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Very High Dose Fluphenazine Decanoate: A Controlled Trial in Chronic Schizophrenia

Very High Dose Fluphenazine Decanoate: A Controlled Trial in Chronic Schizophrenia Abstract • In a double-blind trial of six months' duration, a very high dose (VHD) regimen of fluphenazine decanoate (250 mg weekly) was compared with a standard dose (SD) regimen (12.5 mg weekly) in 50 chronic schizophrenic patients. The rating scales used included the Brief Psychiatric Rating Scale1 and the Wing Ward Behavior Scale.2 Both treatment groups improved during the trial, but there was no significant difference between them. The VHD regimen, however, exerted better control of the psychosis in that it had fewer patient dropouts and fewer "additional treatments" prescribed. Some of the patients receiving standard doses were probably not receiving adequate antipsychotic drug dosage. No predictors of clinical response could be defined. Extrapyramidal side effects were not significantly higher in the VHD group. References 1. Overall JE, Gorham DR: The brief psychiatric rating scale . Psychol Res 10:799-812, 1962. 2. Wing JK: A simple and reliable subclassification of chronic schizophrenia . J Ment Sci 107:862-875, 1961. 3. Prien RF, Cole JO: High-dose chlorpromazine therapy in chronic schizophrenia . Arch Gen Psychiatry 18:482-495, 1968.Crossref 4. Prien RF, Levine J, Cole JO: High-dose trifluoperazine therapy in chronic schizophrenia . Am J Psychiatry 126:305-313, 1969. 5. Clark ML, Ramsey HR, Rahhal DK, et al: Chlorpromazine in chronic schizophrenia . Arch Gen Psychiatry 27:479-483, 1972.Crossref 6. Rifkin A, Quitkin F, Carillo C, et al: Very high-dosage fluphenazine for nonchronic treatment-refractory patients . Arch Gen Psychiatry 25:398-403, 1971.Crossref 7. Polvan N: Fluphenazine hydrochloride and enanthate in the management of chronic psychosis . Dis Nerv Syst 31( (suppl) ):48-49, 1970. 8. McClelland HA, Blessed G, Bhate S, et al: The abrupt withdrawal of antiparkinson drugs in schizophrenic patients . Br J Psychiatry 124:151-159, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Very High Dose Fluphenazine Decanoate: A Controlled Trial in Chronic Schizophrenia

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1976.01770120039003
Publisher site
See Article on Publisher Site

Abstract

Abstract • In a double-blind trial of six months' duration, a very high dose (VHD) regimen of fluphenazine decanoate (250 mg weekly) was compared with a standard dose (SD) regimen (12.5 mg weekly) in 50 chronic schizophrenic patients. The rating scales used included the Brief Psychiatric Rating Scale1 and the Wing Ward Behavior Scale.2 Both treatment groups improved during the trial, but there was no significant difference between them. The VHD regimen, however, exerted better control of the psychosis in that it had fewer patient dropouts and fewer "additional treatments" prescribed. Some of the patients receiving standard doses were probably not receiving adequate antipsychotic drug dosage. No predictors of clinical response could be defined. Extrapyramidal side effects were not significantly higher in the VHD group. References 1. Overall JE, Gorham DR: The brief psychiatric rating scale . Psychol Res 10:799-812, 1962. 2. Wing JK: A simple and reliable subclassification of chronic schizophrenia . J Ment Sci 107:862-875, 1961. 3. Prien RF, Cole JO: High-dose chlorpromazine therapy in chronic schizophrenia . Arch Gen Psychiatry 18:482-495, 1968.Crossref 4. Prien RF, Levine J, Cole JO: High-dose trifluoperazine therapy in chronic schizophrenia . Am J Psychiatry 126:305-313, 1969. 5. Clark ML, Ramsey HR, Rahhal DK, et al: Chlorpromazine in chronic schizophrenia . Arch Gen Psychiatry 27:479-483, 1972.Crossref 6. Rifkin A, Quitkin F, Carillo C, et al: Very high-dosage fluphenazine for nonchronic treatment-refractory patients . Arch Gen Psychiatry 25:398-403, 1971.Crossref 7. Polvan N: Fluphenazine hydrochloride and enanthate in the management of chronic psychosis . Dis Nerv Syst 31( (suppl) ):48-49, 1970. 8. McClelland HA, Blessed G, Bhate S, et al: The abrupt withdrawal of antiparkinson drugs in schizophrenic patients . Br J Psychiatry 124:151-159, 1974.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Dec 1, 1976

References