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Variations in the Plasma Fibrinogen During the Course of Multiple Sclerosis

Variations in the Plasma Fibrinogen During the Course of Multiple Sclerosis Abstract The purpose of this work is to assess the values of the plasma fibrinogen found during the course of multiple sclerosis. On the basis of pathological-anatomical and experimental investigations, Putnam * was the first to advance the theory that in the case of multiple sclerosis thrombi are formed in the small veins of the central nervous system and consequently cause the formation of the characteristic plaques. Broman4 and Haarr,† on the basis of pathological-anatomical investigations, defined multiple sclerosis as a periphlebitis; however, they were unable to demonstrate coagulation thrombi in plaques in patients with the disease. Through his investigations, Fog5 found that in this disease the plaques of the spinal cord occur in relation to the veins. It is often difficult to distinguish between the acute signs of this disease and those of vascular attacks; moreover, external factors which increase the coagulability of the blood seem to aggravate multiple References 1. References 1, 2, and 3. 2. Haarr, M.: Changes of the Retinal Veins as an Early Sign of Disseminated Sclerosis, read at the Fourth International Neurological Congress , Paris, 1949. 3. References 7 to 9. 4. References 11 and 12. 5. References 14 through 17. 6. References 18 through 20. 7. References 21 and 22. 8. References 22 and 25. 9. References 7, 8, and 9. 10. Putnam, T. J.: Studies in Multiple Sclerosis: Similarities Between Some Forms of "Encephalomyelitis" and Multiple Sclerosis , Arch. Neurol. & Psychiat. 35:1289, 1936. 11. Putnam, T. J., and Adler, A.: Vascular Architecture of the Lesions of Multiple Sclerosis , Arch. Neurol. & Psychiat. 38:1, 1937. 12. Putnam, T. J.: Evidences of Vascular Occlusion in Multiple Sclerosis and "Encephalomyelitis," Arch. Neurol. & Psychiat. 37:1298, 1937. 13. Broman, T.: Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions , Copenhagen, Ejnar Munksgaards Forlag, 1950. 14. Fog, T.: Pathological Anatomy of the Spinal Cord in Disseminated Sclerosis , Thesis for the M.D. degree, Copenhagen, Ejnar Munksgaards Forlag, 1948. 15. Simon, B., and Solomon, P.: Multiple Sclerosis: Effect of Typhoid Vaccine and of Epinephrine on Coagulation of the Blood , Arch. Neurol. & Psychiat. 34:1286, 1935. 16. Copley, A., and Houlihan, R.: Studies on Platelets: VII. Isolation of Platelets from Human and Dog Blood, Special Issue, No. 1, pp. 170-181, 1947. 17. Hirsch, E.; Favre-Gilly, J., and Dameshek, W.: Thrombopathic Thrombocytopenia , Blood 5:568, 1950. 18. Singer, K.; Bornstein, F., and Wile, S.: Thrombotic Thrombocytopenic Purpura , Blood 2: 542, 1947. 19. Roskam, J.: Rôle des globulins (plaquettes de Bizzozero) en physiologie normale et pathologique , Compt. rend. Soc. biol. 95:29, 1926. 20. Putnam, T. J.: Studies in Multiple Sclerosis: VIII. Etiologic Factors in Multiple Sclerosis , Ann. Int. Med. 9:854, 1936. 21. Putnam, T. J.: Lesions of "Encephalomyelitis" and Multiple Sclerosis , J. A. M. A. 108:1477, 1937. 22. Huszak, I., and Szák, J.: Data on the Pathology of Disseminated Sclerosis , Acta med. scandinav. 138:57, 1950. 23. Ernstene, A.: Erythrocyte Sedimentation, Plasma Fibrinogen and Leucocytosis as Indices of Rheumatic Infection , Am. J. M. Sc. 180:12, 1930. 24. Fahraeus, R.: The Suspension-Stability of the Blood , Acta med. scandinav. 55:3, 1921. 25. Gram, H. C.: Studies on the Fibrin Content in Human Blood and Plasma and Some Allied Problems , Copenhagen, Hasselbalch, 1921. 26. Moen, J., and Reimann, H.: Plasma Protein Changes and Suspension Stability of the Blood in Lobar Pneumonia , J. Clin. Invest. 12: 589, 1933. 27. Greisheimer, E.; Johnson, O., and Ryan, M.: Relationship Between Sedimentation Index and Fibrin Content in Relatively Normal Individuals , Am. J. M. Sc. 177:816, 1929. 28. Greisheimer, E.; Worwick, M., and Walton, M.: Relationship Between Fibrin Content and Sedimentation Index in Orthopedic Cases , Am. J. Dis. Child. 37:953, 1929. 29. Lucia, S.; Blumberg, T.; Brown, J., and Gospe, S.: Relation Between the Suspension Stability of Erythrocytes and Various Constituents of Pathologic Human Blood , Am. J. M. Sc. 192:179, 1936. 30. Wuhrmann, F., and Wunderly, C.: Die Blutweisskörper des Menschen , Basel, Benno Schwabe, 1947. 31. Ries, W.: Blutkörperchensenkung und Fibrin , Ztschr. ges. inn. Med. 7:415, 1952. 32. Persson, I.: Fibrinogen Content of Plasma in Disseminated Sclerosis , Nord. med. 47:310, 1952. 33. Westergren, A.: Studies of the Suspension Stability of the Blood in Pulmonary Tuberculosis , Acta med. scandinav. 54:247, 1921. 34. Ham, T., and Curtis, F.: Plasma Fibrinogen Response in Man , Medicine 17:413, 1938. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Variations in the Plasma Fibrinogen During the Course of Multiple Sclerosis

A.M.A. Archives of Neurology & Psychiatry , Volume 74 (1) – Jul 1, 1955

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1955.02330130019004
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Abstract

Abstract The purpose of this work is to assess the values of the plasma fibrinogen found during the course of multiple sclerosis. On the basis of pathological-anatomical and experimental investigations, Putnam * was the first to advance the theory that in the case of multiple sclerosis thrombi are formed in the small veins of the central nervous system and consequently cause the formation of the characteristic plaques. Broman4 and Haarr,† on the basis of pathological-anatomical investigations, defined multiple sclerosis as a periphlebitis; however, they were unable to demonstrate coagulation thrombi in plaques in patients with the disease. Through his investigations, Fog5 found that in this disease the plaques of the spinal cord occur in relation to the veins. It is often difficult to distinguish between the acute signs of this disease and those of vascular attacks; moreover, external factors which increase the coagulability of the blood seem to aggravate multiple References 1. References 1, 2, and 3. 2. Haarr, M.: Changes of the Retinal Veins as an Early Sign of Disseminated Sclerosis, read at the Fourth International Neurological Congress , Paris, 1949. 3. References 7 to 9. 4. References 11 and 12. 5. References 14 through 17. 6. References 18 through 20. 7. References 21 and 22. 8. References 22 and 25. 9. References 7, 8, and 9. 10. Putnam, T. J.: Studies in Multiple Sclerosis: Similarities Between Some Forms of "Encephalomyelitis" and Multiple Sclerosis , Arch. Neurol. & Psychiat. 35:1289, 1936. 11. Putnam, T. J., and Adler, A.: Vascular Architecture of the Lesions of Multiple Sclerosis , Arch. Neurol. & Psychiat. 38:1, 1937. 12. Putnam, T. J.: Evidences of Vascular Occlusion in Multiple Sclerosis and "Encephalomyelitis," Arch. Neurol. & Psychiat. 37:1298, 1937. 13. Broman, T.: Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions , Copenhagen, Ejnar Munksgaards Forlag, 1950. 14. Fog, T.: Pathological Anatomy of the Spinal Cord in Disseminated Sclerosis , Thesis for the M.D. degree, Copenhagen, Ejnar Munksgaards Forlag, 1948. 15. Simon, B., and Solomon, P.: Multiple Sclerosis: Effect of Typhoid Vaccine and of Epinephrine on Coagulation of the Blood , Arch. Neurol. & Psychiat. 34:1286, 1935. 16. Copley, A., and Houlihan, R.: Studies on Platelets: VII. Isolation of Platelets from Human and Dog Blood, Special Issue, No. 1, pp. 170-181, 1947. 17. Hirsch, E.; Favre-Gilly, J., and Dameshek, W.: Thrombopathic Thrombocytopenia , Blood 5:568, 1950. 18. Singer, K.; Bornstein, F., and Wile, S.: Thrombotic Thrombocytopenic Purpura , Blood 2: 542, 1947. 19. Roskam, J.: Rôle des globulins (plaquettes de Bizzozero) en physiologie normale et pathologique , Compt. rend. Soc. biol. 95:29, 1926. 20. Putnam, T. J.: Studies in Multiple Sclerosis: VIII. Etiologic Factors in Multiple Sclerosis , Ann. Int. Med. 9:854, 1936. 21. Putnam, T. J.: Lesions of "Encephalomyelitis" and Multiple Sclerosis , J. A. M. A. 108:1477, 1937. 22. Huszak, I., and Szák, J.: Data on the Pathology of Disseminated Sclerosis , Acta med. scandinav. 138:57, 1950. 23. Ernstene, A.: Erythrocyte Sedimentation, Plasma Fibrinogen and Leucocytosis as Indices of Rheumatic Infection , Am. J. M. Sc. 180:12, 1930. 24. Fahraeus, R.: The Suspension-Stability of the Blood , Acta med. scandinav. 55:3, 1921. 25. Gram, H. C.: Studies on the Fibrin Content in Human Blood and Plasma and Some Allied Problems , Copenhagen, Hasselbalch, 1921. 26. Moen, J., and Reimann, H.: Plasma Protein Changes and Suspension Stability of the Blood in Lobar Pneumonia , J. Clin. Invest. 12: 589, 1933. 27. Greisheimer, E.; Johnson, O., and Ryan, M.: Relationship Between Sedimentation Index and Fibrin Content in Relatively Normal Individuals , Am. J. M. Sc. 177:816, 1929. 28. Greisheimer, E.; Worwick, M., and Walton, M.: Relationship Between Fibrin Content and Sedimentation Index in Orthopedic Cases , Am. J. Dis. Child. 37:953, 1929. 29. Lucia, S.; Blumberg, T.; Brown, J., and Gospe, S.: Relation Between the Suspension Stability of Erythrocytes and Various Constituents of Pathologic Human Blood , Am. J. M. Sc. 192:179, 1936. 30. Wuhrmann, F., and Wunderly, C.: Die Blutweisskörper des Menschen , Basel, Benno Schwabe, 1947. 31. Ries, W.: Blutkörperchensenkung und Fibrin , Ztschr. ges. inn. Med. 7:415, 1952. 32. Persson, I.: Fibrinogen Content of Plasma in Disseminated Sclerosis , Nord. med. 47:310, 1952. 33. Westergren, A.: Studies of the Suspension Stability of the Blood in Pulmonary Tuberculosis , Acta med. scandinav. 54:247, 1921. 34. Ham, T., and Curtis, F.: Plasma Fibrinogen Response in Man , Medicine 17:413, 1938.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jul 1, 1955

References