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Use of Silicone in the Treatment of Intestinal Gas and Bloating

Use of Silicone in the Treatment of Intestinal Gas and Bloating Silicone defoamers have been used successfully to eliminate the mucuscovered bubbles which obstruct a gastroscopist's view of the stomach. This led to their trial in treating patients complaining of flatulence and distention. Two hundred patients, aged 23 to 84 years, were given methyl polysiloxane, a physiologically inert silicone, for four weeks to three and a half years. Although other measures had not relieved symptoms, 40 mg. of methyl polysiloxane taken orally 4 times daily produced excellent or good results in 151 patients. In a control group of 20 patients who had had excellent or good results from the methyl polysiloxane, the substitution of a lactose placebo was followed by renewed complaints within 24 hours in 18 patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Use of Silicone in the Treatment of Intestinal Gas and Bloating

JAMA , Volume 174 (16) – Dec 17, 1960

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1960.03030160038009
Publisher site
See Article on Publisher Site

Abstract

Silicone defoamers have been used successfully to eliminate the mucuscovered bubbles which obstruct a gastroscopist's view of the stomach. This led to their trial in treating patients complaining of flatulence and distention. Two hundred patients, aged 23 to 84 years, were given methyl polysiloxane, a physiologically inert silicone, for four weeks to three and a half years. Although other measures had not relieved symptoms, 40 mg. of methyl polysiloxane taken orally 4 times daily produced excellent or good results in 151 patients. In a control group of 20 patients who had had excellent or good results from the methyl polysiloxane, the substitution of a lactose placebo was followed by renewed complaints within 24 hours in 18 patients.

Journal

JAMAAmerican Medical Association

Published: Dec 17, 1960

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