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Urticaria Pigmentosa and Generalized Mastocytosis: Polymyxin B Treatment

Urticaria Pigmentosa and Generalized Mastocytosis: Polymyxin B Treatment Abstract Polymyxin B is known to bring about degranulation of tissue mast cells and release of histamine in the rat and hamster.3-5 The following experiment was carried out on a patient with generalized mastocytosis as an attempt to change the clinical condition which had turned out to be fatal and resistant to any applied therapy. The history of the patient has been published in the A.M.A. Archives of Dermatology, 1960.1 During 5 years the man, aged 34, had developed a generalized mastocytosis involving skin (urticaria pigmentosa), liver, spleen, lymph glands, lungs, bones, bone marrow, and blood. The condition was leukemoid with the unique characteristic of pronounced blood basophilia. After a complete failure of intense treatment with prednisone and an antimitotic drug (Mitostan), treatment with polymyxin B (Pfizer), 50 mg. twice daily, was started. Four days after the first injection and through all the period of treatment it was not References 1. Asboe-Hansen, G.: A.M.A. Arch. Dermat. 81:198, 1960Crossref 2. Boseila, A.-W. A.: Thesis, Ejnar Munksgaard Forlag, Copenhagen, 1959. 3. Fiore-Donati, L., and Moltke, E.: Acta Endocr. (Kbh.) 34:430, 1960 4. Lonkar, N.: Unpublished data. 5. Parratt, J. R., and West, G. B.: J. Physiol. 137:179, 1957 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Urticaria Pigmentosa and Generalized Mastocytosis: Polymyxin B Treatment

Archives of Dermatology , Volume 83 (6) – Jun 1, 1961

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1961.01580120005001
Publisher site
See Article on Publisher Site

Abstract

Abstract Polymyxin B is known to bring about degranulation of tissue mast cells and release of histamine in the rat and hamster.3-5 The following experiment was carried out on a patient with generalized mastocytosis as an attempt to change the clinical condition which had turned out to be fatal and resistant to any applied therapy. The history of the patient has been published in the A.M.A. Archives of Dermatology, 1960.1 During 5 years the man, aged 34, had developed a generalized mastocytosis involving skin (urticaria pigmentosa), liver, spleen, lymph glands, lungs, bones, bone marrow, and blood. The condition was leukemoid with the unique characteristic of pronounced blood basophilia. After a complete failure of intense treatment with prednisone and an antimitotic drug (Mitostan), treatment with polymyxin B (Pfizer), 50 mg. twice daily, was started. Four days after the first injection and through all the period of treatment it was not References 1. Asboe-Hansen, G.: A.M.A. Arch. Dermat. 81:198, 1960Crossref 2. Boseila, A.-W. A.: Thesis, Ejnar Munksgaard Forlag, Copenhagen, 1959. 3. Fiore-Donati, L., and Moltke, E.: Acta Endocr. (Kbh.) 34:430, 1960 4. Lonkar, N.: Unpublished data. 5. Parratt, J. R., and West, G. B.: J. Physiol. 137:179, 1957

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1961

References