Abstract ALTHOUGH the use of typhoid vaccine intravenously in the form of a fairly rapid injection has long been a controversial procedure, it has been a most widely used therapeutic agent in ophthalmology. The use of typhoid vaccine intravenously in a slow continuous infusion is a much more recent procedure. In addition to a review of the literature pertaining to the mechanism of the therapeutic action of typhoid vaccine, this paper describes a method of giving typhoid vaccine intravenously as an infusion and presents case reports to demonstrate the advantages of this method. Since typhoid vaccine was first used, several investigators, particularly in the United States, have attempted to work out procedures of administration whereby rapid and maximal benefit could be obtained without endangering the patient. Much of this work has been done outside the field of ophthalmology. Typhoid vaccine has been used intravenously in the treatment of systemic diseases for References 1. Solomon, H. A., and Somkin, E.: An Improved Method of Obtaining Sustained Controlled Hyperpyrexia with Triple Typhoid Vaccine , Am. J. M. Sc. 203:736, 1942.Crossref 2. Curry, J. J., and Shaw, E. A. : Continuous Intravenous Injection of Typhoid Vaccine in Treatment of Certain Ophthalmic Diseases , Arch. Ophth. 42:123, 1949.Crossref 3. Allen, T. D. : Typhoid Vaccine in Ophthalmology , Tr. Sect. Ophth. A. M. A. 1925, p. 135. 4. Torres, F. R. : Vacunoterapia o antigenoterpia antitifica , Semana méd. 22:1357, 1913. 5. Dessy, S. ; Grapiolo, F. L., and Fossati, V. : Nueva vacuna contra la fiebre tifoidea : Notas experimentales y clinicas , Semana méd. 21:357, 1914. 6. Cecil, R. L. : Nonspecific Protein Therapy , J. A. M. A. 105:1846. 1935.Crossref 7. Miller, J. L., and Lusk, F. B. : Treatment of Arthritis by the Intravenous Injection of Foreign Protein , J. A. M. A. 66:1756, 1916.Crossref 8. Nelson, M. O. : Improved Method of Protein Fever Treatment in Neurosyphilis , Am. J. Syph. 15:185, 1931. 9. Driver, J. P., and Shaw, H. C.: Divided Doses of Typhoid Vaccine in the Fever Therapy of Neurosyphilis , J. A. M. A. 101:2016, 1933.Crossref 10. Cordes, F. C.: Fever Therapy in Ophthalmology , J. A. M. A. 124:14, 1944.Crossref 11. Weinberg, J., and Goldstein, H. H.: Illinois M. J. 79:139, 1941. 12. Duke-Elder, W. P.: Text-Book of Ophthalmology , Vol. 3, St. Louis, C. V. Mosby Company, 1941, p. 2215. 13. Brown, A. L.: Experimental Uveitis , Tr. Am. Ophth. Soc. 33:435, 1935 14. Am. J. Ophth. 20:583, 1937. 15. Teague, O., and McWilliams, H. J.: Intravenous Vaccine Therapy , J. Immunol. 2:375, 1917. 16. Petersen, W. F.; Müller, E. F., and Boikan, W.: Reaction of Dog to the Continuous Intravenous Injection of B. Coli , J. Infect. Dis. 41:405, 1927.Crossref 17. Jobling, J. W.; Petersen, W., and Eggstein, A. A.: Serum Ferments and Antiferment After Feeding: Studies on Ferment Action , J. Exper. Med. 16:34, 1914 18. 22:141, 1915. 19. Petersen, W. F.: Protein Therapy and Nonspecific Resistance , with an Introduction by Joseph L. Miller, New York, The Macmillan Company, 1922. 20. Key, B. W.: Further Observation of Protein Injections in Severe Ocular Infection , Arch. Ophth. 51:471, 1922. 21. Sanders, T.: Nonspecific Protein Therapy in Ocular Disease , J. Iowa M. Soc. 31:51, 1941. 22. Hench, P. P.: Usual and Unusual Reactions to Protein (Fever) Therapy , Arch Int. Med. 49:1, 1932.Crossref 23. Barr, D. P.; Cecil, R. L., and DuBois, E. F.: Clinical Colorimetry: XXXII. Temperature Regulation After the Intravenous Injection of Proteose and Typhoid Bacillus , Arch. Int. Med. 29:608, 1922.Crossref 24. Duggan, W. F.: Choroiditis Centralis Serosa: Diagnosis, Pathologic Physiology and Therapy , Arch. Ophth. 27:123, 1942.Crossref 25. Gifford, S. R., and Marquardt, G.: Central Angiospastic Retinopathy , Arch. Ophth. 21:211, 1939.Crossref 26. Dunphy, E. B.: Ocular Therapeutic Principles and Practical Applications , Arch. Ophth. 44:797, 1950.Crossref 27. Vaughan, V. C.: Protein Fever: Poisonous Proteins , J. Lab. & Clin. Med. 2:15, 1916.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Sep 1, 1952
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