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Use of Griseofulvin in the Therapy of Tinea Capitis in Children: Preliminary Observations

Use of Griseofulvin in the Therapy of Tinea Capitis in Children: Preliminary Observations Abstract For a number of years, the District of Columbia's Department of Public Health has been contending with tinea capitis infections among school children and their preschool siblings. From fewer than 500 new cases seen in the Ringworm Clinic of this department in the years 1949-1951, the number of new cases rose to a peak of 1,766 in 1956 (Figure). In order to cope with this increasing problem, two and one-half years ago the Department of Public Health in consultation with the Mycology Unit of the Communicable Disease Center of the United States Public Health Service developed an intensive case-finding and systematic followup program. Wood's-light surveys of students in the affected schools were initiated, and suspected cases were cultured at a central clinic and confirmed cases placed under treatment and closely supervised. Thereafter, a gradually rising incidence of infection that had begun in 1951 and which had References 1. Use of trade names does not constitute endorsement by the U. S. Public Health Service or the District of Columbia Department of Public Health. 2. Mycosel Agar, Baltimore Biological Laboratory. (Use of trade names does not constitute endorsement by the U. S. Public Health Service.) 3. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature, London 182:476-477, 1958.Crossref 4. Blank, H., and Roth, J. F., Jr.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A. M. A. Arch. Dermat. 79:259-266, 1959.Crossref 5. Oxford, A. E.; Raistrick, H., and Simonart, P.: XXIX. Studies in the Biochemistry of Micro-Organisms: LX. Griseofulvin, C17H17O6Cl, a Metabolic Product of Penicillin Griseo-Fulvum Dierchx. , Biochem. J. 33:240-248, 1939. 6. Brian, P. W.; Curtis, P. J., and Hemming, H. G.: A Substance Causing Abnormal Development of Fungal Hyphae Produced by Penicillium Janczewski Zal: 1. Biological Assay, Production and Isolation of ``Curling-Factor,'' Tr. Brit. Mycol. Soc. 29:173-187, 1946.Crossref 7. Grove, J. F., and McGowan, J. C.: Identity of Griseofulvin and ``Curling-Factor,'' Nature, London 160:574, 1947.Crossref 8. Brian, P. W.; Wright, J. M.; Stubbs, J., and Way, A. M.: Uptake of Antibiotic Metabolites of Soil Micro-Organisms by Plants , Nature, London 167:347-349, 1951.Crossref 9. Stubbs, J.: The Evaluation of Systemic Fungicides by Means of Alternaria Solani on Tomato , Ann. Appl. Bot. 39:439-441, 1952.Crossref 10. Rhodes, A.; Crosse, R.; McWilliam, R.; Tootill, J. P. R., and Dunn, A. T.: Small-Plot Trials of Griseofulvin as a Fungicide , Ann. Applied Biol. 45:215-226, 1957.Crossref 11. Georg, L. K.; Ajello, L., and Papageorge, C.: Use of Cycloheximide in the Selective Isolation of Fungi Pathogenic to Man , J. Lab. & Clin. Med. 44:422-428, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Use of Griseofulvin in the Therapy of Tinea Capitis in Children: Preliminary Observations

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560210001001
Publisher site
See Article on Publisher Site

Abstract

Abstract For a number of years, the District of Columbia's Department of Public Health has been contending with tinea capitis infections among school children and their preschool siblings. From fewer than 500 new cases seen in the Ringworm Clinic of this department in the years 1949-1951, the number of new cases rose to a peak of 1,766 in 1956 (Figure). In order to cope with this increasing problem, two and one-half years ago the Department of Public Health in consultation with the Mycology Unit of the Communicable Disease Center of the United States Public Health Service developed an intensive case-finding and systematic followup program. Wood's-light surveys of students in the affected schools were initiated, and suspected cases were cultured at a central clinic and confirmed cases placed under treatment and closely supervised. Thereafter, a gradually rising incidence of infection that had begun in 1951 and which had References 1. Use of trade names does not constitute endorsement by the U. S. Public Health Service or the District of Columbia Department of Public Health. 2. Mycosel Agar, Baltimore Biological Laboratory. (Use of trade names does not constitute endorsement by the U. S. Public Health Service.) 3. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature, London 182:476-477, 1958.Crossref 4. Blank, H., and Roth, J. F., Jr.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A. M. A. Arch. Dermat. 79:259-266, 1959.Crossref 5. Oxford, A. E.; Raistrick, H., and Simonart, P.: XXIX. Studies in the Biochemistry of Micro-Organisms: LX. Griseofulvin, C17H17O6Cl, a Metabolic Product of Penicillin Griseo-Fulvum Dierchx. , Biochem. J. 33:240-248, 1939. 6. Brian, P. W.; Curtis, P. J., and Hemming, H. G.: A Substance Causing Abnormal Development of Fungal Hyphae Produced by Penicillium Janczewski Zal: 1. Biological Assay, Production and Isolation of ``Curling-Factor,'' Tr. Brit. Mycol. Soc. 29:173-187, 1946.Crossref 7. Grove, J. F., and McGowan, J. C.: Identity of Griseofulvin and ``Curling-Factor,'' Nature, London 160:574, 1947.Crossref 8. Brian, P. W.; Wright, J. M.; Stubbs, J., and Way, A. M.: Uptake of Antibiotic Metabolites of Soil Micro-Organisms by Plants , Nature, London 167:347-349, 1951.Crossref 9. Stubbs, J.: The Evaluation of Systemic Fungicides by Means of Alternaria Solani on Tomato , Ann. Appl. Bot. 39:439-441, 1952.Crossref 10. Rhodes, A.; Crosse, R.; McWilliam, R.; Tootill, J. P. R., and Dunn, A. T.: Small-Plot Trials of Griseofulvin as a Fungicide , Ann. Applied Biol. 45:215-226, 1957.Crossref 11. Georg, L. K.; Ajello, L., and Papageorge, C.: Use of Cycloheximide in the Selective Isolation of Fungi Pathogenic to Man , J. Lab. & Clin. Med. 44:422-428, 1954.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1959

References