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USE OF CURARE IN OIL IN TREATMENT OF SPASTICITY FOLLOWING INJURY OF THE SPINAL CORD

USE OF CURARE IN OIL IN TREATMENT OF SPASTICITY FOLLOWING INJURY OF THE SPINAL CORD Abstract WEST,1 Burman,2 Bennett3 and others described the use of preparations of curare in treatment of various syndromes exhibiting spasticity, tremor and rigidity. They found that curare diminished hypertonia, tremor and involuntary movements. The clinical effect, however, was usually transient and therefore of questionable therapeutic value. Denhoff and Bradley,4 in a group of spastic children, found that the initial period of response to effective doses was characterized by masked facies, head drop and mental confusion. After these unpleasant reactions had worn off, the useful clinical effect became evident. These therapeutic experiments were carried out with aqueous solutions of the drug, used either intravenously or intramuscularly. In the present study a group of patients showing intense spasticity accompanying injury to the spinal cord were treated with aqueous solutions of curare. Eleven patients with extreme spasticity were chosen from a large group. Of these 11, 9 had complete paraplegia References 1. West, R.: Curare in Man , Proc. Roy. Soc. Med. 25:1107-1116 ( (May) ) 1932. 2. Burman, M. S.: Clinical Experiences with Some Curare Preparations and Curare Substitutes , J. Pharmacol. & Exper. Therap. 69:143-148 ( (June) ) 1940. 3. Bennett, A. E.: Clinical Investigations with Curare in Organic Neurologic Disorders , Am. J. M. Sc. 202:102-112 ( (July) ) 1941. 4. Denhoff, E., and Bradley, C.: Curare Treatment of Spastic Children: Preliminary Report , New England J. Med. 226:411-416 ( (March 12) ) 1942. 5. Romansky, M. J., and Rittman, G. E.: Method of Prolonging Action of Penicillin, abstracted , Science 100:196-198 ( (Sept.) ) 1944. 6. The tubocurarine was supplied by E. R. Squibb & Sons, New York. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

USE OF CURARE IN OIL IN TREATMENT OF SPASTICITY FOLLOWING INJURY OF THE SPINAL CORD

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Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1946.02300160093004
Publisher site
See Article on Publisher Site

Abstract

Abstract WEST,1 Burman,2 Bennett3 and others described the use of preparations of curare in treatment of various syndromes exhibiting spasticity, tremor and rigidity. They found that curare diminished hypertonia, tremor and involuntary movements. The clinical effect, however, was usually transient and therefore of questionable therapeutic value. Denhoff and Bradley,4 in a group of spastic children, found that the initial period of response to effective doses was characterized by masked facies, head drop and mental confusion. After these unpleasant reactions had worn off, the useful clinical effect became evident. These therapeutic experiments were carried out with aqueous solutions of the drug, used either intravenously or intramuscularly. In the present study a group of patients showing intense spasticity accompanying injury to the spinal cord were treated with aqueous solutions of curare. Eleven patients with extreme spasticity were chosen from a large group. Of these 11, 9 had complete paraplegia References 1. West, R.: Curare in Man , Proc. Roy. Soc. Med. 25:1107-1116 ( (May) ) 1932. 2. Burman, M. S.: Clinical Experiences with Some Curare Preparations and Curare Substitutes , J. Pharmacol. & Exper. Therap. 69:143-148 ( (June) ) 1940. 3. Bennett, A. E.: Clinical Investigations with Curare in Organic Neurologic Disorders , Am. J. M. Sc. 202:102-112 ( (July) ) 1941. 4. Denhoff, E., and Bradley, C.: Curare Treatment of Spastic Children: Preliminary Report , New England J. Med. 226:411-416 ( (March 12) ) 1942. 5. Romansky, M. J., and Rittman, G. E.: Method of Prolonging Action of Penicillin, abstracted , Science 100:196-198 ( (Sept.) ) 1944. 6. The tubocurarine was supplied by E. R. Squibb & Sons, New York.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: May 1, 1946

References