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vCJD and Transfusion Risk

vCJD and Transfusion Risk Researchers in England and Scotland have identified what they say may be the first case of possible transmission through a blood transfusion of variant Creutzfeldt-Jakob disease (vCJD), the human version of mad cow disease (Lancet. 2004;363:417-421). The researchers identified 48 individuals who received a blood component from donors who later developed vCJD; one of the 48 subsequently developed symptoms of the illness. Although it isn't possible to rule out that the transfusion recipient contracted vCJD from eating infected meat, the researchers calculated that the "chance of observing a case of vCJD in a recipient in the absence of transfusion-transmitted infection is about 1 in 15 000 to 1 in 30 000." The authors added that "although the epidemic of vCJD presently seems to be in decline, a proportion of the UK population could be incubating vCJD and acting as blood donors." http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

vCJD and Transfusion Risk

JAMA , Volume 291 (11) – Mar 17, 2004

vCJD and Transfusion Risk

Abstract

Researchers in England and Scotland have identified what they say may be the first case of possible transmission through a blood transfusion of variant Creutzfeldt-Jakob disease (vCJD), the human version of mad cow disease (Lancet. 2004;363:417-421). The researchers identified 48 individuals who received a blood component from donors who later developed vCJD; one of the 48 subsequently developed symptoms of the illness. Although it isn't possible to rule out that the transfusion...
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Publisher
American Medical Association
Copyright
Copyright © 2004 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.291.11.1313-c
Publisher site
See Article on Publisher Site

Abstract

Researchers in England and Scotland have identified what they say may be the first case of possible transmission through a blood transfusion of variant Creutzfeldt-Jakob disease (vCJD), the human version of mad cow disease (Lancet. 2004;363:417-421). The researchers identified 48 individuals who received a blood component from donors who later developed vCJD; one of the 48 subsequently developed symptoms of the illness. Although it isn't possible to rule out that the transfusion recipient contracted vCJD from eating infected meat, the researchers calculated that the "chance of observing a case of vCJD in a recipient in the absence of transfusion-transmitted infection is about 1 in 15 000 to 1 in 30 000." The authors added that "although the epidemic of vCJD presently seems to be in decline, a proportion of the UK population could be incubating vCJD and acting as blood donors."

Journal

JAMAAmerican Medical Association

Published: Mar 17, 2004

Keywords: transfusion,creutzfeldt-jakob disease, variant

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