Abstract In recent studies in this and in other laboratories it has been shown that even though glucose tolerance tests are normal in muscular dystrophy the serum electrolyte responses to acceleration of carbohydrate metabolism often differ from these seen in normal subjects. Thus, Van Bekkum and Querido have reported that the administration of dextrose produced a smaller decrease in the serum inorganic phosphorus of adult patients in the far-advanced stage of muscular dystrophy.1 This was not evident in our series of children with early and late forms of the disorder.2 However, the administration of insulin to members of this same group produced less of a drop in serum inorganic phosphorus, serum potassium, and serum bicarbonate; this was also true when insulin and dextrose were administered in combination.2 In the studies with dextrose or with insulin alone the venous blood-sugar responses were within the range observed in control subjects References 1. Van Bekkum, D. W., and Querido, A.: Inorganic Phosphate Response to Intravenous Glucose Administration in Progressive Muscular Dystrophy , J. Clin. Invest. 32:1061-1065 ( (Nov.) ) 1953.Crossref 2. Danowski, T. S.; Gillespie, H. K.; Egan, T. J.; Mateer, F. M., and Leinberger, M. H.: Muscular Dystrophy: V. Blood Sugar and Serum Electrolytes Following Insulin and Dextrose, Alone or in Combination , A. M. A. J. Dis. Child. , this issue, p. 429. 3. Danowski, T. S.; Bastiani, R. M.; McWilliams, F. D.; Mateer, F. M., and Greenman, L.: Muscular Dystrophy: IV. Endocrine Studies , A. M. A. J. Dis. Child. 91:356-364 ( (April) ) 1956.Crossref 4. Dury, A.: The Effect of Epinephrine and Insulin on the Plasma Potassium Level , Endocrinology 49:663-670 ( (Nov.) ) 1951.Crossref 5. Dury, A.; Holler, J. W., and Smith, C.: The Changes in Plasma Potassium Level after Epinephrine in Normal Human Beings and in Persons with Epilepsy , J. Clin. Invest. 31:440-444 ( (May) ) 1952.Crossref 6. Treadwell, C. R., and Dury, A.: Epinephrine and Insulin Effect on Potassium Mobilization: Relationship of Lipid and Carbohydrate Metabolism , Proc. Soc. Exper. Biol. & Med. 82:727-730 ( (April) ) 1953. 7. Soskin, S.; Levine, R., and Hechter, O.: The Relation Between the Phosphate Changes in Blood and Muscle, Following Dextrose, Insulin and Epinephrin Administration , Am. J. Physiol. 134:40-46 ( (Aug.) ) 1941. 8. Kret, A.: Glucose and Inorganic Phosphate of the Blood , Acta brevia Neerland. physiol., pharmacol., microbiol. 13:79, 1946. 9. D'Silva, J. L.: Action of Adrenaline on the Perfused Liver , J. Physiol. 87:181-188 ( (June) ) 1936. 10. D'Silva, J. L.: Action of Adrenaline on the Serum Potassium , J. Physiol. 90:303-309 ( (Aug.) ) 1937. 11. Keys, A.: The Response of the Plasma Potassium Level in Man to the Administration of Epinephrine , Am. J. Physiol. 121:325-330 ( (Feb.) ) 1938. 12. Brewer, G.; Larson, P. S., and Schroeder, A. R.: On the Effect of Epinephrine on Blood Potassium , Am. J. Physiol. 126:708-712 ( (July) ) 1939. 13. Martin, F. N., Jr.: Comparison of Changes in Serum Glucose, Serum Potassium and Blood Pressure after Epinephrine , Proc. Soc. Exper. Biol. & Med. 59:1-4 ( (May) ) 1945. 14. Elkington, J. St.C, and Goldblatt, M. W.: Effect of Adrenaline in Certain Muscular Disorders , Lancet 2:693-698 ( (Sept. 23) ) 1933. 15. Sutherland, E. W.; Wosilait, W. D., and Rail, T.: Effect of Epinephrine and Glucagon on Activation of Liver Phosphorylase , Fed. Proc. 14:289 ( (March) ) 1955. 16. Cornblath, M.: Effect of Epinephrine, Glucagon and Ephedrine on Phosphorylase Activity in Rabbit Liver Slices , Fed. Proc. 14:430 ( (March) ) 1955. 17. Somogyi, M.: Mechanism of Epinephrine-Hyperglycemia , Endocrinology 49:774-781 ( (Dec.) ) 1951. 18. Van Itallie, T. B.; Morgan, M. C., and Dotti, L. B.: Effect of Glucagon on Peripheral Utilization of Glucose in Man , J. Clin. Endocrinol. 15:28-35 ( (Jan.) ) 1955. 19. Danowski, T. S.; Wirth, P. M.; Leinberger, M. H.; Randall, L. A., and Peters, J. H.: Muscular Dystrophy: III. Serum and Blood Solutes and Other Laboratory Indices , A. M. A. J. Dis. Child. 91:346 (April) 1956. 20. Leonard, S. L.: Effect of Hormones on Muscle Glycogenolysis in Hypophysectomized Animals, Procedings of the Third Medical Conference of the Muscular Dystrophy Association of America, Inc., Oct. 8-9, 1954, pp. 297-302. 21. Milman, A. E.: Metabolism of Glycogen in Experimental Muscular Dystrophy, Proceedings of the Third Medical Conference of the Muscular Dystrophy Association of America, Inc., Oct. 8-9, 1954, pp. 291-296.
A.M.A. Journal of Diseases of Children – American Medical Association
Published: May 1, 1956
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