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USE OF BISHYDROXYCOUMARIN (DICUMAROL) FOR PREVENTION OF POSTOPERATIVE THROMBOEMBOLISM: A Study of Twenty-Seven Hundred Consecutive Surgical Patients

USE OF BISHYDROXYCOUMARIN (DICUMAROL) FOR PREVENTION OF POSTOPERATIVE THROMBOEMBOLISM: A Study of... Abstract THROMBOEMBOLISM is a disorder of the normal circulation of the blood which results in complete or partial obstruction of large vessels and may or may not result in detachment of a portion of the thrombus with its lodgment at another site. Thrombosis due to intravascular clotting of the circulating blood may occur in any portion of the circulatory system. Venous thrombosis, with which we are most concerned in this study, occurs most prominently in the veins of the lower extremities; in the veins of the pelvis, including the parauterine and paraprostatic veins, and occasionally in the veins of the upper extremities. The entity of intravascular thrombosis has been recognized since the time of Hippocrates and Galen. Virchow, in 1846, was one of the earliest authors to advance the theory and demonstrate that pulmonary emboli arose from thrombi in the pelvic or femoral veins. Early in the 20th century repeated reports References 1. Beckman, E. H.: Complications Following Surgical Operations: A Report of the Complications and Deaths in a Series of 5,835 Surgical Operations Performed in the Mayo Clinic, St. Mary's Hospital, in the Year 1912 , Ann. Surg. 57:718-729, 1913.Crossref 2. Miller, R. H., and Rogers, H.: Postoperative Embolism and Phlebitis , J. A. M. A. 93:1452-1456 ( (Nov. 9) ) 1929.Crossref 3. Wilson, L. B.: Fatal Postoperative Embolism , Ann. Surg. 56:809-817, 1912.Crossref 4. (a) McLachlin, J., and Paterson, J. C.: Some Basic Observations on Venous Thrombosis and Pulmonary Embolism , Surg., Gynec. & Obst. 93:1-8 ( (July) ) 1951. 5. (b) Allen, E. V.; Barker, N. W., and Hines, E. A., Jr.: Peripheral Vascular Diseases , Philadelphia, W. B. Saunders Company, 1946. 6. Barker, N. W.; Nygaard, K. K.; Walters, W., and Priestley, J. T.: A Statistical Study of Postoperative Venous Thrombosis and Pulmonary Embolism: I. Incidence in Various Types of Operations , Proc. Staff Meet., Mayo Clin. 15:769-773 ( (Dec. 4) ) 1940 7. III. Time of Occurrence During the Postoperative Period , Barker Proc. Staff Meet., Mayo Clin. 16:17-21 ( (Jan. 8) ) 1941. 8. Zilliacus, H.: On the Specific Treatment of Thrombosis and Pulmonary Embolism with Anticoagulants, with Particular Reference to the Post-Thrombotic Sequelae, Results of 5 Years' Treatment of Thrombosis and Pulmonary Embolism at Series of Swedish Hospitals During Years 1940-1945 , Acta med. scandinav. 1946, (Supp. 171) , p. 1. 9. Ochsner, A.; Debakey, E., and DeCamp, P. T.: Venous Thrombosis , J. A. M. A. 144:831-834 ( (Nov. 4) ) 1950. 10. Kirby, C. K., and Fitts, W. T., Jr.: Thromboembolic Complications in Surgical Patients , Surgery 27:564-571 ( (April) ) 1950. 11. Aufses, A. H., and Neuhof, H.: Causes of Death After Operation: Comparison Between Last Decade and 1920's , J. Mt. Sinai Hosp. 18:166-178 ( (Sept.-Oct.) ) 1951. 12. Allen, A. W.; Linton, R. R., and Donaldson, G. A.: Thrombosis and Embolism: Review of 202 Patients Treated by Femoral Vein Interruption , Ann. Surg. 118:728-740 ( (Oct.) ) 1943 13. Venous Thrombosis and Pulmonary Embolism , J. A. M. A. 133:1268-1274 ( (April 26) ) 1947. 14. Allen, A. W.: The Present Evaluation of the Prophylaxis and Treatment of Venous Thrombosis and Pulmonary Embolism , Surgery 26:1-7 ( (July) ) 1949. 15. Roe, B. B., and Goldthwaite, J. C.: Pulmonary Embolism: A Statistical Study of Post-Mortem Material at the Massachusetts General Hospital , New England J. Med. 241:679-686 ( (Nov. 3) ) 1949. 16. de Takats, G.: Management of Pulmonary Embolism , Postgrad. Med. 8:506-509 ( (Dec.) ) 1950. 17. de Takats, G., and Fowler, E. F.: Problem of Thrombo-Embolism , Surgery 17:153-177 ( (Feb.) ) 1945. 18. Crutcher, R. R., and Daniel, R. A., Jr.: Pulmonary Embolism: A Correlation of Clinical and Autopsy Material , Surgery 23:47-62 ( (Jan.) ) 1948. 19. Major operative procedures include all operations performed in the abdominal cavity and pelvis, including herniotomy and appendectomy for complicated appendicitis. 20. Sachs, J. J., and Henderson, R. R.: Use of Bishydroxycoumarin (Dicumarol) in the Presence of Impaired Renal Function , J. A. M. A. 148:839-841 ( (March 8) ) 1952. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

USE OF BISHYDROXYCOUMARIN (DICUMAROL) FOR PREVENTION OF POSTOPERATIVE THROMBOEMBOLISM: A Study of Twenty-Seven Hundred Consecutive Surgical Patients

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Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1953.01260040147004
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Abstract

Abstract THROMBOEMBOLISM is a disorder of the normal circulation of the blood which results in complete or partial obstruction of large vessels and may or may not result in detachment of a portion of the thrombus with its lodgment at another site. Thrombosis due to intravascular clotting of the circulating blood may occur in any portion of the circulatory system. Venous thrombosis, with which we are most concerned in this study, occurs most prominently in the veins of the lower extremities; in the veins of the pelvis, including the parauterine and paraprostatic veins, and occasionally in the veins of the upper extremities. The entity of intravascular thrombosis has been recognized since the time of Hippocrates and Galen. Virchow, in 1846, was one of the earliest authors to advance the theory and demonstrate that pulmonary emboli arose from thrombi in the pelvic or femoral veins. Early in the 20th century repeated reports References 1. Beckman, E. H.: Complications Following Surgical Operations: A Report of the Complications and Deaths in a Series of 5,835 Surgical Operations Performed in the Mayo Clinic, St. Mary's Hospital, in the Year 1912 , Ann. Surg. 57:718-729, 1913.Crossref 2. Miller, R. H., and Rogers, H.: Postoperative Embolism and Phlebitis , J. A. M. A. 93:1452-1456 ( (Nov. 9) ) 1929.Crossref 3. Wilson, L. B.: Fatal Postoperative Embolism , Ann. Surg. 56:809-817, 1912.Crossref 4. (a) McLachlin, J., and Paterson, J. C.: Some Basic Observations on Venous Thrombosis and Pulmonary Embolism , Surg., Gynec. & Obst. 93:1-8 ( (July) ) 1951. 5. (b) Allen, E. V.; Barker, N. W., and Hines, E. A., Jr.: Peripheral Vascular Diseases , Philadelphia, W. B. Saunders Company, 1946. 6. Barker, N. W.; Nygaard, K. K.; Walters, W., and Priestley, J. T.: A Statistical Study of Postoperative Venous Thrombosis and Pulmonary Embolism: I. Incidence in Various Types of Operations , Proc. Staff Meet., Mayo Clin. 15:769-773 ( (Dec. 4) ) 1940 7. III. Time of Occurrence During the Postoperative Period , Barker Proc. Staff Meet., Mayo Clin. 16:17-21 ( (Jan. 8) ) 1941. 8. Zilliacus, H.: On the Specific Treatment of Thrombosis and Pulmonary Embolism with Anticoagulants, with Particular Reference to the Post-Thrombotic Sequelae, Results of 5 Years' Treatment of Thrombosis and Pulmonary Embolism at Series of Swedish Hospitals During Years 1940-1945 , Acta med. scandinav. 1946, (Supp. 171) , p. 1. 9. Ochsner, A.; Debakey, E., and DeCamp, P. T.: Venous Thrombosis , J. A. M. A. 144:831-834 ( (Nov. 4) ) 1950. 10. Kirby, C. K., and Fitts, W. T., Jr.: Thromboembolic Complications in Surgical Patients , Surgery 27:564-571 ( (April) ) 1950. 11. Aufses, A. H., and Neuhof, H.: Causes of Death After Operation: Comparison Between Last Decade and 1920's , J. Mt. Sinai Hosp. 18:166-178 ( (Sept.-Oct.) ) 1951. 12. Allen, A. W.; Linton, R. R., and Donaldson, G. A.: Thrombosis and Embolism: Review of 202 Patients Treated by Femoral Vein Interruption , Ann. Surg. 118:728-740 ( (Oct.) ) 1943 13. Venous Thrombosis and Pulmonary Embolism , J. A. M. A. 133:1268-1274 ( (April 26) ) 1947. 14. Allen, A. W.: The Present Evaluation of the Prophylaxis and Treatment of Venous Thrombosis and Pulmonary Embolism , Surgery 26:1-7 ( (July) ) 1949. 15. Roe, B. B., and Goldthwaite, J. C.: Pulmonary Embolism: A Statistical Study of Post-Mortem Material at the Massachusetts General Hospital , New England J. Med. 241:679-686 ( (Nov. 3) ) 1949. 16. de Takats, G.: Management of Pulmonary Embolism , Postgrad. Med. 8:506-509 ( (Dec.) ) 1950. 17. de Takats, G., and Fowler, E. F.: Problem of Thrombo-Embolism , Surgery 17:153-177 ( (Feb.) ) 1945. 18. Crutcher, R. R., and Daniel, R. A., Jr.: Pulmonary Embolism: A Correlation of Clinical and Autopsy Material , Surgery 23:47-62 ( (Jan.) ) 1948. 19. Major operative procedures include all operations performed in the abdominal cavity and pelvis, including herniotomy and appendectomy for complicated appendicitis. 20. Sachs, J. J., and Henderson, R. R.: Use of Bishydroxycoumarin (Dicumarol) in the Presence of Impaired Renal Function , J. A. M. A. 148:839-841 ( (March 8) ) 1952.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Aug 1, 1953

References