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VARIATIONS IN THE TOXICITY OF CHLOROFORM FOR ANESTHESIA

VARIATIONS IN THE TOXICITY OF CHLOROFORM FOR ANESTHESIA Abstract In considering the toxicity of chloroform it is necessary to recall that a number of chemical processes are involved in its manufacture and that, in the various processes, a considerable number of chemical substances interact to give chloroform as one of the main products. Other products are formed, however, or remain from the mother substances which are used in the manufacturing process. The chloroform itself, of course, does not differ whether it be derived from acetone,1 alcohol, methane, carbon tetrachlorid1 or chloral, but there exist on the market many grades of chloroform, more or less contaminated with by-products of manufacture, in addition to the very best anesthetic grades freed from these products by purification, all of which are known under the general term "chloroform." Even chloroform of the anesthetic grade, however, is not pure CHCl3 but contains in addition a small amount of References 1. The most important sources of chloroform. 2. Baskerville and Hamor : Jour. Indust. and Engin. Chem. , 1912, iv, 212.Crossref 3. Fiegel and Meier : Biochem. Ztschr. , 1906, i, 316. 4. Schafer and Scharlieb : Jour. Physiol. Proc. , 1903, xxix, 17. 5. Embley and Martin: Jour. Physiol. , 1905, xxxii, 147. 6. Waller: Nature , 1907, lxxvi, 402. 7. Tunnicliffe: Pharm. Jour. , xviii, 315. 8. Lehmann: Arch. f. Hyg. , 1903, xlvi, 322. 9. Lee: Liverpool Med. Chir. Jour. , 1895, xv, 412. 10. Buxton: Brit. Med. Jour. , 1912, i, 582.Crossref 11. Squibb & Sons, Parke, Davis & Co., Mallinckrodt Chemical Works, and Albany Chemical Company. 12. It seems advisable to eliminate these figures in estimating the toxicity of a given chloroform as this is not nearly so important as the fact of death itself in measuring toxicity. These figures have been introduced into this and a later table merely to show the lack of relationship between them. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

VARIATIONS IN THE TOXICITY OF CHLOROFORM FOR ANESTHESIA

Archives of Internal Medicine , Volume XV (6) – Jun 1, 1915

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Publisher
American Medical Association
Copyright
Copyright © 1915 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1915.00070250002001
Publisher site
See Article on Publisher Site

Abstract

Abstract In considering the toxicity of chloroform it is necessary to recall that a number of chemical processes are involved in its manufacture and that, in the various processes, a considerable number of chemical substances interact to give chloroform as one of the main products. Other products are formed, however, or remain from the mother substances which are used in the manufacturing process. The chloroform itself, of course, does not differ whether it be derived from acetone,1 alcohol, methane, carbon tetrachlorid1 or chloral, but there exist on the market many grades of chloroform, more or less contaminated with by-products of manufacture, in addition to the very best anesthetic grades freed from these products by purification, all of which are known under the general term "chloroform." Even chloroform of the anesthetic grade, however, is not pure CHCl3 but contains in addition a small amount of References 1. The most important sources of chloroform. 2. Baskerville and Hamor : Jour. Indust. and Engin. Chem. , 1912, iv, 212.Crossref 3. Fiegel and Meier : Biochem. Ztschr. , 1906, i, 316. 4. Schafer and Scharlieb : Jour. Physiol. Proc. , 1903, xxix, 17. 5. Embley and Martin: Jour. Physiol. , 1905, xxxii, 147. 6. Waller: Nature , 1907, lxxvi, 402. 7. Tunnicliffe: Pharm. Jour. , xviii, 315. 8. Lehmann: Arch. f. Hyg. , 1903, xlvi, 322. 9. Lee: Liverpool Med. Chir. Jour. , 1895, xv, 412. 10. Buxton: Brit. Med. Jour. , 1912, i, 582.Crossref 11. Squibb & Sons, Parke, Davis & Co., Mallinckrodt Chemical Works, and Albany Chemical Company. 12. It seems advisable to eliminate these figures in estimating the toxicity of a given chloroform as this is not nearly so important as the fact of death itself in measuring toxicity. These figures have been introduced into this and a later table merely to show the lack of relationship between them.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 1, 1915

References

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