Abstract In 1935 one of us (C. A. E.) and associates1 described a new procedure for examination of the olfactory sense by the blast injection and stream injection of odorous substances into the nasal passages. The method of blast injection was based on a new principle. We found in normal subjects, by the introduction of odorous substances into the nasal passages during periods of voluntary cessation of breathing, in known volume and under a known pressure, that a certain volume and pressure were necessary for the recognition and identification of the odor. The minimum volume required for the identification of the odor was called the minimum identifiable odor of the odorous substance. Furthermore, we found that the stream injection of an odorous substance for a fixed period produced olfactory fatigue—inability to identify the odor when injected into the nasal passage by blast injection—from which normal subjects recovered within a definite References 1. Elsberg, C. A., and Levy, I.: A New and Simple Method of Quantitative Olfactometry , Bull. Neurol. Inst. New York 4:5-19, 1935. 2. Elsberg, C. A.; Brewer, E. D., and Levy, I.: The Odorous Substances to Be Used for Tests of the Olfactory Sense , Bull. Neurol. Inst. New York 4:286-293, 1935 3. The Relative Importance of Volume and Pressure of the Impulse for the Sensation of Smell, and the Nature of the Olfactory Process , Elsberg Bull. Neurol. Inst. New York 4:264-269, 1935. 4. Adler, A., and Finley, K. H.: Clinical Results with Elsberg's Olfactory Test , Arch. Neurol. & Psychiat. 40:147 ( (July) ) 1938. 5. Echols, D. H.; Richter, H. J., and Peet, M. M.: The Effect of Zinc Sulphate on the Sense of Smell , Bull. Univ. Hosp., Ann Arbor 3:32-33, 1937. 6. Spillane, J. D.: Clinical Investigations of Olfactory Function in Brain Tumor Patients , Brain 62:213-221, 1939. 7. Elsberg, C. A.: The Value of Quantitative Olfactory Tests for the Localization of Supratentorial Tumors of the Brain , Bull. Neurol. Inst. New York 4:511-522, 1935 8. The Localization of Supratentorial Tumors of the Brain by Olfactory Tests , Ann. Int. Med. 10:49-57, 1936 9. The Localization of Tumors of the Frontal Lobes of the Brain by Quantitative Olfactory Tests , Bull. Neurol. Inst. New York 4:535-543, 1936. 10. Elsberg, C., and Stewart, J.: Quantitative Olfactory Tests: Value in Localization and Diagnosis of Tumors of the Brain , Arch. Neurol. & Psychiat. 40:471-481 ( (Sept.) ) 1938. 11. Most of the tests were made by Miss G. Vetter. 12. In 2 of the subjects the trauma to the head was of slight degree, while in the other 2 it was severe, with loss of consciousness for at least several hours. 13. In 5 of these patients the trauma was of slight degree, and in the remaining 7 it was severe, with loss of consciousness. 14. In 44, the cranial trauma was slight; in 18, severe with loss of consciousness.
Archives of Neurology & Psychiatry – American Medical Association
Published: Jul 1, 1942
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