Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

USE AND ABUSE OF PSORALENS

USE AND ABUSE OF PSORALENS The psoralens1 are furocoumarins to which most people in the United States have been exposed. Celery contains psoralen. Oil of bergamot, widely used in perfumes, contains 5-methoxypsoralen. Thus, there are few persons who have not ingested psoralen and probably no adult woman who has not applied a psoralen to her skin. Plants containing psoralen have been used to produce pigmentation for at least 3,000 years. Recently, oil of bergamot has been used for this purpose. Scientific investigation of the psoralens began when Kuske2 and, later, Fahmy and his group3 isolated the active chemicals from a variety of plants. Many physicians in different countries began to study these compounds. Lerner, Denton, and Fitzpatrick4 and Kelly and Pinkus5 initiated clinical evaluation in the United States. The chemical alterations in the psoralesn which occur after oral ingestion or topical application to the skin are not known. Exposure of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

USE AND ABUSE OF PSORALENS

JAMA , Volume 173 (13) – Jul 30, 1960

Loading next page...
 
/lp/american-medical-association/use-and-abuse-of-psoralens-nX5GgJtAgv
Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1960.73020310008020
Publisher site
See Article on Publisher Site

Abstract

The psoralens1 are furocoumarins to which most people in the United States have been exposed. Celery contains psoralen. Oil of bergamot, widely used in perfumes, contains 5-methoxypsoralen. Thus, there are few persons who have not ingested psoralen and probably no adult woman who has not applied a psoralen to her skin. Plants containing psoralen have been used to produce pigmentation for at least 3,000 years. Recently, oil of bergamot has been used for this purpose. Scientific investigation of the psoralens began when Kuske2 and, later, Fahmy and his group3 isolated the active chemicals from a variety of plants. Many physicians in different countries began to study these compounds. Lerner, Denton, and Fitzpatrick4 and Kelly and Pinkus5 initiated clinical evaluation in the United States. The chemical alterations in the psoralesn which occur after oral ingestion or topical application to the skin are not known. Exposure of

Journal

JAMAAmerican Medical Association

Published: Jul 30, 1960

There are no references for this article.