Abstract Since the publication in 1882 of Raynaud's1 original description entitled "Observations on Local Asphyxia and Symmetrical Gangrene" there have been numerous factors reported as causal in this syndrome. Regardless of the etiology, Raynaud knew that the condition which he described was more prevalent in nervous women, a fact obtaining today and suggesting cortical or subcortical influence. We propose to show that local asphyxia or abnormal vasoconstriction resulting in syndromes analogous to that of Raynaud may develop from stimuli arising at any level from the cerebral cortex down to the peripheral vessels themselves. REPORT OF CASES Case 1. —F. W., a girl, aged 15, entered the University Hospital on Sept. 16, 1928, with the chief complaint of "difficulty in seeing." The mother stated that after the age of 12 this child had not developed physically as had her other child. The girl had never menstruated. The intellect had always been References 1. Raynaud, M.: Local Asphyxia and Symmetrical Gangrene of the Extremities , translated by Thomas Barlow in Selected Monographs, London, New Sydenham Society, 1888. 2. Bucy, P. C.: Vasomotor Changes Associated with Paralysis of Cerebral Origin , Arch. Neurol. & Psychiat. 33:30 ( (Jan.) ) 1935. 3. Penfield, W.: Diencephalic Autonomic Epilepsy , Arch. Neurol. & Psychiat. 22:358 ( (Aug.) ) 1929. 4. Kuntz, Albert: Personal communication. 5. Bennett, T. I., and Poulton, E. P.: Raynaud's Disease Associated with Cancer of the Stomach , Am. J. M. Sc. 176:657 ( (Nov.) ) 1928. 6. Kennard, M. A.: Vasomotor Representation in the Cerebral Cortex , Science 79:348 ( (April 13) ) 1934. 7. Langworthy, O. R., and Richter, C. P.: The Influence of Efferent Cerebral Pathways upon the Sympathetic Nervous System , Brain 53:178, 1930. 8. Zenner, P., and Kramer, S. P.: Operation for Brain Tumor, with the Hitherto Unrecognized Circulation Phenomena , New York M. J. 90:651, 1909. 9. Osler, W., and McCrae, T.: Modern Medicine , Philadelphia, Lea & Febiger, 1928, vol. 5, p. 723. 10. Fox, C.: On Two Cases of Raynaud's Disease , Tr. Clin. Soc. London 18:300, 1884-1885. 11. Clymer, M.: Lectures on the Palsies and Kindred Disorders of the Nervous System , M. Rec. 5:145 ( (May 16) ) 1870. 12. Maxwell, S. S.: A Case of Voluntary Erection of the Human Hair and Production of Cutis Anserina , Am. J. Physiol. 7:369 ( (July 1) ) 1902. 13. Whitfield, A.: Some Points in the Etiology of Skin Diseases , Lancet 2:168 ( (July 23) ) 1921. 14. Angell, J. R., and Thompson, H. B.: Organic Processes and Consciousness , Psychol. Rev. 6:32, 1899. 15. Shepard, J. E.: Organic Changes and Feeling , Am. J. Psychol. 17:522, 1906. 16. Coller, F. A., and Maddock, W. G.: Personal communication. 17. Camp, Carl: Personal communication. 18. Mitchell, Weir: Unilateral Swelling of Hysterical Hemiplegia , Am. J. M. Sc. 88:94 ( (July) ) 1884. 19. Adson, A. W., and Brown, G. E.: Physiologic Effects of Thoracic and of Lumbar Sympathetic Ganglionectomy or Section of the Trunk , Arch. Neurol. & Psychiat. 22:322 ( (Aug.) ) 1929. 20. Lewis, T., and Landis, E. M.: Some Physiological Effects of Sympathetic Ganglionectomy in the Human Being and Its Effect in a Case of Raynaud's Malady , Heart 15:151, 1930. 21. Lewis, T.: Personal communication. 22. Gaskell, W. H.: On the Innervation of the Heart, with Especial Reference to the Heart of the Tortoise , J. Physiol. 4:43, 1883. 23. Alvarez, W. C.: The Mechanics of the Digestive Tract , New York, Paul B. Hoeber, Inc., 1922. 24. Lake, N. C.: Observations upon the Growth of Tissues in Vitro Relating to the Origin of the Heart Beat , J. Physiol. 50:364 ( (Sept.) ) 1916. 25. Tigerstedt. R.: Die Physiologie des Kreislaufes , ed. 2, Berlin, W. de Gruyter & Co., 1922, vol. 3, p. 51.
Archives of Neurology & Psychiatry – American Medical Association
Published: Jan 1, 1936
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