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Use of Lindane

Use of Lindane Abstract To the Editor. — In In his letter, published in the March 1988 issue of the Archives, Solomon1 questioned whether the optimal dose of lindane had been established. It is true that lindane is sold in Europe as a 0.3% solution. However, in our entomology laboratory, we tested the effectiveness of various concentrations of lindane in killing laboratorybred lice. We found that as the concentration dropped below 1.0% so too did the pediculicidal activity, precipitously so when the concentration reached 0.33% (Figure). This may explain why most of the reports of lindane resistance have come from Europe, where, probably, a sublethal concentration is used.Solomon also suggests that potential toxicity to lindane could be reduced by assuring that the lotion is washed off at a specified time. Examination of the report by Ginsburg et al2 demonstrates that this would probably not achieve the intended goal. In their study, a lindane lotion was applied to the entire body of scabetic infants and children References 1. Solomon LM: Lindane . Arch Dermatol 1988;124:321-322.Crossref 2. Ginsburg CM, Lowry W, Reisch JS: Absorption of lindane (gamma benzene hexachloride) in infants and children . J Pediatr 1977;91:998-1000.Crossref 3. Lange M, Nitzsche K, Zersch A: Percutaneous absorption of lindane in healthy volunteers and scabies patients: Dependency of penetration kinetics in serum on frequency of application, time, and mode of washing . Arch Dermatol Res 1981;271:387-399.Crossref 4. Frawley JP, Fitzhugh OG: Rate of disappearance of isomers of benzene hexachloride from fat depots in rats . Fed Proc 1949;8:292. 5. Lehman AJ: Insect repellants: Report of the Association of Food and Drug Officers . US Q Bull 1952;16:85. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670120074018
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. — In In his letter, published in the March 1988 issue of the Archives, Solomon1 questioned whether the optimal dose of lindane had been established. It is true that lindane is sold in Europe as a 0.3% solution. However, in our entomology laboratory, we tested the effectiveness of various concentrations of lindane in killing laboratorybred lice. We found that as the concentration dropped below 1.0% so too did the pediculicidal activity, precipitously so when the concentration reached 0.33% (Figure). This may explain why most of the reports of lindane resistance have come from Europe, where, probably, a sublethal concentration is used.Solomon also suggests that potential toxicity to lindane could be reduced by assuring that the lotion is washed off at a specified time. Examination of the report by Ginsburg et al2 demonstrates that this would probably not achieve the intended goal. In their study, a lindane lotion was applied to the entire body of scabetic infants and children References 1. Solomon LM: Lindane . Arch Dermatol 1988;124:321-322.Crossref 2. Ginsburg CM, Lowry W, Reisch JS: Absorption of lindane (gamma benzene hexachloride) in infants and children . J Pediatr 1977;91:998-1000.Crossref 3. Lange M, Nitzsche K, Zersch A: Percutaneous absorption of lindane in healthy volunteers and scabies patients: Dependency of penetration kinetics in serum on frequency of application, time, and mode of washing . Arch Dermatol Res 1981;271:387-399.Crossref 4. Frawley JP, Fitzhugh OG: Rate of disappearance of isomers of benzene hexachloride from fat depots in rats . Fed Proc 1949;8:292. 5. Lehman AJ: Insect repellants: Report of the Association of Food and Drug Officers . US Q Bull 1952;16:85.

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1988

References