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USE OF LYOPHILE PLASMA IN CORRECTION OF HYPOPROTEINEMIA AND PREVENTION OF WOUND DISRUPTION

USE OF LYOPHILE PLASMA IN CORRECTION OF HYPOPROTEINEMIA AND PREVENTION OF WOUND DISRUPTION Abstract Investigations of the causes of disruption of abdominal wounds have emphasized the importance of the premature absorption of catgut, improper wound closure, distention, postoperative coughing and the delayed fibroplasia so commonly encountered in this accident. It has been stated that some factor associated with the general state of the patient is important in the predisposition of the tissues to undergo the normal processes of wound repair. That catgut loses most of its strength when exposed to tissue fluids in much less time than many reputable manufacturers give for its absorption was borne out, in both the experimental animal and man, by studies reported from this department in 1936.1 More recently, three of us2 found that the normal processes of wound repair could be greatly retarded by experimentally producing hypoproteinemia in the dog. That other factors are important in certain instances of wound disruption we do not doubt. It References 1. Rhoads, J. E.; Hottenstein, H. F., and Hudson, I. F.: The Decline of the Strength of Catgut After Exposure to Living Tissues , Arch. Surg. 34:377 ( (March) ) 1937.Crossref 2. Thompson, W. D.; Ravdin, I. S., and Frank, I. L.: Effect of Hypoproteinemia on Wound Disruption , Arch. Surg. 36:500 ( (March) ) 1938.Crossref 3. Clark, Admont H.: The Effect of Diet on the Healing of Wounds , Bull. Johns Hopkins Hosp. 30:117, 1919. 4. Mecray, P. M.; Barden, R. P., and Ravdin, I. S.: Nutritional Edema: Its Effect on the Gastric Emptying Time Before and After Gastric Operations , Surgery 1:53, 1937. 5. Mudd, Stuart; Flosdorf, E. W.; Eagle, Harry; Stokes, J., Jr., and McGuinness, A. C.: The Preservation and Concentration of Human Serums for Clinical Use , J. A. M. A. 107:956 ( (Sept. 19) ) 1936.Crossref 6. Methyl cellosolve is ethylene glycol monomethyl ether. 7. Flosdorf, E. W., and Mudd, Stuart: Procedure and Apparatus for Preservation in "Lyophile" Form of Serum and Other Biological Substances , J. Immunol. 29:389, 1935. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

USE OF LYOPHILE PLASMA IN CORRECTION OF HYPOPROTEINEMIA AND PREVENTION OF WOUND DISRUPTION

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Publisher
American Medical Association
Copyright
Copyright © 1938 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1938.01190210138009
Publisher site
See Article on Publisher Site

Abstract

Abstract Investigations of the causes of disruption of abdominal wounds have emphasized the importance of the premature absorption of catgut, improper wound closure, distention, postoperative coughing and the delayed fibroplasia so commonly encountered in this accident. It has been stated that some factor associated with the general state of the patient is important in the predisposition of the tissues to undergo the normal processes of wound repair. That catgut loses most of its strength when exposed to tissue fluids in much less time than many reputable manufacturers give for its absorption was borne out, in both the experimental animal and man, by studies reported from this department in 1936.1 More recently, three of us2 found that the normal processes of wound repair could be greatly retarded by experimentally producing hypoproteinemia in the dog. That other factors are important in certain instances of wound disruption we do not doubt. It References 1. Rhoads, J. E.; Hottenstein, H. F., and Hudson, I. F.: The Decline of the Strength of Catgut After Exposure to Living Tissues , Arch. Surg. 34:377 ( (March) ) 1937.Crossref 2. Thompson, W. D.; Ravdin, I. S., and Frank, I. L.: Effect of Hypoproteinemia on Wound Disruption , Arch. Surg. 36:500 ( (March) ) 1938.Crossref 3. Clark, Admont H.: The Effect of Diet on the Healing of Wounds , Bull. Johns Hopkins Hosp. 30:117, 1919. 4. Mecray, P. M.; Barden, R. P., and Ravdin, I. S.: Nutritional Edema: Its Effect on the Gastric Emptying Time Before and After Gastric Operations , Surgery 1:53, 1937. 5. Mudd, Stuart; Flosdorf, E. W.; Eagle, Harry; Stokes, J., Jr., and McGuinness, A. C.: The Preservation and Concentration of Human Serums for Clinical Use , J. A. M. A. 107:956 ( (Sept. 19) ) 1936.Crossref 6. Methyl cellosolve is ethylene glycol monomethyl ether. 7. Flosdorf, E. W., and Mudd, Stuart: Procedure and Apparatus for Preservation in "Lyophile" Form of Serum and Other Biological Substances , J. Immunol. 29:389, 1935.

Journal

Archives of SurgeryAmerican Medical Association

Published: Mar 1, 1938

References