TRANSLATIONAL SCIENCE WITH CLINICAL PROMISE Vision Preservation With Neural Stem Cells Derived From Small Molecules TEM CELLS ARE UNSPECIALIZED CELLS WITH ment of cells will require that they can be amplified and the capacity for unlimited self-renewal. Each banked, that they maintain biological properties stably daughter cell has the capacity to remain a despite frequent passaging, and, ideally, that they ac- stem cell or to differentiate into more spe- quire these properties in the absence of viral vectors. Thus, S cialized, tissue-specific or organ-specific the significance of the work reported by Lu et al is not cells. Human embryonic stem cells (hESCs), derived from that they have used stem cells to rescue the retina in a the inner cell mass of the blastocyst, are pluripotent, which model of human retinitis pigmentosa but that they did means they can form all lineages of the body (ectoderm, so using small molecules to induce the reprogramming mesoderm, and endoderm). Adult cells can be repro- of the cells. grammed to an embryonic state using somatic nuclear Cell-based therapy can preserve and restore vision by cell transfer. (This is the technique that was used to cre- replacing lost cells and/or by paracrine effects that
JAMA Ophthalmology – American Medical Association
Published: Feb 1, 2013
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