Key PointsQuestionsAmong eyes with vitreous hemorrhage due to proliferative diabetic retinopathy initially treated with aflibercept or vitrectomy with panretinal photocoagulation, what changes occur in visual acuity and other ocular outcomes? FindingsIn this comparative effectiveness study of 205 eyes undergoing treatment, no difference in mean visual acuity over 24 weeks was noted between treatment groups. Results of post hoc analyses show that the vitrectomy group had better visual acuity over 24 weeks of follow-up in the subgroup of eyes with baseline best-corrected visual acuity worse than 20/800. MeaningAflibercept and vitrectomy are viable treatment options for vitreous hemorrhage due to proliferative diabetic retinopathy, and the results of this study may influence treatment decisions when initiating therapy.
JAMA Ophthalmology – American Medical Association
Published: Jul 6, 2021