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UREMIA: III. THE NON-PROTEIN NITROGEN OF BLOOD

UREMIA: III. THE NON-PROTEIN NITROGEN OF BLOOD Abstract The nitrogen-containing crystalloids of blood have interested physiologists and clinicians for almost a century and in some respects the questions at issue are but little clearer to-day than in the time of Bright. Methods of research have changed and the data secured are more accurate, but it is remarkable in reviewing the literature that many of the conclusions of the later investigations are a simple rewording of the earlier. The facts have, however, been amplified and our knowledge made more complete without as yet any unaminity of opinion as to the significance of these facts. The amount of data at our disposal now is not inconsiderable and it may not be a useless task in the beginning to survey this field. Urea was first detected in the urine (matière savonneuse), by Rouelle, Jr., in 1773, and in 1821 Prevost and Dumas observed an accumulation of urea in the blood of References 1. Bright: Guys Hosp. Rep. , 1836, 1, 339. 2. Pickard : Thèse de Strassburg, 1856. 3. Schöndorff: Arch. f. d. ges. Physiol. (Pfluger's) , 1899, lxxiv, 307.Crossref 4. Rona and Michaelis: Biochem. Ztschr. , 1908, vii, 329 5. viii, 121. 6. Aszacki: Zentralbl. f. inn. Med. , 1912, xlvii, 1166. 7. Foster, Nellis B.: Pathological Deviations in the Chemistry of Uremic Blood , The Archives Int. Med. , (November) , 1912, p. 414. 8. Winterberg: Ztschr. f. klin. Med. , xxxv. 9. Folin: Jour. Biol. Chem. , 1914, xvii, 488. 10. Folin: Jour. Biol. Chem. , 1914, xvii, 489. 11. Myers and Fine: Proc. Soc. Exper. Biol. and Med. , 1914, xi, 132.Crossref 12. Due to the courtesy of Dr. Donald Van Slyke. 13. Folin, Karsner and Denis: Jour. Exper. Med. , 1912, xvi, 789.Crossref 14. Karsner and Denis: Jour. Exper. Med. , 1914, xix, 263. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

UREMIA: III. THE NON-PROTEIN NITROGEN OF BLOOD

Archives of Internal Medicine , Volume XV (3) – Mar 1, 1915

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Publisher
American Medical Association
Copyright
Copyright © 1915 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1915.00070210017002
Publisher site
See Article on Publisher Site

Abstract

Abstract The nitrogen-containing crystalloids of blood have interested physiologists and clinicians for almost a century and in some respects the questions at issue are but little clearer to-day than in the time of Bright. Methods of research have changed and the data secured are more accurate, but it is remarkable in reviewing the literature that many of the conclusions of the later investigations are a simple rewording of the earlier. The facts have, however, been amplified and our knowledge made more complete without as yet any unaminity of opinion as to the significance of these facts. The amount of data at our disposal now is not inconsiderable and it may not be a useless task in the beginning to survey this field. Urea was first detected in the urine (matière savonneuse), by Rouelle, Jr., in 1773, and in 1821 Prevost and Dumas observed an accumulation of urea in the blood of References 1. Bright: Guys Hosp. Rep. , 1836, 1, 339. 2. Pickard : Thèse de Strassburg, 1856. 3. Schöndorff: Arch. f. d. ges. Physiol. (Pfluger's) , 1899, lxxiv, 307.Crossref 4. Rona and Michaelis: Biochem. Ztschr. , 1908, vii, 329 5. viii, 121. 6. Aszacki: Zentralbl. f. inn. Med. , 1912, xlvii, 1166. 7. Foster, Nellis B.: Pathological Deviations in the Chemistry of Uremic Blood , The Archives Int. Med. , (November) , 1912, p. 414. 8. Winterberg: Ztschr. f. klin. Med. , xxxv. 9. Folin: Jour. Biol. Chem. , 1914, xvii, 488. 10. Folin: Jour. Biol. Chem. , 1914, xvii, 489. 11. Myers and Fine: Proc. Soc. Exper. Biol. and Med. , 1914, xi, 132.Crossref 12. Due to the courtesy of Dr. Donald Van Slyke. 13. Folin, Karsner and Denis: Jour. Exper. Med. , 1912, xvi, 789.Crossref 14. Karsner and Denis: Jour. Exper. Med. , 1914, xix, 263.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1915

References

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