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Verapamil vs Quinine in Recumbent Nocturnal Leg Cramps in the Elderly

Verapamil vs Quinine in Recumbent Nocturnal Leg Cramps in the Elderly Abstract • In an open-labeled trial with eight elderly patients (aged 62 to 87 years) suffering from nocturnal leg cramps refractory to treatment with quinine sulfate, we ruled out other active disease processes and substituted verapamil hydrochloride therapy (120 mg at bedtime). Response to treatment was assessed by biweekly observations by the primary care physician and nightly by the research registered nurse for the entire duration of the trial, lasting eight weeks. Observations made and clinical conditions reported were indicative of improvement and disappearance of cramping when therapy was changed from quinine to verapamil. This noteworthy improvement in patients with recumbent nocturnal leg cramps is an important finding and merits further investigation. (Arch Intern Med 1988;148:1969-1970) References 1. Nocturnal or recumbency muscle cramps. Med Lett Drugs Ther 1966;20:83-84. 2. Bradley WG, Adams RD: Other major muscle syndromes , in Petersdorf RG, Adams RD, Braunwald E, et al (eds): Harrison's Principles of Internal Medicine , ed 10. New York, McGraw-Hill International Book Co, 1983, pp 2198-2199. 3. Physicians' Desk Reference , ed 41. Oradell, NJ, Medical Economics Books, 1987, p 1363. 4. Webster LTJr: Drugs used in the chemotherapy of protozoal infections , in Gilman AG, Goodman LS, Gilman A (eds): Goodman and Gilman's The Pharmacological Basis of Therapeutics , ed 7. New York, Macmillan Publishing Co Inc, 1985, p 1044. 5. Quinine for 'night cramps.' Med Lett Drugs Ther 1986;28:110. 6. Fowler AW: Relief of cramps. Lancet 1973;1:99.Crossref 7. Fowler AW: Quinine for night cramps. Br Med J 1985;291:281.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Verapamil vs Quinine in Recumbent Nocturnal Leg Cramps in the Elderly

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1988.00380090055015
Publisher site
See Article on Publisher Site

Abstract

Abstract • In an open-labeled trial with eight elderly patients (aged 62 to 87 years) suffering from nocturnal leg cramps refractory to treatment with quinine sulfate, we ruled out other active disease processes and substituted verapamil hydrochloride therapy (120 mg at bedtime). Response to treatment was assessed by biweekly observations by the primary care physician and nightly by the research registered nurse for the entire duration of the trial, lasting eight weeks. Observations made and clinical conditions reported were indicative of improvement and disappearance of cramping when therapy was changed from quinine to verapamil. This noteworthy improvement in patients with recumbent nocturnal leg cramps is an important finding and merits further investigation. (Arch Intern Med 1988;148:1969-1970) References 1. Nocturnal or recumbency muscle cramps. Med Lett Drugs Ther 1966;20:83-84. 2. Bradley WG, Adams RD: Other major muscle syndromes , in Petersdorf RG, Adams RD, Braunwald E, et al (eds): Harrison's Principles of Internal Medicine , ed 10. New York, McGraw-Hill International Book Co, 1983, pp 2198-2199. 3. Physicians' Desk Reference , ed 41. Oradell, NJ, Medical Economics Books, 1987, p 1363. 4. Webster LTJr: Drugs used in the chemotherapy of protozoal infections , in Gilman AG, Goodman LS, Gilman A (eds): Goodman and Gilman's The Pharmacological Basis of Therapeutics , ed 7. New York, Macmillan Publishing Co Inc, 1985, p 1044. 5. Quinine for 'night cramps.' Med Lett Drugs Ther 1986;28:110. 6. Fowler AW: Relief of cramps. Lancet 1973;1:99.Crossref 7. Fowler AW: Quinine for night cramps. Br Med J 1985;291:281.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1988

References