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Unique Mice May Help Reveal Human Response to Chemical Exposure

Unique Mice May Help Reveal Human Response to Chemical Exposure News & Analysis Health Agencies Update New Effort Hopes to Boost Mental doi:10.1289/ehp.1408202 [published on- Health Research line November 6, 2014]). Traditionally, iso- A new unit established by the National In- genic mice are used to assess the effects of stitute of Mental Health hopes to facilitate exposure; however, because of lack of ge- communication among scientists, clini- netic diversity, these models may not accu- cians, and the public to reframe mental rately predict the range of sensitivities to health research. chemicals in humans. The Research Domain Criteria (RDoC) For their experiments, scientists unit is currently developing an online discus- exposed Diversity Outbred mice to ben- sion forum where investigators and clini- zene, a common air pollutant, at 0, 1, 10, or cians can converse and collaborate. 100 ppm via inhalation for 26 to 28 days Following controversies concerning shortcomings The unit is the latest program within (with 6 hours of exposure each day for 5 in responsiveness, transparency, and accountability, the RDoC initiative, which was established d/wk). The mice were derived from 8 the Department of Veterans Affairs is planning changes to reorganize and improve care. in 2009 to accelerate the pace of research inbred founder strains that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Unique Mice May Help Reveal Human Response to Chemical Exposure

Hampton, Tracy
JAMA , Volume 312 (24) – Dec 24, 2014
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Unique Mice May Help Reveal Human Response to Chemical Exposure

Abstract

News & Analysis Health Agencies Update New Effort Hopes to Boost Mental doi:10.1289/ehp.1408202 [published on- Health Research line November 6, 2014]). Traditionally, iso- A new unit established by the National In- genic mice are used to assess the effects of stitute of Mental Health hopes to facilitate exposure; however, because of lack of ge- communication among scientists, clini- netic diversity, these models may not accu- cians, and the public to reframe mental rately predict the...
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Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2014.17033
Publisher site
See Article on Publisher Site

Abstract

News & Analysis Health Agencies Update New Effort Hopes to Boost Mental doi:10.1289/ehp.1408202 [published on- Health Research line November 6, 2014]). Traditionally, iso- A new unit established by the National In- genic mice are used to assess the effects of stitute of Mental Health hopes to facilitate exposure; however, because of lack of ge- communication among scientists, clini- netic diversity, these models may not accu- cians, and the public to reframe mental rately predict the range of sensitivities to health research. chemicals in humans. The Research Domain Criteria (RDoC) For their experiments, scientists unit is currently developing an online discus- exposed Diversity Outbred mice to ben- sion forum where investigators and clini- zene, a common air pollutant, at 0, 1, 10, or cians can converse and collaborate. 100 ppm via inhalation for 26 to 28 days Following controversies concerning shortcomings The unit is the latest program within (with 6 hours of exposure each day for 5 in responsiveness, transparency, and accountability, the RDoC initiative, which was established d/wk). The mice were derived from 8 the Department of Veterans Affairs is planning changes to reorganize and improve care. in 2009 to accelerate the pace of research inbred founder strains that

Journal

JAMA – American Medical Association

Published: Dec 24, 2014

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