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Vesiculopustules of the Thighs and Abdomen

Vesiculopustules of the Thighs and Abdomen Abstract REPORT OF A CASE A 31-year-old woman was referred to the dermatology clinic with a 2-month history of a vesiculopustular eruption. The lesions were infrequently pruritic. She had been treated with erythromycin base (PCE), 2% mupirocin ointment (Bactroban), methylprednisolone (Medrol), and intramuscular triamcinolone acetonide (Kenalog), all without appreciable effect. She denied any previous dermatologic problems, systemic symptoms, chemical exposure, or travel. Her medications included oral contraceptives and weekly injections for her allergy.Dermatologic examination revealed discrete erythematous vesicles and pustules involving the anterior aspect of her thighs, lower abdomen, neck, and arms (Figs 1 and 2). No scaling or crusting was observed. The remainder of her skin was normal.A hemogram, reticulocyte count, and chemistry profile all showed normal results. Routine bacterial cultures of intact vesicles revealed no pathogens.Histopathologic analysis showed a subcorneal pustule (Fig 3) filled with numerous neutrophils and serous exudate (Fig 4). The basal cell layer References 1. Sneddon IB, Wilkinson DS. Subcorneal pustular dermatosis . Br J Dermatol. 1956;68:385-394.Crossref 2. Johnson SAM, Cripps DJ. Subcorneal pustular dermatosis in children . Arch Dermatol. 1974;109:73-77.Crossref 3. Sneddon IB, Wilkinson DS. Subcorneal pustular dermatosis . Br J Dermatol. 1979;100:61-68.Crossref 4. Park YK, Park HY, Bang DS, Cho CK. Subcorneal pustular dermatosis treated with phototherapy . Int J Dermatol. 1986;25:124-126.Crossref 5. Kasha EE, Epinette WW. Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) in association with a monoclonal IgA gammopathy: a report and review of the literature . J Am Acad Dermatol. 1988;19:854-858.Crossref 6. Venning VA, Ryan TJ. Subcorneal pustular dermatosis followed by pyoderma gangrenosum . Br J Dermatol. 1986;115:117-118.Crossref 7. Tan RSH. Acute generalized pustular bacterid: an unusual manifestation of leukocytoclastic vasculitis . Br J Dermatol. 1974;91:209-215.Crossref 8. Saulsbury FT, Kesler RW. Subcorneal pustular dermatosis and systemic lupus erythematosus . Int J Dermatol. 1984;23:63-64.Crossref 9. Olsen TG, Wright RC, Lester AI. Subcorneal pustular dermatosis and crippling arthritis . Arch Dermatol. 1979;115:185-188.Crossref 10. Krogh HK, Tönder O. Subcorneal pustular dermatosis: pathogenetic aspects . Br J Dermatol. 1970;83:429-434.Crossref 11. Wallach D, Cottenot F, Pelbois G, Cavelier B, Didierjean L, Saurat HJ. Subcorneal pustular dermatosis and monoclonal IgA . Br J Dermatol. 1982;107:229-234.Crossref 12. Sanchez N, Ackerman AB. Subcorneal pustular dermatosis: a variant of pustular psoriasis . Acta Derm Venereol Suppl (Stockh) . 1979;59:147-151. 13. Lever WF, Schaumburg-Lever G. Histopathology of the Skin . Philadelphia, Pa: JB Lippincott; 1983:125-127. 14. Tagami H, Iwatsuki K, Iwase Y, Yamada M. Subcorneal pustular dermatosis with vesiculo-bullous eruption: demonstration of subcorneal IgA deposits and a leukocyte chemotactic factor . Br J Dermatol. 1983;109:581-587.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Vesiculopustules of the Thighs and Abdomen

Archives of Dermatology , Volume 127 (10) – Oct 1, 1991

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680090135019
Publisher site
See Article on Publisher Site

Abstract

Abstract REPORT OF A CASE A 31-year-old woman was referred to the dermatology clinic with a 2-month history of a vesiculopustular eruption. The lesions were infrequently pruritic. She had been treated with erythromycin base (PCE), 2% mupirocin ointment (Bactroban), methylprednisolone (Medrol), and intramuscular triamcinolone acetonide (Kenalog), all without appreciable effect. She denied any previous dermatologic problems, systemic symptoms, chemical exposure, or travel. Her medications included oral contraceptives and weekly injections for her allergy.Dermatologic examination revealed discrete erythematous vesicles and pustules involving the anterior aspect of her thighs, lower abdomen, neck, and arms (Figs 1 and 2). No scaling or crusting was observed. The remainder of her skin was normal.A hemogram, reticulocyte count, and chemistry profile all showed normal results. Routine bacterial cultures of intact vesicles revealed no pathogens.Histopathologic analysis showed a subcorneal pustule (Fig 3) filled with numerous neutrophils and serous exudate (Fig 4). The basal cell layer References 1. Sneddon IB, Wilkinson DS. Subcorneal pustular dermatosis . Br J Dermatol. 1956;68:385-394.Crossref 2. Johnson SAM, Cripps DJ. Subcorneal pustular dermatosis in children . Arch Dermatol. 1974;109:73-77.Crossref 3. Sneddon IB, Wilkinson DS. Subcorneal pustular dermatosis . Br J Dermatol. 1979;100:61-68.Crossref 4. Park YK, Park HY, Bang DS, Cho CK. Subcorneal pustular dermatosis treated with phototherapy . Int J Dermatol. 1986;25:124-126.Crossref 5. Kasha EE, Epinette WW. Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) in association with a monoclonal IgA gammopathy: a report and review of the literature . J Am Acad Dermatol. 1988;19:854-858.Crossref 6. Venning VA, Ryan TJ. Subcorneal pustular dermatosis followed by pyoderma gangrenosum . Br J Dermatol. 1986;115:117-118.Crossref 7. Tan RSH. Acute generalized pustular bacterid: an unusual manifestation of leukocytoclastic vasculitis . Br J Dermatol. 1974;91:209-215.Crossref 8. Saulsbury FT, Kesler RW. Subcorneal pustular dermatosis and systemic lupus erythematosus . Int J Dermatol. 1984;23:63-64.Crossref 9. Olsen TG, Wright RC, Lester AI. Subcorneal pustular dermatosis and crippling arthritis . Arch Dermatol. 1979;115:185-188.Crossref 10. Krogh HK, Tönder O. Subcorneal pustular dermatosis: pathogenetic aspects . Br J Dermatol. 1970;83:429-434.Crossref 11. Wallach D, Cottenot F, Pelbois G, Cavelier B, Didierjean L, Saurat HJ. Subcorneal pustular dermatosis and monoclonal IgA . Br J Dermatol. 1982;107:229-234.Crossref 12. Sanchez N, Ackerman AB. Subcorneal pustular dermatosis: a variant of pustular psoriasis . Acta Derm Venereol Suppl (Stockh) . 1979;59:147-151. 13. Lever WF, Schaumburg-Lever G. Histopathology of the Skin . Philadelphia, Pa: JB Lippincott; 1983:125-127. 14. Tagami H, Iwatsuki K, Iwase Y, Yamada M. Subcorneal pustular dermatosis with vesiculo-bullous eruption: demonstration of subcorneal IgA deposits and a leukocyte chemotactic factor . Br J Dermatol. 1983;109:581-587.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1991

References