antopol, W.: A Study of the Urinary Excretion of Vitamin B6 by a Colorimetric Method , J. Biol. Chem. 135:371, 1940. 33. Rabinowitz, J. C., and Snell, E. E.: Vitamin B6 Group: XV. Urinary Excretion of Pyridoxal, Pyridoxamine, Pyridoxine, and 4-Pyridoxic Acid in Human Subjects , Proc. Soc. Exper. Biol. & Med. 70:235, 1949. 34. Moller, P.: Investigations on the Metabolism of Vitamin B6 , Acta physiol. scandinav. 23:47,:47, 1951. 35. Sarett, H. P.: Effect of Oral Administration of Streptomycin on Urinary Excretion of B Vitamins in Man , J. Nutrition 47:275, 1952. 36. di Raimondo, F.; Angarano, D.; Mannino, N., and Trinchese, L.: Collateral Effects of Antibiotics in the Rat, with Special Reference to Metabolism of Vitamins of the B Complex , Internat. Ztschr. Vitaminforsch. 24:276, 1952. 37. di Raimondo, F.; Angarano, D.; Mannino, N., and Trinchese, L.: Side-Effects of Some Antibiotics in Healthy Subjects and in Patients with Special Reference to Urinary Excretion of Vitamins and of the B Complex , Internat. Ztschr. Vitaminforsch. 24:302, 1952. 38. Boxer, G. E.; Pruss, M. P., and Gordhart, R. S.: Determination of Pyridoxal-5-Phosphoric Acid (B6-PO4) in the Whole Blood and Isolated Leukocytes, to be published. 39. Sarett, H. P.: A Study of the Measurement of 4-Pyridoxic Acid in the Urine , J. Biol. Chem. 189:769, 1951. 40. Mueller, J. F., and Vilter, R. W.: Pyridoxine Deficiency in Human Beings Induced with Desoxypyridoxine , J. Clin. Invest. 29:193, 1950. 41. Snyderman, S. E.; Carretero, R., and Holt, L. E., Jr.: Pyridoxine Deficiency in the Human Being , Fed. Proc. 9:371, 1950. 42. Coursin, D. B.: Convulsive Seizures in Infants with Pyridoxine-Deficient Diet , J. A. M. A. 154:406, 1954. 43. Molony, C. J., and Parmelee, A. H.: Convulsions in Young Infants as a Result of Pyridoxine (Vitamin B6) Deficiency , J. A. M. A. 154: 405, 1954. 44. May, C. D.: Vitamin B6 in Human Nutrition: A Critique and an Object Lesson , Pediatrics 14:269, 1954. 45. Hunt, A. D., Jr.; Stokes, J., Jr.; McCrory, W. W., and Stroud, H. H.: Pyridoxine Dependency: Report of a Case of Intractable Convulsions in an Infant Controlled by Pyridoxine , Pediatrics 13:140, 1954. 46. Greenfield, J. G.: Results of Histological Examination of Rats Suffering from Fits. Addendum to footnote 23. 47. Gellhorn, A., and Jones, L. O.: Pyridoxine Deficient Diet and Desoxypyridoxine in the Therapy of Lymphosarcoma and Acute Leukemia in Man , Blood 4:60, 1949. 48. Reilly, R. H.; Killam, K. F.; Jenney, E. H.; Marshall, W. H.; Taussig, T.; Apter, N. S., and Pfeiffer, C. C.: Convulsant Effects of Isoniazid , J. A. M. A. 152:1317, 1953. 49. Tower, D. B.: Neurochemical Aspects of Pyriodoxine Metabolism and Function, in Symposium on the Role of Some of the Newer Vitamins in Human Metabolism and Nutrition: Proceedings of Nutrition Symposium Held at Vanderbilt University School of Medicine, Nashville, Tenn., Oct. 20-21, 1955, Nutrition Symposium Series No. 12, edited by R. D. Adams et al., New York, National Vitamin Foundation, Inc., 1956, p. 21. 50. Vilter, R. W.; Mueller, J. F.; Glazer, H. S.; Jarrold, T.; Abraham, J.; Thompson, C., and Hawkins, V. R.: The Effect of Vitamin B6 Deficiency Induced by Desoxypyridoxine in Human Beings , J. Lab. & Clin. Med. 42:335, 1953. 51. Biehl, J. P., and Vilter, R. W.: Effect of Isoniazid on Vitamin B6 Metabolism: Its Possible Significance in Producing Isoniazid Neuritis , Proc. Soc. Exper. Biol. & Med. 85:389, 1954. 52. Harris, J. W.; Whittington, R. M.; Weisman, R., Jr., and Horrigan, D. L.: Pyridoxine Responsive Anemia in the Human Adult , Proc. Soc. Exper. Biol. & Med. 91:427, 1956. 53. Wachstein, M., and Gudaitis, A.: Disturbance of Vitamin B6 Metabolism in Pregnancy , J. Lab. & Clin. Med. 40:550, 1952. 54. Wachstein, M., and Gudaitis, A.: Disturbance of Vitamin B6 Metabolism in Pregnancy: III. Abnormal Vitamin B6 Load Test , Am. J. Obst. & Gynec. 66:1207, 1953. 55. Friedman, B. I.; Becker, L.; Thompson, C., and Vilter, R. W.: Vitamin B6 Metabolism in the Post-Partum Period , J. Lab. & Clin. Med. 46: 817, 1955. 56. Schreiner, A. W.; Slinger, W. N.; Hawkins, V. R., and Vilter, R. W.: Seborrheic Dermatitis: A Local Metabolic Defect Involving Pyridoxine , J. Lab. & Clin. Med. 40:121, 1952. 57. Effersøe, H.: The Effect of Topical Application of Pyridoxine Ointment on the Rate of Sebaceous Secretion in Patients with Seborrheic Dermatitis , Acta dermat.-venereol. 34:272, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

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Abstract

Abstract Introduction Vitamin B6 is required as a growth factor by a wide variety of bacteria, yeasts, and molds and for the nutrition of all species of animals studied. In man it is an essential nutrient, and deficiency of vitamin B6 results in characteristic alterations of the skin, mucous membranes, and nervous system. Like other vitamins, vitamin B6 functions as a coenzyme of importance in a wide variety of enzyme systems concerned with intermediary metabolism.Vitamin B6 is now used as a class name to include all compounds having vitamin B6 activity. These include pyridoxine, pyridoxal, and pyridoxamine. To Gyorgy1 (1934) goes the credit for establishing vitamin B6 as an entity in the vitamin B complex. Within two years of the original observations of Gyorgy, five independent reports announced the isolation of pyridoxine from various natural materials.2-6 In 1939, Harris and Folkers7 successfully synthesized pyridoxine. Snell8 recognized the existence of other References 1. Mixtures of these antibiotics were furnished by Reed & Carnrick (neomycin and bacitracin [Neobacin]) and Burroughs Wellcome & Company, Inc. (polymixin B sulfate [Aerosporin Sulfate]). 2. Blood-group-specific Substances A and B were purchased from the Knickerbocker Blood Bank, New York. 3. Miss Betty Matuska provided technical assistance during the antibody studies. 4. Gyorgy, P.: Vitamin B2 and the Pellagralike Dermatitis in Rats , Nature, London , 133: 498, 1934.Crossref 5. Lepkovsky, I. S.: Crystalline Factor I , Science 87:169, 1938.Crossref 6. Keresztesy, J. C., and Stevens, J. R.: Crystalline Vitamin B-6 , Proc. Soc. Exper. Biol. & Med. 38:64, 1938. 7. Gyorgy, P.: Crystalline Vitamin B6 , J. Am. Chem. Soc. 600:983, 1938. 8. Kahn, R., and Wendt, G.: The Antidermatitis in Yeast , Ber. deutsch. chem. Gesellsch. 71: 780, 1938. 9. Ichiba, A., and Michi, K.: Crystalline Vitamin B6 , Scient. Papers Inst. Phys. & Chem. Res. , Tokyo 34:623, 1938. 10. Harris, S. A., and Folkers, K.: Synthesis of Vitamin B6 , J. Am. Chem. Soc. 61:1245, 1939. 11. Snell, E. E.: The Vitamin B6 Group: I. Formation of Additional Members from Pyridoxine and Evidence Concerning Their Structure , J. Am. Chem. Soc. 66:2082, 1944. 12. Harris, S. A.; Heyl, D., and Folkers, K.: The Structure and Synthesis of Pyridoxamine and Pyridoxal , J. Biol. Chem. 154:315, 1944. 13. Harris, S. A.; Heyl, D., and Folkers, K.: The Vitamin B6 Group: II. The Structure and Synthesis of Pyridoxamine and Pyridoxal , J. Am. Chem. Soc. 66:2088, 1944. 14. Snell, E. E.: Metabolism Significance of B-Vitamins: Symposium; Summary of Known Metabolic Functions of Nicotinic Acid, Riboflavin and Vitamin B6 , Physiol. Rev. 33:509, 1953. 15. Umbreit, W. W., in The Vitamins: Chemistry, Physiology, Pathology , edited by W. H. Sebrell Jr. and R. S. Harris, New York, Academic Press, Inc., 1954, Vol. 3, p. 234. 16. Lepkovsky, S.; Roboz, E., and Haagen-Smith, A. J.: Xanthurenic Acid and Its Role in the Tryptophan Metabolism of Pyridoxine-Deficient Rats , J. Biol. Chem. 149:195, 1943. 17. Lepkovsky, S., and Nielsen, E.: A Green Pigment-Producing Compound in Urine of Pyridoxine-Deficient Rats , J. Biol. Chem. 144:135, 1942. 18. Greenberg, L. D.; Bohr, D. F.; McGrath, H., and Rinehart, J. F.: Xanthurenic Acid Excretion in the Human Subject on a Pyridoxine-Deficient Diet , Arch. Biochem. 21:237, 1949. 19. Sherman, H., in Vitamins andd Hormones: Advances in Research and Application , edited by R. S. Harris and K. V. Thimann, New York, Academic Press, Inc., 1950, Vol. 8, p. 55. 20. Witten, P. W., and Holman, R. T.: Polyethenoid Fatty Acid Metabolism: VI. Effect of Pyridoxine on Essential Fatty Acid Conversions , Arch. Biochem. 41:266, 1952. 21. Elvehjem, C. A.: Role of Intestinal Bacteria in Nutrition , J. Am. Dietet. A. 22:959, 1946. 22. Sarma, P. S.; Snell, E. E., and Elvehjem, C. A.: The Vitamin B6 Group: VIII. Biological Assay of Pyridoxal, Pyridoxamine, and Pyridoxine , J. Biol. Chem. 165:55, 1946. 23. Sauberlich, H. E.: Effect of Aureomycin and Penicillin upon the Vitamin Requirements of the Rat , J. Nutrition 46:99, 1952. 24. Carpenter, K. J.; Harris, L. J., and Kodicek, E.: Pyridoxine and Riboflavin Deficiencies in Rats on Synthetic Diets Containing Succinyl Sulfathiazol , Brit. J. Nutrition 2:VII, 1948. 25. Gyorgy, P.; Sullivan, M., and Karsner, H. T.: Nutritional Dermatoses in Rats , Proc. Soc. Exper. Biol. & Med. 37:313, 1937. 26. Chick, H.; El Sadr, M. M., and Worden, A. M.: Occurrence of Fits of an Epileptiform Nature in Rats Maintained for Long Periods of Time on a Diet Deficient of Vitamin B6 , Biochem. J. 34:595, 1940. 27. Kornberg, A.; Tabor, H., and Sebrell, W. H.: Blood Regeneration in Pyridoxine-Deficient Rats , Am. J. Physiol. 143:434, 1945. 28. Stoerk, H. C.; Eisen, H. N., and John, H. M.: Impairment of Antibody Response in Pyridoxine-Deficient Rats , J. Exper. Med. 85:365, 1947.Crossref 29. Axelrod, A. E.: Role of Vitamins in Antibody Production, in Recent Advances in Nutrition Research with Emphasis on Newer B Vitamins: Proceedings of the Scientific Sessions of the 7th Annual Meeting, National Vitamin Foundation, Inc., New York, April 3, 1952, Nutrition Symposium Series No. 5, edited by A. E. Axelrod et al., New York, National Vitamin Foundation, Inc., 1952, p. 27. 30. Rinehart, J. F., and Greenberg, L. D.: Arteriosclerotic Lesions in Pyridoxine-Deficient Monkeys , Am. J. Path. 25:481, 1949. 31. Cartwright, G. E., and Wintrobe, M. M.: Studies on Free Erythrocyte Protoporphyrin, Plasma Copper, and Plasma Iron in Normal and in Pyridoxine-Deficient Swine , J. Biol. Chem. 172:557, 1948. 32. Scudi, J. V.; Unna, K., and Antopol, W.: A Study of the Urinary Excretion of Vitamin B6 by a Colorimetric Method , J. Biol. Chem. 135:371, 1940. 33. Rabinowitz, J. C., and Snell, E. E.: Vitamin B6 Group: XV. Urinary Excretion of Pyridoxal, Pyridoxamine, Pyridoxine, and 4-Pyridoxic Acid in Human Subjects , Proc. Soc. Exper. Biol. & Med. 70:235, 1949. 34. Moller, P.: Investigations on the Metabolism of Vitamin B6 , Acta physiol. scandinav. 23:47,:47, 1951. 35. Sarett, H. P.: Effect of Oral Administration of Streptomycin on Urinary Excretion of B Vitamins in Man , J. Nutrition 47:275, 1952. 36. di Raimondo, F.; Angarano, D.; Mannino, N., and Trinchese, L.: Collateral Effects of Antibiotics in the Rat, with Special Reference to Metabolism of Vitamins of the B Complex , Internat. Ztschr. Vitaminforsch. 24:276, 1952. 37. di Raimondo, F.; Angarano, D.; Mannino, N., and Trinchese, L.: Side-Effects of Some Antibiotics in Healthy Subjects and in Patients with Special Reference to Urinary Excretion of Vitamins and of the B Complex , Internat. Ztschr. Vitaminforsch. 24:302, 1952. 38. Boxer, G. E.; Pruss, M. P., and Gordhart, R. S.: Determination of Pyridoxal-5-Phosphoric Acid (B6-PO4) in the Whole Blood and Isolated Leukocytes, to be published. 39. Sarett, H. P.: A Study of the Measurement of 4-Pyridoxic Acid in the Urine , J. Biol. Chem. 189:769, 1951. 40. Mueller, J. F., and Vilter, R. W.: Pyridoxine Deficiency in Human Beings Induced with Desoxypyridoxine , J. Clin. Invest. 29:193, 1950. 41. Snyderman, S. E.; Carretero, R., and Holt, L. E., Jr.: Pyridoxine Deficiency in the Human Being , Fed. Proc. 9:371, 1950. 42. Coursin, D. B.: Convulsive Seizures in Infants with Pyridoxine-Deficient Diet , J. A. M. A. 154:406, 1954. 43. Molony, C. J., and Parmelee, A. H.: Convulsions in Young Infants as a Result of Pyridoxine (Vitamin B6) Deficiency , J. A. M. A. 154: 405, 1954. 44. May, C. D.: Vitamin B6 in Human Nutrition: A Critique and an Object Lesson , Pediatrics 14:269, 1954. 45. Hunt, A. D., Jr.; Stokes, J., Jr.; McCrory, W. W., and Stroud, H. H.: Pyridoxine Dependency: Report of a Case of Intractable Convulsions in an Infant Controlled by Pyridoxine , Pediatrics 13:140, 1954. 46. Greenfield, J. G.: Results of Histological Examination of Rats Suffering from Fits. Addendum to footnote 23. 47. Gellhorn, A., and Jones, L. O.: Pyridoxine Deficient Diet and Desoxypyridoxine in the Therapy of Lymphosarcoma and Acute Leukemia in Man , Blood 4:60, 1949. 48. Reilly, R. H.; Killam, K. F.; Jenney, E. H.; Marshall, W. H.; Taussig, T.; Apter, N. S., and Pfeiffer, C. C.: Convulsant Effects of Isoniazid , J. A. M. A. 152:1317, 1953. 49. Tower, D. B.: Neurochemical Aspects of Pyriodoxine Metabolism and Function, in Symposium on the Role of Some of the Newer Vitamins in Human Metabolism and Nutrition: Proceedings of Nutrition Symposium Held at Vanderbilt University School of Medicine, Nashville, Tenn., Oct. 20-21, 1955, Nutrition Symposium Series No. 12, edited by R. D. Adams et al., New York, National Vitamin Foundation, Inc., 1956, p. 21. 50. Vilter, R. W.; Mueller, J. F.; Glazer, H. S.; Jarrold, T.; Abraham, J.; Thompson, C., and Hawkins, V. R.: The Effect of Vitamin B6 Deficiency Induced by Desoxypyridoxine in Human Beings , J. Lab. & Clin. Med. 42:335, 1953. 51. Biehl, J. P., and Vilter, R. W.: Effect of Isoniazid on Vitamin B6 Metabolism: Its Possible Significance in Producing Isoniazid Neuritis , Proc. Soc. Exper. Biol. & Med. 85:389, 1954. 52. Harris, J. W.; Whittington, R. M.; Weisman, R., Jr., and Horrigan, D. L.: Pyridoxine Responsive Anemia in the Human Adult , Proc. Soc. Exper. Biol. & Med. 91:427, 1956. 53. Wachstein, M., and Gudaitis, A.: Disturbance of Vitamin B6 Metabolism in Pregnancy , J. Lab. & Clin. Med. 40:550, 1952. 54. Wachstein, M., and Gudaitis, A.: Disturbance of Vitamin B6 Metabolism in Pregnancy: III. Abnormal Vitamin B6 Load Test , Am. J. Obst. & Gynec. 66:1207, 1953. 55. Friedman, B. I.; Becker, L.; Thompson, C., and Vilter, R. W.: Vitamin B6 Metabolism in the Post-Partum Period , J. Lab. & Clin. Med. 46: 817, 1955. 56. Schreiner, A. W.; Slinger, W. N.; Hawkins, V. R., and Vilter, R. W.: Seborrheic Dermatitis: A Local Metabolic Defect Involving Pyridoxine , J. Lab. & Clin. Med. 40:121, 1952. 57. Effersøe, H.: The Effect of Topical Application of Pyridoxine Ointment on the Rate of Sebaceous Secretion in Patients with Seborrheic Dermatitis , Acta dermat.-venereol. 34:272, 1954.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1958

References