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Use of Autologous Serum in the Treatment of Ocular Surface Disorders

Use of Autologous Serum in the Treatment of Ocular Surface Disorders EDITORIAL Use of Autologous Serum in the Treatment of Ocular Surface Disorders HE USE OF AUTOLOGOUS SERUM FOR TREAT- PERSISTENT EPITHELIAL DEFECTS ing ocular surface disorder has a long his- tory that dates back at least to the 1970s Several studies have described the successful use of au- when autologous serum was used via a mo- tologous serum in the treatment of persistent epithelial T bile ocular perfusion pump to treat ocu- defects recalcitrant to standard medical therapies. Dif- 1 2 lar alkali burns. Subsequently, a report in the rheuma- 3,4,7-10 ferent investigators have used concentrations of au- tologic literature appeared in 1984 discussing the use of tologous serum ranging from 20% to 100% in the treat- autologous serum as a tear substitute. Although prob- ment of persistent epithelial defects and have demonstrated ably used more often than it was publicized to be, the a healing rate of between 20% and 60% at 2 weeks and use of autologous serum for the treatment of ocular sur- between 47% and 83% at 4 weeks. Furthermore, it has face disorder did not appear to garner widespread inter- been suggested that the length of time required for heal- est until the late http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Use of Autologous Serum in the Treatment of Ocular Surface Disorders

JAMA Ophthalmology , Volume 129 (12) – Dec 1, 2011

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/archophthalmol.2011.336
pmid
22159683
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Use of Autologous Serum in the Treatment of Ocular Surface Disorders HE USE OF AUTOLOGOUS SERUM FOR TREAT- PERSISTENT EPITHELIAL DEFECTS ing ocular surface disorder has a long his- tory that dates back at least to the 1970s Several studies have described the successful use of au- when autologous serum was used via a mo- tologous serum in the treatment of persistent epithelial T bile ocular perfusion pump to treat ocu- defects recalcitrant to standard medical therapies. Dif- 1 2 lar alkali burns. Subsequently, a report in the rheuma- 3,4,7-10 ferent investigators have used concentrations of au- tologic literature appeared in 1984 discussing the use of tologous serum ranging from 20% to 100% in the treat- autologous serum as a tear substitute. Although prob- ment of persistent epithelial defects and have demonstrated ably used more often than it was publicized to be, the a healing rate of between 20% and 60% at 2 weeks and use of autologous serum for the treatment of ocular sur- between 47% and 83% at 4 weeks. Furthermore, it has face disorder did not appear to garner widespread inter- been suggested that the length of time required for heal- est until the late

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Dec 1, 2011

References

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