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Vintage Progressive Outer Retinal Necrosis

Vintage Progressive Outer Retinal Necrosis Letters peutically beneficial. These compounds include chemothera- dence that degradation of intraretinal laminin plays a key role. peutic agents and nonselective β-blockers, among dozens of In addition to its distribution in vitreous gel and lens zonules, other examples, and can be safe and effective when dosed in laminin is present in multiple retinal layers, including the a certain therapeutic window. internal limiting membrane, the outer plexiform layer (where We believe the most important question to answer is it localizes to synapses between photoreceptor and bipolar whether ocriplasmin can cause irreversible structural and func- cells), the external limiting membrane, and the interphotore- 2,3 tional alterations in the retina. To draw on 2 comparative ex- ceptor matrix. It has been shown in rat eyes that intravit- tremes, we should ask whether ocriplasmin is analogous to the real ocriplasmin traverses the retina and degrades laminin in effects of a gas bubble after pars plana vitrectomy, which causes the photoreceptor cell layer. Importantly, there are strong a severe but transient and fully reversible decrease in vision, correlations between the specific adverse effects of ocriplas- or more analogous to a toxic agent that causes irreversible struc- min and the anatomical distribution of laminin within http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Vintage Progressive Outer Retinal Necrosis

JAMA Ophthalmology , Volume 133 (2) – Feb 1, 2015

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Publisher
American Medical Association
Copyright
Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/jamaophthalmol.2014.4486
pmid
25393835
Publisher site
See Article on Publisher Site

Abstract

Letters peutically beneficial. These compounds include chemothera- dence that degradation of intraretinal laminin plays a key role. peutic agents and nonselective β-blockers, among dozens of In addition to its distribution in vitreous gel and lens zonules, other examples, and can be safe and effective when dosed in laminin is present in multiple retinal layers, including the a certain therapeutic window. internal limiting membrane, the outer plexiform layer (where We believe the most important question to answer is it localizes to synapses between photoreceptor and bipolar whether ocriplasmin can cause irreversible structural and func- cells), the external limiting membrane, and the interphotore- 2,3 tional alterations in the retina. To draw on 2 comparative ex- ceptor matrix. It has been shown in rat eyes that intravit- tremes, we should ask whether ocriplasmin is analogous to the real ocriplasmin traverses the retina and degrades laminin in effects of a gas bubble after pars plana vitrectomy, which causes the photoreceptor cell layer. Importantly, there are strong a severe but transient and fully reversible decrease in vision, correlations between the specific adverse effects of ocriplas- or more analogous to a toxic agent that causes irreversible struc- min and the anatomical distribution of laminin within

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Feb 1, 2015

References