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Vision Preservation With Neural Stem Cells Derived From Small Molecules

Vision Preservation With Neural Stem Cells Derived From Small Molecules TRANSLATIONAL SCIENCE WITH CLINICAL PROMISE Vision Preservation With Neural Stem Cells Derived From Small Molecules TEM CELLS ARE UNSPECIALIZED CELLS WITH ment of cells will require that they can be amplified and the capacity for unlimited self-renewal. Each banked, that they maintain biological properties stably daughter cell has the capacity to remain a despite frequent passaging, and, ideally, that they ac- stem cell or to differentiate into more spe- quire these properties in the absence of viral vectors. Thus, S cialized, tissue-specific or organ-specific the significance of the work reported by Lu et al is not cells. Human embryonic stem cells (hESCs), derived from that they have used stem cells to rescue the retina in a the inner cell mass of the blastocyst, are pluripotent, which model of human retinitis pigmentosa but that they did means they can form all lineages of the body (ectoderm, so using small molecules to induce the reprogramming mesoderm, and endoderm). Adult cells can be repro- of the cells. grammed to an embryonic state using somatic nuclear Cell-based therapy can preserve and restore vision by cell transfer. (This is the technique that was used to cre- replacing lost cells and/or by paracrine effects that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Vision Preservation With Neural Stem Cells Derived From Small Molecules

JAMA Ophthalmology , Volume 131 (2) – Feb 1, 2013

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/jamaophthalmol.2013.2664
pmid
23307176
Publisher site
See Article on Publisher Site

Abstract

TRANSLATIONAL SCIENCE WITH CLINICAL PROMISE Vision Preservation With Neural Stem Cells Derived From Small Molecules TEM CELLS ARE UNSPECIALIZED CELLS WITH ment of cells will require that they can be amplified and the capacity for unlimited self-renewal. Each banked, that they maintain biological properties stably daughter cell has the capacity to remain a despite frequent passaging, and, ideally, that they ac- stem cell or to differentiate into more spe- quire these properties in the absence of viral vectors. Thus, S cialized, tissue-specific or organ-specific the significance of the work reported by Lu et al is not cells. Human embryonic stem cells (hESCs), derived from that they have used stem cells to rescue the retina in a the inner cell mass of the blastocyst, are pluripotent, which model of human retinitis pigmentosa but that they did means they can form all lineages of the body (ectoderm, so using small molecules to induce the reprogramming mesoderm, and endoderm). Adult cells can be repro- of the cells. grammed to an embryonic state using somatic nuclear Cell-based therapy can preserve and restore vision by cell transfer. (This is the technique that was used to cre- replacing lost cells and/or by paracrine effects that

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Feb 1, 2013

References

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