Abstract • Reticulum cell sarcoma involving the vitreous and the brainstem occurred in a 45-year-old man. He initially was seen with diplopia from a partial left-sided third cranial nerve palsy, which is rare. Later, a typical uveitis developed in the right eye. An initial diagnosis of brainstem glioma, based primarily on the computed tomographic scan findings and clinical history, was ultimately proved erroneous when the correct diagnosis was shown by the results of a cytologic examination of a vitreous aspirate. Excellent visual response to a moderately high oral dose of steroids occurred, which has not been usual in other reported cases. Definitive cobalt (gamma) radiation therapy (6,000 rad to the brainstem and 4,000 rad to the vitreous) has produced a one-year remission at this time. References 1. Aisenberg AC: Malignant lymphoma (second of two parts) . N Engl J Med 1973;288:935-941.Crossref 2. Appen RE: Posterior uveitis and primary cerebral reticulum cell sarcoma . 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Klingele TG, Hogan MJ: Ocular reticulum cell sarcoma . Am J Ophthalmol 1975;79:39-47. 12. Lenhard, RE Jr, Ezdinli EZ, Costello W, et al: Treatment of histiocytic and mixed lymphomas: A comparison of 2, 3 and 4 drug chemotherapy . Cancer 1978;42:41-52.Crossref 13. Margolis L, Fraser R, Lichter A, et al: The role of radiation therapy in the management of ocular reticulum cell sarcoma . Cancer 1980;45:688-692.Crossref 14. Michels RG, Knox DL, Erozan Y, et al: Intraocular reticulum cell sarcoma: Diagnosis by pars plana vitrectomy . Arch Ophthalmol 1975;93:1331-1335.Crossref 15. Minckler DS, Font RL, Zimmerman LE: Uveitis and reticulum cell sarcoma of brain with bilateral neoplastic seeding of vitreous without retinal or uveal involvement . Am J Ophthalmol 1975;80:433-439. 16. Neault RW, VanScoy RE, Okazaki H, et al: Uveitis associated with isolated reticulum cell sarcoma of the brain . Am J Ophthalmol 1972;73:431-436. 17. 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Sullivan SF, Dallow RL: Intraocular reticulum cell sarcoma: Its dramatic response to systemic chemotherapy and its angiogenic potential . Ann Ophthalmol 1977;9:401-406. 24. Vogel MH, Font RL, Zimmerman LE, et al: Reticulum cell sarcoma of the retina and uvea: Report of six cases and review of the literature . Am J Ophthalmol 1968;66:205-215. 25. Hartshorne I: Lymphosarcoma of the orbit probably arising in the choroid . Am J Ophthalmol 1922;5:604-608. 26. McGavic JS: Lymphomatoid diseases involving the eye and its adnexa . Arch Ophthalmol 1943;30:179-193.Crossref 27. Beasley H: Lymphosarcoma of the choroid . Am J Ophthalmol 1961;51:1294-1296. 28. Schaumburg HH, Plank CR, Adams RD: The reticulum cell sarcoma-Microglia group of brain tumors: A consideration of their clinical features and therapy . Brain 1972;95:199-212.Crossref 29. Adams JH, Jackson JM: Intracerebral tumors of reticular tissue: The problem of microgliomatosis and reticulo-endothelial sarcoma of the brain . 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Archives of Ophthalmology – American Medical Association
Published: Jun 1, 1981
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