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G. Andrews, R. Kelly (1932)
TREATMENT OF VASCULAR NEVI BY INJECTION OF SCLEROSING SOLUTIONSArchives of Dermatology, 26
Chiefly because of their cosmetic importance but also because of their hemorrhagic annoyance and occasional invasive and metastasizing propensity, vascular nevi should be eradicated early. There are two types commonly encountered in pediatric practice and readily amenable to treatment, the hemangioma cavernosum or strawberry birthmark, and the hemangioma hypertrophicum or hemangio-endothelionia. The hemangioma cavernosum is a mass of convoluted arterioles and venules with many cystic dilatations and sacculations lined by a single layer of capillary endothelium filled with serum or blood. There is little connective tissue. The lesions may be flat or elevated above the adjacent skin or mucous membrane area. They may involve either the skin or subcutaneous tissue or both. Both skin and mucous membrane may be involved at the mucocutaneous junctions. When superficial, they are a brilliant scarlet; if deeply subcutaneous, blue. The surface is usually soft and papillomatous. The mass is spongy and, when firmly compressed,
JAMA – American Medical Association
Published: May 14, 1938
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