Abstract Untoward effects resulting from tryparsamide are relatively infrequent. Cutaneous reactions to the drug have been occasionally reported. They have appeared after few and after a great many injections. Ebaugh and Dickson1 in 1924 were the first to mention mild dermatitis due to tryparsamide. This comment was made casually in a paper on the use of the drug in the treatment of dementia paralytica. There have been four reports of mild exfoliative dermatitis2 and two of unqualified exfoliative dermatitis.3 A fixed dermatitis due to tryparsamide has also been described in four reports.4 One case in which herpes zoster appeared after several injections of tryparsamide has been reported.5 Ellis6 reported a case in which a papular eruption developed which became covered with serosanguineous crusts after the use of tryparsamide. Twelve cases in the literature have been labeled merely cases of "dermatitis," the type of lesion not References 1. Ebaugh, F. G., and Dickson, R. W.: The Use of Tryparsamide in the Treatment of General Paralysis , J. A. M. A. 83:803 ( (Sept. 13) ) 1924.Crossref 2. (a) O'Leary, P. A., and Becker, S. W.: Further Observations on the Treatment of Neurosyphilis with Tryparsamide , M. J. & Rec. 123:305 ( (March 3) ) 1926. 3. (b) Phelps, J. R.: Reactions Incidental to the Administration of 191,778 Doses of Neoarsphenamine and Other Arsenical Compounds in the United States Navy , U. S. Nav. M. Bull. 27:205 ( (Jan.) ) 1929. 4. (c) Robinson, S. S.: Dermatitis Due to Tryparsamide , Arch. Dermat. & Syph. 34:251 ( (Aug.) ) 1936. 5. (d) Nair, V. G.: Exfoliative Dermatitis After Tryparsamide , Indian J. Ven. Dis. 3:13 ( (March) ) 1937. 6. (a) Bragman, L. J.: Tryparsamide Dermatitis , Am. J. Syph. & Neurol. 18: 308 ( (July) ) 1934. 7. (b) Golz, H. H.: Sensitivity to Arsenical Drugs , Am. J. Syph., Gonor. & Ven. Dis. 23:344 ( (May) ) 1939. 8. (a) Robinson, H. M.: Fixed Dermatitis Due to Tryparsamide , Am. J. Syph. 17:507 ( (Oct.) ) 1933. 9. (b) Kemp, J. E., and Menninger, W. C.: Fixed Eruption Due to Tryparsamide , Am. J. Syph. & Neurol. 19:195 ( (April) ) 1935. 10. (c) Pillsbury, D. M.: Fixed Arsenical Eruption , Arch. Dermat. & Syph. 34:103 ( (July) ) 1936. 11. (d) Kopp, I., and Solomon, H. C.: The Untoward Reactions of Tryparsamide , Am. J. Syph., Gonor. & Ven. Dis. 24:265 ( (May) ) 1940. 12. Rosenberg, W. A.: Bilateral Asymmetrical Herpes Zoster Following Tryparsamide Therapy , Illinois M. J. 74:164 ( (Aug.) ) 1938. 13. Ellis, F. A.: Tryparsamide Dermatitis , Am. J. Syph., Gonor. & Ven. Dis. 22:336 ( (May) ) 1938. 14. (a) Keith, T. S., and LeMarquand, H. S.: Some Notes on Tryparsamide Therapy in a Venereal Disease Clinic , Brit. J. Ven. Dis. 5:38 ( (Jan.) ) 1929. 15. (b) Lichtenstein, J. V.: Tryparsamide Therapy: A Follow-Up Report on Seventy-Six Patients with Neurosyphilis Treated with Tryparsamide , Arch. Dermat. & Syph. 24:182 ( (Aug.) ) 1931. 16. (c) Cole, H. N., and others: Toxic Effects Following Use of the Arsphenamines , J. A. M. A. 97:897 ( (Sept. 26) ) 1931.
Archives of Dermatology and Syphilology – American Medical Association
Published: Oct 1, 1941