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USE OF TESTOSTERONE PROPIONATE IN TREATMENT OF INVOLUTIONAL PSYCHOSIS IN THE MALE

USE OF TESTOSTERONE PROPIONATE IN TREATMENT OF INVOLUTIONAL PSYCHOSIS IN THE MALE Abstract In this communication we report the results obtained from the administration of androgen to 20 male patients who exhibited signs of the involutional psychosis. Testosterone propionate1 was employed. This substance resembles the natural androgen in all respects. During the first week the patients received 70 to 75 mg. of testosterone propionate, injected intramuscularly. Ten milligrams was administered daily to 15 patients. Five patients had injections of 25 mg. three times weekly. For the next month the patients received 30 to 50 mg. weekly. When sufficient improvement was not obtained, a maintenance dose of 20 to 25 mg. was administered for another month. With 6 patients the dose was again increased from 50 to 75 mg. during the second month. The average duration of treatment was six weeks. Only 1 patient received treatment for more than three months. The progress of 15 of these patients has been followed for more References 1. The preparation, known as oreton, was furnished by Dr. Max Gilbert, Schering Corporation, Bloomfield, N.J. 2. Brew, M. F., and Davidoff, E.: The Involutional Psychoses: Psychotic Personality and Prognosis , Psychiatric Quart. 14:412-434 ( (April) ) 1940.Crossref 3. Werner, A. A.: The Male Climacteric , J. A. M. A. 112:1441-1443 ( (April 15) ) 1939.Crossref 4. Barahal, H. S.: Testosterone in Male Involutional Melancholia , Psychiatric Quart. 12:743-749 ( (Oct.) ) 1938.Crossref 5. Zeifert, M.: Massive Dose Testosterone Therapy in Male Involutional Psychosis , Psychiatric Quart. 16:319-332 ( (April) ) 1942.Crossref 6. Davidoff, E., and Goodstone, G. L.: The Endocrine Treatment of Involutional Psychosis, read at the Up-State Interhospital Conference, Utica, New York, April 1941. 7. Brew and Davidoff.2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

USE OF TESTOSTERONE PROPIONATE IN TREATMENT OF INVOLUTIONAL PSYCHOSIS IN THE MALE

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290110131007
Publisher site
See Article on Publisher Site

Abstract

Abstract In this communication we report the results obtained from the administration of androgen to 20 male patients who exhibited signs of the involutional psychosis. Testosterone propionate1 was employed. This substance resembles the natural androgen in all respects. During the first week the patients received 70 to 75 mg. of testosterone propionate, injected intramuscularly. Ten milligrams was administered daily to 15 patients. Five patients had injections of 25 mg. three times weekly. For the next month the patients received 30 to 50 mg. weekly. When sufficient improvement was not obtained, a maintenance dose of 20 to 25 mg. was administered for another month. With 6 patients the dose was again increased from 50 to 75 mg. during the second month. The average duration of treatment was six weeks. Only 1 patient received treatment for more than three months. The progress of 15 of these patients has been followed for more References 1. The preparation, known as oreton, was furnished by Dr. Max Gilbert, Schering Corporation, Bloomfield, N.J. 2. Brew, M. F., and Davidoff, E.: The Involutional Psychoses: Psychotic Personality and Prognosis , Psychiatric Quart. 14:412-434 ( (April) ) 1940.Crossref 3. Werner, A. A.: The Male Climacteric , J. A. M. A. 112:1441-1443 ( (April 15) ) 1939.Crossref 4. Barahal, H. S.: Testosterone in Male Involutional Melancholia , Psychiatric Quart. 12:743-749 ( (Oct.) ) 1938.Crossref 5. Zeifert, M.: Massive Dose Testosterone Therapy in Male Involutional Psychosis , Psychiatric Quart. 16:319-332 ( (April) ) 1942.Crossref 6. Davidoff, E., and Goodstone, G. L.: The Endocrine Treatment of Involutional Psychosis, read at the Up-State Interhospital Conference, Utica, New York, April 1941. 7. Brew and Davidoff.2

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Nov 1, 1942

References