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Urticaria Pigmentosa with Generalized Tissue Mastocytosis and Blood Basophilia

Urticaria Pigmentosa with Generalized Tissue Mastocytosis and Blood Basophilia Abstract In recent years there have been several reports on urticaria pigmentosa as just one phenomenon of a systemic mast-cell disease. Mast-cell accumulations have been demonstrated in several internal organs and tissues, giving rise to enlargements of the organs and to infiltration, rarefaction, and sclerosis of bones and other connective tissues.1-4 However, reports on symptoms arising from increased formation of mastcell products (hyaluronic acid, heparin, histamine, serotonin) have been relatively rare. The stimulated connective tissue regeneration and fibrosis, which has been noted in many cases, is depending on a release of ground-substance mucopolysaccharides of the hyaluronic acid type by the mast cells.5 Disturbances of the blood coagulation mechanism have been reported in a few cases.6 They may or may not have been related to the content of heparin-like substances in mast-cell granules.7Histamine, known to be synthesized in mast cells,8,9 may well play a role for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Urticaria Pigmentosa with Generalized Tissue Mastocytosis and Blood Basophilia

A.M.A. Archives of Dermatology , Volume 81 (2) – Feb 1, 1960

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730020034005
Publisher site
See Article on Publisher Site

Abstract

Abstract In recent years there have been several reports on urticaria pigmentosa as just one phenomenon of a systemic mast-cell disease. Mast-cell accumulations have been demonstrated in several internal organs and tissues, giving rise to enlargements of the organs and to infiltration, rarefaction, and sclerosis of bones and other connective tissues.1-4 However, reports on symptoms arising from increased formation of mastcell products (hyaluronic acid, heparin, histamine, serotonin) have been relatively rare. The stimulated connective tissue regeneration and fibrosis, which has been noted in many cases, is depending on a release of ground-substance mucopolysaccharides of the hyaluronic acid type by the mast cells.5 Disturbances of the blood coagulation mechanism have been reported in a few cases.6 They may or may not have been related to the content of heparin-like substances in mast-cell granules.7Histamine, known to be synthesized in mast cells,8,9 may well play a role for

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1960

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