Abstract It is well known that patients with multiple sclerosis note fluctuations in their symptoms under certain circumstances. For instance, it is generally known among patients that they feel more uncomfortable in heat than in cold. Heat aggravates partly their general condition and partly their neurological symptoms. In addition to an exacerbation of the existing symptoms, heat may even induce new ones, such as the transient visual impairment after a hot bath. This phenomenon has also been observed during muscular exertion and after eating. Some time ago there was in the Department of Neurology of the Copenhagen City Hospital a patient whose syndrome was dominated by such visual complaints. For this reason, we started looking for similar symptoms in other patients with the same disease. Before proceeding to general considerations regarding these visual complaints and their relation to stress, we shall briefly report this patient's history. The patient was a student, References 1. Guthrie7 in 1951. 2. References 4 and 7. 3. References 4, 7, and 8. 4. Blegvad, O.: Die Prognose der excessiven Myopie , Acta ophth. 5:49, 1927.Crossref 5. Elschnig, A.: Refraktionsänderungen bei Diabetes mellitus , Med. Klin. 19:17, 1923. 6. Engel, D.: Reaction of the Cerebral Circulation to Thermal Stimulation of the Limbs , Acta psychiat. et neurol. scandinav. 29:61, 1954.Crossref 7. Fog, T.: Rygmarvens patologiske anatomi ved dissemineret sclerose og dissemineret encephalomyelitis, Thesis, Copenhagen, Ejnar Munksgaards Forlag, 1948. 8. Fog, T.: Topographic Distribution of Plaques in the Spinal Cord in Multiple Sclerosis , Arch. Neurol. & Psychiat. 63:382, 1950. 9. Fog, T.: On the Pathogenesis of Multiple Sclerosis , Acta psychiat. et neurol. scandinav. , (Supp. 74) , pp. 22-31, 1951. 10. Guthrie, T. C.: Visual and Motor Changes in Patients with Multiple Sclerosis: A Result of Induced Changes in Environmental Temperature , A. M. A. Arch. Neurol. & Psychiat. 65:437, 1951. 11. Haarr, M.: Periphlebitis retinæ ved sclerosis multiplex , Oslo, Akademisk Trykningssentral, Blindern, 1951. 12. Putnam, T. J.: Studies in Multiple Sclerosis: IV. "Encephalitis" and Sclerotic Plaques Produced by Venular Obstruction , Arch. Neurol. & Psychiat. 33:929, 1935. 13. Putnam, T. J.: Evidences of Vascular Occlusion in Multiple Sclerosis , Arch. Neurol. & Psychiat. 37:1298, 1937. 14. Putnam, T. J., and Alexander, L.: Disseminated Encephalomyelitis: A Histologic Syndrome Associated with Thrombosis of Small Cerebral Vessels , Arch. Neurol. & Psychiat. 41:1087, 1939.
A.M.A. Archives of Neurology & Psychiatry – American Medical Association
Published: Mar 1, 1955
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