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Urinary Tract Infections With Low and High Colony Counts in Young Women: Spontaneous Remission and Single-Dose vs Multiple-Day Treatment-Reply

Urinary Tract Infections With Low and High Colony Counts in Young Women: Spontaneous Remission... Abstract I thank Pfau for his interest in our article.1 Overall, my impression is that single-dose treatment of urinary tract infection is less effective than multiple-day treatment.2,3 Some agents are probably more effective than others when used as a single-dose treatment,3 and conceivably one of the quinolones given in a single dose may have efficacy comparable to that of multiple-day treatment. I am afraid that the study by Pfau et al4 does not offer convincing evidence in favor of the use of ofloxacin or ciprofloxacin as a single-dose treatment. The rates of cure, as given in the article and in the letter, are based on 11 patients who remained infected after treatment, but they do not include the nine patients with reinfection. Furthermore, the mean duration of follow-up was only 9.7 days. Stronger evidence has to be brought to convince us that an antibiotic drug can be References 1. Arav-Boger R, Leibovici L, Danon YL. Urinary tract infections with low and high colony counts in young women: spontaneous remission and single-dose vs multiple-day treatment . Arch Intern Med. 1994;154:300-304.Crossref 2. Philbrick JT, Bracikowski JP. Single-dose antibiotic treatment for uncomplicated urinary tract infection: less for less? Arch Intern Med. 1985;145:1672-1678.Crossref 3. Leibovici L, Wysenbeek AJ. Single-dose treatment for symptomatic urinary tract infections in women: a meta-analysis of randomized trials . QJ Med. 1991; 78:43-57. 4. Pfau A, Sacks TG. Single-dose quinolone treatment in acute uncomplicated urinary tract infection in women . J Urol. 1993;149:532-534. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Urinary Tract Infections With Low and High Colony Counts in Young Women: Spontaneous Remission and Single-Dose vs Multiple-Day Treatment-Reply

Archives of Internal Medicine , Volume 154 (21) – Nov 14, 1994

Urinary Tract Infections With Low and High Colony Counts in Young Women: Spontaneous Remission and Single-Dose vs Multiple-Day Treatment-Reply

Abstract

Abstract I thank Pfau for his interest in our article.1 Overall, my impression is that single-dose treatment of urinary tract infection is less effective than multiple-day treatment.2,3 Some agents are probably more effective than others when used as a single-dose treatment,3 and conceivably one of the quinolones given in a single dose may have efficacy comparable to that of multiple-day treatment. I am afraid that the study by Pfau et al4 does not offer convincing evidence in favor of the...
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Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1994.00420210141019
Publisher site
See Article on Publisher Site

Abstract

Abstract I thank Pfau for his interest in our article.1 Overall, my impression is that single-dose treatment of urinary tract infection is less effective than multiple-day treatment.2,3 Some agents are probably more effective than others when used as a single-dose treatment,3 and conceivably one of the quinolones given in a single dose may have efficacy comparable to that of multiple-day treatment. I am afraid that the study by Pfau et al4 does not offer convincing evidence in favor of the use of ofloxacin or ciprofloxacin as a single-dose treatment. The rates of cure, as given in the article and in the letter, are based on 11 patients who remained infected after treatment, but they do not include the nine patients with reinfection. Furthermore, the mean duration of follow-up was only 9.7 days. Stronger evidence has to be brought to convince us that an antibiotic drug can be References 1. Arav-Boger R, Leibovici L, Danon YL. Urinary tract infections with low and high colony counts in young women: spontaneous remission and single-dose vs multiple-day treatment . Arch Intern Med. 1994;154:300-304.Crossref 2. Philbrick JT, Bracikowski JP. Single-dose antibiotic treatment for uncomplicated urinary tract infection: less for less? Arch Intern Med. 1985;145:1672-1678.Crossref 3. Leibovici L, Wysenbeek AJ. Single-dose treatment for symptomatic urinary tract infections in women: a meta-analysis of randomized trials . QJ Med. 1991; 78:43-57. 4. Pfau A, Sacks TG. Single-dose quinolone treatment in acute uncomplicated urinary tract infection in women . J Urol. 1993;149:532-534.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 14, 1994

References