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Urine pH and Salicylate Therapy

Urine pH and Salicylate Therapy To the Editor.— The pronounced effect of urine pH on the renal clearance of salicylate is well known. Renal excretion is, however, only one of several pathways by which salicylate is eliminated from the body. The recently accomplished total characterization of the pharmacokinetics of salicylate elimination in man1,2 has made it possible to carry out computer simulations of the time course of salicylate levels in the body during long-term drug administration under different conditions. These simulations predicted that relatively small changes in urine pH can cause a very marked change of salicylate concentrations in the plasma when relatively large doses of salicylate are used. We carried out a clinical study which confirmed this prediction. One gram of aspirin was given four times a day for seven days to 13 normal ambulatory adult volunteers, either with or without sufficient sodium bicarbonate ( about 4 gm/day) to increase urine pH somewhat (without http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Urine pH and Salicylate Therapy

Levy, Gerhard; Leonards, Jack R.
JAMA , Volume 217 (1) – Jul 5, 1971
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Urine pH and Salicylate Therapy

Abstract



To the Editor.—
The pronounced effect of urine pH on the renal clearance of salicylate is well known. Renal excretion is, however, only one of several pathways by which salicylate is eliminated from the body. The recently accomplished total characterization of the pharmacokinetics of salicylate elimination in man1,2 has made it possible to carry out computer simulations of the time course of salicylate levels in the body during long-term drug administration under different conditions....
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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1971 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1971.03190010063027
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— The pronounced effect of urine pH on the renal clearance of salicylate is well known. Renal excretion is, however, only one of several pathways by which salicylate is eliminated from the body. The recently accomplished total characterization of the pharmacokinetics of salicylate elimination in man1,2 has made it possible to carry out computer simulations of the time course of salicylate levels in the body during long-term drug administration under different conditions. These simulations predicted that relatively small changes in urine pH can cause a very marked change of salicylate concentrations in the plasma when relatively large doses of salicylate are used. We carried out a clinical study which confirmed this prediction. One gram of aspirin was given four times a day for seven days to 13 normal ambulatory adult volunteers, either with or without sufficient sodium bicarbonate ( about 4 gm/day) to increase urine pH somewhat (without

Journal

JAMA – American Medical Association

Published: Jul 5, 1971

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